Zinc in PDB 4gv9: Lassa Nucleoprotein C-Terminal Domain in Complex with Triphosphated Dsrna Soaking For 5 Min

The structure of Lassa Nucleoprotein C-Terminal Domain in Complex with Triphosphated Dsrna Soaking For 5 Min, PDB code: 4gv9 was solved by X.Jiang, Q.Huang, W.Wang, H.Dong, H.Ly, Y.Liang, C.Dong, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	43.89 / 2.46
Space group	P 41 21 2
Cell size a, b, c (Å), α, β, γ (°)	44.780, 44.780, 221.740, 90.00, 90.00, 90.00
R / Rfree (%)	25.9 / 30.5

The structure of Lassa Nucleoprotein C-Terminal Domain in Complex with Triphosphated Dsrna Soaking For 5 Min also contains other interesting chemical elements:

Manganese

(Mn)

3 atoms

The binding sites of Zinc atom in the Lassa Nucleoprotein C-Terminal Domain in Complex with Triphosphated Dsrna Soaking For 5 Min (pdb code 4gv9). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Lassa Nucleoprotein C-Terminal Domain in Complex with Triphosphated Dsrna Soaking For 5 Min, PDB code: 4gv9:

Zinc binding site 1 out of 1 in the Lassa Nucleoprotein C-Terminal Domain in Complex with Triphosphated Dsrna Soaking For 5 Min


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Lassa Nucleoprotein C-Terminal Domain in Complex with Triphosphated Dsrna Soaking For 5 Min within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn601 b:57.1 occ:1.00 OE2 A:GLU399 2.1 52.7 1.0 SG A:CYS529 2.1 51.5 1.0 SG A:CYS506 2.2 54.1 1.0 NE2 A:HIS509 2.2 58.7 1.0 CD2 A:HIS509 3.0 59.9 1.0 CD A:GLU399 3.0 52.4 1.0 CB A:CYS506 3.3 54.7 1.0 CB A:CYS529 3.3 52.3 1.0 OE1 A:GLU399 3.3 54.3 1.0 CE1 A:HIS509 3.3 59.1 1.0 NE2 A:HIS412 3.7 42.5 1.0 CA A:CYS529 3.9 52.0 1.0 CE1 A:HIS412 4.0 42.6 1.0 CG A:HIS509 4.2 60.9 1.0 ND1 A:HIS509 4.3 60.4 1.0 CG A:GLU399 4.4 49.6 1.0 N A:ALA530 4.4 49.5 1.0 CE2 A:PHE414 4.5 44.7 1.0 C A:CYS529 4.6 50.9 1.0 CZ A:PHE414 4.6 43.9 1.0 CA A:CYS506 4.7 55.9 1.0 CD2 A:HIS412 4.9 41.6 1.0 N A:LEU531 5.0 47.0 1.0

X.Jiang, Q.Huang, W.Wang, H.Dong, H.Ly, Y.Liang, C.Dong. Structures of Arenaviral Nucleoproteins with Triphosphate Dsrna Reveal A Unique Mechanism of Immune Suppression. J.Biol.Chem. V. 288 16949 2013.
ISSN: ISSN 0021-9258
PubMed: 23615902
DOI: 10.1074/JBC.M112.420521