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Atomistry » Zinc » PDB 4jse-4k4e » 4jt9 » |
Zinc in PDB 4jt9: Crystal Structure of Human SIRT3 with Elt Inhibitor 3 [14-(4-{2- [(Methylsulfonyl)Amino]Ethyl}Piperidin-1-Yl)Thieno[3,2-D]Pyrimidine- 6-Carboxamide]Protein crystallography data
The structure of Crystal Structure of Human SIRT3 with Elt Inhibitor 3 [14-(4-{2- [(Methylsulfonyl)Amino]Ethyl}Piperidin-1-Yl)Thieno[3,2-D]Pyrimidine- 6-Carboxamide], PDB code: 4jt9
was solved by
H.Dai,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4jt9:
The structure of Crystal Structure of Human SIRT3 with Elt Inhibitor 3 [14-(4-{2- [(Methylsulfonyl)Amino]Ethyl}Piperidin-1-Yl)Thieno[3,2-D]Pyrimidine- 6-Carboxamide] also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of Human SIRT3 with Elt Inhibitor 3 [14-(4-{2- [(Methylsulfonyl)Amino]Ethyl}Piperidin-1-Yl)Thieno[3,2-D]Pyrimidine- 6-Carboxamide]
(pdb code 4jt9). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Human SIRT3 with Elt Inhibitor 3 [14-(4-{2- [(Methylsulfonyl)Amino]Ethyl}Piperidin-1-Yl)Thieno[3,2-D]Pyrimidine- 6-Carboxamide], PDB code: 4jt9: Zinc binding site 1 out of 1 in 4jt9Go back to Zinc Binding Sites List in 4jt9
Zinc binding site 1 out
of 1 in the Crystal Structure of Human SIRT3 with Elt Inhibitor 3 [14-(4-{2- [(Methylsulfonyl)Amino]Ethyl}Piperidin-1-Yl)Thieno[3,2-D]Pyrimidine- 6-Carboxamide]
Mono view Stereo pair view
Reference:
J.S.Disch,
G.Evindar,
C.H.Chiu,
C.A.Blum,
H.Dai,
L.Jin,
E.Schuman,
K.E.Lind,
S.L.Belyanskaya,
J.Deng,
F.Coppo,
L.Aquilani,
T.L.Graybill,
J.W.Cuozzo,
S.Lavu,
C.Mao,
G.P.Vlasuk,
R.B.Perni.
Discovery of Thieno[3,2-D]Pyrimidine-6-Carboxamides As Potent Inhibitors of SIRT1, SIRT2, and SIRT3. J.Med.Chem. V. 56 3666 2013.
Page generated: Wed Dec 16 05:27:06 2020
ISSN: ISSN 0022-2623 PubMed: 23570514 DOI: 10.1021/JM400204K |
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