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Zinc in PDB 4ht2: Crystal Structure of Human Carbonic Anhydrase Isozyme XII with the Inhibitor.
Enzymatic activity of Crystal Structure of Human Carbonic Anhydrase Isozyme XII with the Inhibitor.
All present enzymatic activity of Crystal Structure of Human Carbonic Anhydrase Isozyme XII with the Inhibitor.:
4.2.1.1;
4.2.1.1;
Protein crystallography data
The structure of Crystal Structure of Human Carbonic Anhydrase Isozyme XII with the Inhibitor., PDB code: 4ht2
was solved by
A.Smirnov,
E.Manakova,
S.Grazulis,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 26.50 / 1.45 |
| Space group | P 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 46.709, 67.261, 80.689, 81.78, 84.01, 86.48 |
| R / Rfree (%) | 15 / 18.8 |
Other elements in 4ht2:
The structure of Crystal Structure of Human Carbonic Anhydrase Isozyme XII with the Inhibitor. also contains other interesting chemical elements:
| Fluorine | (F) | 20 atoms |
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of Human Carbonic Anhydrase Isozyme XII with the Inhibitor.
(pdb code 4ht2). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Crystal Structure of Human Carbonic Anhydrase Isozyme XII with the Inhibitor., PDB code: 4ht2:
Jump to Zinc binding site number: 1; 2; 3; 4;
In total 4 binding sites of Zinc where determined in the Crystal Structure of Human Carbonic Anhydrase Isozyme XII with the Inhibitor., PDB code: 4ht2:
Jump to Zinc binding site number: 1; 2; 3; 4;
Zinc binding site 1 out of 4 in 4ht2
Go back to
Zinc Binding Sites List in 4ht2
Zinc binding site 1 out
of 4 in the Crystal Structure of Human Carbonic Anhydrase Isozyme XII with the Inhibitor.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of Crystal Structure of Human Carbonic Anhydrase Isozyme XII with the Inhibitor. within 5.0Å range:
|
Zinc binding site 2 out of 4 in 4ht2
Go back to
Zinc Binding Sites List in 4ht2
Zinc binding site 2 out
of 4 in the Crystal Structure of Human Carbonic Anhydrase Isozyme XII with the Inhibitor.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 2 of Crystal Structure of Human Carbonic Anhydrase Isozyme XII with the Inhibitor. within 5.0Å range:
|
Zinc binding site 3 out of 4 in 4ht2
Go back to
Zinc Binding Sites List in 4ht2
Zinc binding site 3 out
of 4 in the Crystal Structure of Human Carbonic Anhydrase Isozyme XII with the Inhibitor.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 3 of Crystal Structure of Human Carbonic Anhydrase Isozyme XII with the Inhibitor. within 5.0Å range:
|
Zinc binding site 4 out of 4 in 4ht2
Go back to
Zinc Binding Sites List in 4ht2
Zinc binding site 4 out
of 4 in the Crystal Structure of Human Carbonic Anhydrase Isozyme XII with the Inhibitor.
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 4 of Crystal Structure of Human Carbonic Anhydrase Isozyme XII with the Inhibitor. within 5.0Å range:
|
Reference:
V.Dudutiene,
A.Zubriene,
A.Smirnov,
J.Gylyte,
D.Timm,
E.Manakova,
S.Grazulis,
D.Matulis.
4-Substituted-2,3,5,6-Tetrafluorobenzenesulfonamides As Inhibitors of Carbonic Anhydrases I, II, VII, XII, and XIII. Bioorg.Med.Chem. V. 21 2093 2013.
ISSN: ISSN 0968-0896
PubMed: 23394791
DOI: 10.1016/J.BMC.2013.01.008
Page generated: Wed Dec 16 05:22:44 2020
ISSN: ISSN 0968-0896
PubMed: 23394791
DOI: 10.1016/J.BMC.2013.01.008
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