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Zinc in PDB 4i14: Crystal Structure of Mtb-RIBA2 (RV1415)

Enzymatic activity of Crystal Structure of Mtb-RIBA2 (RV1415)

All present enzymatic activity of Crystal Structure of Mtb-RIBA2 (RV1415):
3.5.4.25; 4.1.99.12;

Protein crystallography data

The structure of Crystal Structure of Mtb-RIBA2 (RV1415), PDB code: 4i14 was solved by M.Singh, P.Kumar, S.Yadav, R.Gautam, N.Sharma, S.Karthikeyan, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 19.73 / 3.00
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 168.764, 74.839, 76.427, 90.00, 90.00, 90.00
R / Rfree (%) 19.7 / 26.3

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Mtb-RIBA2 (RV1415) (pdb code 4i14). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Mtb-RIBA2 (RV1415), PDB code: 4i14:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 4i14

Go back to Zinc Binding Sites List in 4i14
Zinc binding site 1 out of 2 in the Crystal Structure of Mtb-RIBA2 (RV1415)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Mtb-RIBA2 (RV1415) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn501

b:56.5
occ:0.70
SG A:CYS277 2.3 75.4 1.0
SG A:CYS264 2.5 69.5 1.0
SG A:CYS275 2.6 79.9 1.0
O A:HOH601 2.9 36.2 1.0
CB A:CYS275 3.0 86.2 1.0
CB A:CYS277 3.0 73.6 1.0
CB A:CYS264 3.6 65.7 1.0
N A:CYS277 4.2 79.3 1.0
CA A:CYS277 4.2 75.1 1.0
CA A:CYS275 4.4 89.4 1.0
CA A:GLY267 4.7 69.9 1.0
C A:CYS275 4.7 86.8 1.0
OG1 A:THR266 4.8 76.3 1.0
N A:GLY267 4.8 69.8 1.0
CA A:CYS264 5.0 63.5 1.0
N A:ASP276 5.0 87.6 1.0

Zinc binding site 2 out of 2 in 4i14

Go back to Zinc Binding Sites List in 4i14
Zinc binding site 2 out of 2 in the Crystal Structure of Mtb-RIBA2 (RV1415)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Mtb-RIBA2 (RV1415) within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn501

b:54.2
occ:0.75
SG B:CYS275 1.9 63.8 1.0
SG B:CYS277 2.3 62.1 1.0
SG B:CYS264 2.4 55.0 1.0
O B:HOH601 2.7 18.6 1.0
CB B:CYS277 3.2 61.8 1.0
CB B:CYS264 3.3 53.4 1.0
CB B:CYS275 3.6 66.8 1.0
O B:CYS275 4.3 71.0 1.0
N B:CYS277 4.4 66.6 1.0
CA B:CYS277 4.4 64.4 1.0
CA B:CYS275 4.4 69.8 1.0
C B:CYS275 4.5 70.3 1.0
CA B:CYS264 4.7 52.1 1.0
CA B:GLY267 5.0 56.5 1.0

Reference:

M.Singh, P.Kumar, S.Yadav, R.Gautam, N.Sharma, S.Karthikeyan. The Crystal Structure Reveals the Molecular Mechanism of Bifunctional 3,4-Dihydroxy-2-Butanone 4-Phosphate Synthase/Gtp Cyclohydrolase II (RV1415) From Mycobacterium Tuberculosis Acta Crystallogr.,Sect.D V. 69 1633 2013.
ISSN: ISSN 0907-4449
PubMed: 23999287
DOI: 10.1107/S0907444913011402
Page generated: Sun Oct 27 00:25:48 2024

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