Zinc in PDB 4g0c: Neutron Structure of Acetazolamide-Bound Human Carbonic Anhydrase II Reveal Molecular Details of Drug Binding.

All present enzymatic activity of Neutron Structure of Acetazolamide-Bound Human Carbonic Anhydrase II Reveal Molecular Details of Drug Binding.:
4.2.1.1;

The binding sites of Zinc atom in the Neutron Structure of Acetazolamide-Bound Human Carbonic Anhydrase II Reveal Molecular Details of Drug Binding. (pdb code 4g0c). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Neutron Structure of Acetazolamide-Bound Human Carbonic Anhydrase II Reveal Molecular Details of Drug Binding., PDB code: 4g0c:

Zinc binding site 1 out of 1 in the Neutron Structure of Acetazolamide-Bound Human Carbonic Anhydrase II Reveal Molecular Details of Drug Binding.


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Neutron Structure of Acetazolamide-Bound Human Carbonic Anhydrase II Reveal Molecular Details of Drug Binding. within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn301 b:9.4 occ:1.00 ND1 A:HIS119 2.1 9.3 1.0 NE2 A:HIS96 2.2 8.4 1.0 NE2 A:HIS94 2.2 11.6 1.0 N1 A:AZM302 2.4 11.4 1.0 HD2 A:HIS94 2.9 9.9 1.0 O2 A:AZM302 2.9 12.7 1.0 CD2 A:HIS94 2.9 12.0 1.0 CE1 A:HIS119 2.9 7.5 1.0 HE1 A:HIS119 3.0 8.7 1.0 CD2 A:HIS96 3.0 10.4 1.0 DN11 A:AZM302 3.1 11.3 1.0 HB2 A:HIS119 3.1 10.3 1.0 S1 A:AZM302 3.1 11.1 1.0 CE1 A:HIS96 3.2 9.3 1.0 HD2 A:HIS96 3.2 8.9 1.0 CG A:HIS119 3.3 9.6 1.0 CE1 A:HIS94 3.3 10.2 1.0 HE1 A:HIS96 3.4 8.3 1.0 D2 A:DOD1143 3.5 20.5 1.0 HE1 A:HIS94 3.6 12.4 1.0 CB A:HIS119 3.7 9.4 1.0 DG1 A:THR199 3.7 9.4 0.9 HB3 A:HIS119 3.9 10.1 1.0 O A:DOD1143 4.0 59.8 0.5 OG1 A:THR199 4.0 9.7 1.0 OE1 A:GLU106 4.1 10.2 1.0 HH2 A:TRP209 4.1 12.2 1.0 NE2 A:HIS119 4.1 8.2 1.0 CG A:HIS94 4.1 10.1 1.0 O1 A:AZM302 4.2 11.1 1.0 CG A:HIS96 4.2 9.9 1.0 ND1 A:HIS96 4.3 10.3 1.0 ND1 A:HIS94 4.3 9.4 1.0 CD2 A:HIS119 4.3 9.3 1.0 O A:DOD1144 4.3 59.7 0.5 C1 A:AZM302 4.3 13.2 1.0 D1 A:DOD1143 4.4 20.5 1.0 D1 A:DOD1144 4.8 20.5 1.0 HG13 A:VAL143 4.8 10.6 1.0 HG22 A:THR200 4.8 12.5 1.0 DE2 A:HIS119 4.9 8.7 0.5 CD A:GLU106 5.0 10.2 1.0

S.Z.Fisher, M.Aggarwal, A.Y.Kovalevsky, D.N.Silverman, R.Mckenna. Neutron Diffraction of Acetazolamide-Bound Human Carbonic Anhydrase II Reveals Atomic Details of Drug Binding. J.Am.Chem.Soc. V. 134 14726 2012.
ISSN: ISSN 0002-7863
PubMed: 22928733
DOI: 10.1021/JA3068098