|
Zinc in PDB 4g2j: Human PDE9 in Complex with Selective CompoundEnzymatic activity of Human PDE9 in Complex with Selective Compound
All present enzymatic activity of Human PDE9 in Complex with Selective Compound:
3.1.4.35; Protein crystallography data
The structure of Human PDE9 in Complex with Selective Compound, PDB code: 4g2j
was solved by
S.Liu,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4g2j:
The structure of Human PDE9 in Complex with Selective Compound also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Human PDE9 in Complex with Selective Compound
(pdb code 4g2j). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Human PDE9 in Complex with Selective Compound, PDB code: 4g2j: Jump to Zinc binding site number: 1; 2; Zinc binding site 1 out of 2 in 4g2jGo back to Zinc Binding Sites List in 4g2j
Zinc binding site 1 out
of 2 in the Human PDE9 in Complex with Selective Compound
Mono view Stereo pair view
Zinc binding site 2 out of 2 in 4g2jGo back to Zinc Binding Sites List in 4g2j
Zinc binding site 2 out
of 2 in the Human PDE9 in Complex with Selective Compound
Mono view Stereo pair view
Reference:
M.M.Claffey,
C.J.Helal,
P.R.Verhoest,
Z.Kang,
K.S.Fors,
S.Jung,
J.Zhong,
M.W.Bundesmann,
X.Hou,
S.Lui,
R.J.Kleiman,
M.Vanase-Frawley,
A.W.Schmidt,
F.Menniti,
C.J.Schmidt,
W.E.Hoffman,
M.Hajos,
L.Mcdowell,
R.E.O'connor,
M.Macdougall-Murphy,
K.R.Fonseca,
S.L.Becker,
F.R.Nelson,
S.Liras.
Application of Structure-Based Drug Design and Parallel Chemistry to Identify Selective, Brain Penetrant, in Vivo Active Phosphodiesterase 9A Inhibitors. J.Med.Chem. V. 55 9055 2012.
Page generated: Wed Dec 16 05:18:57 2020
ISSN: ISSN 0022-2623 PubMed: 23025719 DOI: 10.1021/JM3009635 |
Last articlesZn in 8WB0Zn in 8WAX Zn in 8WAU Zn in 8WAZ Zn in 8WAY Zn in 8WAV Zn in 8WAW Zn in 8WAT Zn in 8W7M Zn in 8WD3 |
© Copyright 2008-2020 by atomistry.com | ||
Home | Site Map | Copyright | Contact us | Privacy |