Zinc in PDB 4hn5: Gr Dna Binding Domain - Tslp Ngre Complex

The structure of Gr Dna Binding Domain - Tslp Ngre Complex, PDB code: 4hn5 was solved by W.H.Hudson, C.E.Youn, E.A.Ortlund, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	26.01 / 1.90
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	39.349, 96.568, 103.995, 90.00, 90.00, 90.00
R / Rfree (%)	20.7 / 23.5

The binding sites of Zinc atom in the Gr Dna Binding Domain - Tslp Ngre Complex (pdb code 4hn5). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Gr Dna Binding Domain - Tslp Ngre Complex, PDB code: 4hn5:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Gr Dna Binding Domain - Tslp Ngre Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Gr Dna Binding Domain - Tslp Ngre Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn601 b:30.4 occ:1.00 SG A:CYS424 2.2 33.3 1.0 SG A:CYS421 2.3 29.4 1.0 SG A:CYS441 2.4 29.4 1.0 SG A:CYS438 2.4 32.5 1.0 CB A:CYS441 3.2 32.8 1.0 CB A:CYS421 3.2 31.2 1.0 CB A:CYS424 3.4 31.1 1.0 CB A:CYS438 3.6 35.1 1.0 N A:CYS424 3.7 29.4 1.0 N A:CYS438 3.9 32.0 1.0 CA A:CYS424 4.1 32.0 1.0 N A:CYS441 4.2 33.7 1.0 CA A:CYS441 4.3 32.0 1.0 CA A:CYS438 4.3 37.3 1.0 NH1 A:ARG470 4.3 33.8 1.0 CB A:VAL423 4.5 27.0 1.0 CB A:ASP426 4.6 38.2 1.0 C A:CYS424 4.7 32.4 1.0 CA A:CYS421 4.7 32.4 1.0 C A:VAL423 4.7 33.0 1.0 N A:ASP426 4.8 35.9 1.0 N A:SER425 4.9 34.1 1.0 O A:CYS438 4.9 35.5 1.0 NH2 A:ARG477 4.9 30.7 1.0 C A:CYS438 4.9 39.2 1.0 CA A:VAL423 5.0 26.8 1.0 N A:VAL423 5.0 27.2 1.0

Zinc binding site 2 out of 4 in the Gr Dna Binding Domain - Tslp Ngre Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Gr Dna Binding Domain - Tslp Ngre Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn602 b:25.7 occ:1.00 SG A:CYS473 2.3 26.9 1.0 SG A:CYS463 2.3 27.1 1.0 SG A:CYS476 2.3 25.3 1.0 SG A:CYS457 2.3 26.7 1.0 CB A:CYS463 3.2 26.8 1.0 CB A:CYS457 3.3 30.1 1.0 CB A:CYS476 3.3 22.4 1.0 CB A:CYS473 3.3 26.4 1.0 O A:HOH703 3.8 27.9 1.0 N A:CYS463 3.9 26.1 1.0 CA A:CYS457 4.0 29.2 1.0 CA A:CYS463 4.2 26.0 1.0 N A:CYS476 4.2 23.9 1.0 CA A:CYS476 4.3 24.1 1.0 CA A:ASN461 4.4 32.1 1.0 O A:HOH706 4.5 28.9 1.0 N A:ASN461 4.6 28.8 1.0 O A:HOH723 4.6 30.1 1.0 N A:ALA458 4.6 26.4 1.0 N A:ASP462 4.6 28.4 1.0 C A:CYS457 4.7 31.4 1.0 N A:GLY459 4.8 26.6 1.0 CA A:CYS473 4.8 25.6 1.0 C A:ASN461 4.8 30.8 1.0 O A:HOH707 4.9 29.7 1.0

Zinc binding site 3 out of 4 in the Gr Dna Binding Domain - Tslp Ngre Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Gr Dna Binding Domain - Tslp Ngre Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn601 b:26.7 occ:1.00 SG B:CYS473 2.3 25.7 1.0 SG B:CYS457 2.3 25.9 1.0 SG B:CYS463 2.3 26.4 1.0 SG B:CYS476 2.3 26.7 1.0 CB B:CYS463 3.3 28.3 1.0 CB B:CYS457 3.3 27.5 1.0 CB B:CYS476 3.4 28.9 1.0 CB B:CYS473 3.4 25.4 1.0 N B:CYS463 3.9 27.9 1.0 CA B:CYS457 4.0 25.6 1.0 O B:HOH714 4.1 30.0 1.0 CA B:CYS463 4.2 28.6 1.0 N B:CYS476 4.2 28.5 1.0 CA B:CYS476 4.4 28.2 1.0 CA B:ASN461 4.5 24.8 1.0 N B:ASP462 4.5 27.1 1.0 N B:ASN461 4.6 25.9 1.0 N B:ALA458 4.7 24.1 1.0 C B:CYS457 4.7 27.4 1.0 CA B:CYS473 4.8 29.1 1.0 C B:ASN461 4.8 29.5 1.0 N B:GLY459 4.8 25.0 1.0 O B:HOH701 4.9 33.7 1.0

Zinc binding site 4 out of 4 in the Gr Dna Binding Domain - Tslp Ngre Complex


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Gr Dna Binding Domain - Tslp Ngre Complex within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn602 b:37.5 occ:1.00 SG B:CYS441 2.3 35.5 1.0 SG B:CYS438 2.3 40.5 1.0 SG B:CYS424 2.4 38.7 1.0 SG B:CYS421 2.4 39.0 1.0 CB B:CYS441 3.2 36.8 1.0 CB B:CYS421 3.3 41.2 1.0 CB B:CYS424 3.3 40.7 1.0 CB B:CYS438 3.6 43.5 1.0 N B:CYS424 3.8 40.1 1.0 N B:CYS438 3.9 41.0 1.0 CA B:CYS424 4.1 37.6 1.0 N B:CYS441 4.2 36.3 1.0 CA B:CYS441 4.3 36.5 1.0 CA B:CYS438 4.3 39.9 1.0 NH1 B:ARG470 4.4 38.8 1.0 OG B:SER440 4.5 40.5 1.0 CB B:VAL423 4.5 39.0 1.0 C B:CYS424 4.6 41.4 1.0 CB B:ASP426 4.7 43.3 1.0 CA B:CYS421 4.7 43.9 1.0 C B:VAL423 4.8 40.8 1.0 N B:SER425 4.8 42.4 1.0 O B:CYS438 4.8 39.4 1.0 C B:CYS438 4.9 38.3 1.0 N B:ASP426 4.9 40.0 1.0 NH2 B:ARG477 4.9 35.1 1.0

W.H.Hudson, C.Youn, E.A.Ortlund. The Structural Basis of Direct Glucocorticoid-Mediated Transrepression. Nat.Struct.Mol.Biol. V. 20 53 2013.
ISSN: ISSN 1545-9993
PubMed: 23222642
DOI: 10.1038/NSMB.2456