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Zinc in PDB 4iav: G215S, A251G, T257A, D260G, T262D Mutant of Carboxypeptidase T From Thermoactinomyces Vulgaris with N-Sulfamoyl-L-Phenylalanine

Enzymatic activity of G215S, A251G, T257A, D260G, T262D Mutant of Carboxypeptidase T From Thermoactinomyces Vulgaris with N-Sulfamoyl-L-Phenylalanine

All present enzymatic activity of G215S, A251G, T257A, D260G, T262D Mutant of Carboxypeptidase T From Thermoactinomyces Vulgaris with N-Sulfamoyl-L-Phenylalanine:
3.4.17.18;

Protein crystallography data

The structure of G215S, A251G, T257A, D260G, T262D Mutant of Carboxypeptidase T From Thermoactinomyces Vulgaris with N-Sulfamoyl-L-Phenylalanine, PDB code: 4iav was solved by V.I.Timofeev, S.A.Kuznetsov, V.K.Akparov, I.P.Kuranova, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 10.00 / 1.35
Space group P 63 2 2
Cell size a, b, c (Å), α, β, γ (°) 157.722, 157.722, 104.461, 90.00, 90.00, 120.00
R / Rfree (%) 13.9 / 15.4

Other elements in 4iav:

The structure of G215S, A251G, T257A, D260G, T262D Mutant of Carboxypeptidase T From Thermoactinomyces Vulgaris with N-Sulfamoyl-L-Phenylalanine also contains other interesting chemical elements:

Calcium (Ca) 5 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the G215S, A251G, T257A, D260G, T262D Mutant of Carboxypeptidase T From Thermoactinomyces Vulgaris with N-Sulfamoyl-L-Phenylalanine (pdb code 4iav). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the G215S, A251G, T257A, D260G, T262D Mutant of Carboxypeptidase T From Thermoactinomyces Vulgaris with N-Sulfamoyl-L-Phenylalanine, PDB code: 4iav:

Zinc binding site 1 out of 1 in 4iav

Go back to Zinc Binding Sites List in 4iav
Zinc binding site 1 out of 1 in the G215S, A251G, T257A, D260G, T262D Mutant of Carboxypeptidase T From Thermoactinomyces Vulgaris with N-Sulfamoyl-L-Phenylalanine


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of G215S, A251G, T257A, D260G, T262D Mutant of Carboxypeptidase T From Thermoactinomyces Vulgaris with N-Sulfamoyl-L-Phenylalanine within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn401

b:8.6
occ:1.00
 N19 A:CXA402 2.1 10.8 1.0
ND1 A:HIS69 2.1 8.2 1.0
OE1 A:GLU72 2.1 9.0 1.0
ND1 A:HIS204 2.1 8.1 1.0
OE2 A:GLU72 2.4 9.9 1.0
CD A:GLU72 2.6 9.5 1.0
CE1 A:HIS69 3.0 7.9 1.0
CE1 A:HIS204 3.1 8.2 1.0
CG A:HIS204 3.1 7.3 1.0
CG A:HIS69 3.2 8.0 1.0
S18 A:CXA402 3.2 14.4 1.0
O21 A:CXA402 3.3 15.2 1.0
CB A:HIS204 3.4 7.2 1.0
CB A:HIS69 3.6 8.4 1.0
O A:THR205 3.9 8.0 1.0
O A:HOH512 3.9 11.8 1.0
CG A:GLU72 4.1 9.0 1.0
N17 A:CXA402 4.1 14.6 1.0
NE2 A:HIS69 4.1 8.1 1.0
C13 A:CXA402 4.1 13.0 1.0
NE2 A:HIS204 4.2 8.5 1.0
CD2 A:HIS69 4.2 8.1 1.0
CD2 A:HIS204 4.2 7.6 1.0
CA A:HIS204 4.3 7.3 1.0
O A:HOH541 4.3 18.6 0.9
O20 A:CXA402 4.4 16.9 1.0
N A:THR205 4.5 7.7 1.0
NH1 A:ARG129 4.6 11.7 1.0
C14 A:CXA402 4.7 11.0 1.0
OE1 A:GLU277 4.7 12.8 1.0
O15 A:CXA402 4.8 11.5 1.0
CA A:HIS69 4.8 7.9 1.0
N A:HIS69 4.8 8.7 1.0
C A:HIS204 4.9 7.5 1.0
CB A:GLU72 4.9 8.1 1.0
C A:THR205 5.0 7.9 1.0

Reference:

V.I.Timofeev, S.A.Kuznetsov, V.K.Akparov, I.P.Kuranova. G215S, A251G, T257A, D260G, T262D Mutant of Carboxypeptidase T From Thermoactinomyces Vulgaris with N-Sulfamoyl-L-Phenylalanine To Be Published.
Page generated: Sun Oct 27 00:35:07 2024

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