Zinc in PDB 4iof: Crystal Structure Analysis of Fab-Bound Human Insulin Degrading Enzyme (Ide)

All present enzymatic activity of Crystal Structure Analysis of Fab-Bound Human Insulin Degrading Enzyme (Ide):
3.4.24.56;

The structure of Crystal Structure Analysis of Fab-Bound Human Insulin Degrading Enzyme (Ide), PDB code: 4iof was solved by L.A.Mccord, W.G.Liang, R.Hoey, E.Dowdell, A.Koide, S.Koide, W.J.Tang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	49.85 / 3.35
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	56.955, 131.662, 377.039, 90.00, 90.00, 90.00
R / Rfree (%)	23.2 / 28

The binding sites of Zinc atom in the Crystal Structure Analysis of Fab-Bound Human Insulin Degrading Enzyme (Ide) (pdb code 4iof). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure Analysis of Fab-Bound Human Insulin Degrading Enzyme (Ide), PDB code: 4iof:

Zinc binding site 1 out of 1 in the Crystal Structure Analysis of Fab-Bound Human Insulin Degrading Enzyme (Ide)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure Analysis of Fab-Bound Human Insulin Degrading Enzyme (Ide) within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1101 b:75.4 occ:1.00 OE1 A:GLU189 2.0 89.2 1.0 NE2 A:HIS112 2.0 83.8 1.0 NE2 A:HIS108 2.0 42.0 1.0 CE1 A:HIS112 2.6 83.7 1.0 CE1 A:HIS108 2.9 42.1 1.0 CD A:GLU189 2.9 89.1 1.0 CD2 A:HIS108 3.0 42.2 1.0 CD2 A:HIS112 3.2 84.0 1.0 OE2 A:GLU189 3.2 89.1 1.0 ND1 A:HIS112 3.9 83.9 1.0 ND1 A:HIS108 4.0 42.4 1.0 CG A:HIS108 4.1 42.5 1.0 CG A:HIS112 4.1 84.0 1.0 OE2 A:GLU111 4.2 48.3 1.0 CG A:GLU189 4.3 89.0 1.0 CB A:GLU189 4.8 89.1 1.0 OE1 A:GLU111 4.9 48.2 1.0 CG2 A:VAL186 4.9 50.4 1.0 CD A:GLU111 4.9 48.3 1.0

L.A.Mccord, W.G.Liang, E.Dowdell, V.Kalas, R.J.Hoey, A.Koide, S.Koide, W.J.Tang. Conformational States and Recognition of Amyloidogenic Peptides of Human Insulin-Degrading Enzyme. Proc.Natl.Acad.Sci.Usa V. 110 13827 2013.
ISSN: ISSN 0027-8424
PubMed: 23922390
DOI: 10.1073/PNAS.1304575110