Zinc in PDB 4fyt: Human Aminopeptidase N (CD13) in Complex with Amastatin

All present enzymatic activity of Human Aminopeptidase N (CD13) in Complex with Amastatin:
3.4.11.2;

The structure of Human Aminopeptidase N (CD13) in Complex with Amastatin, PDB code: 4fyt was solved by A.H.Wong, J.M.Rini, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	47.04 / 1.85
Space group	P 64
Cell size a, b, c (Å), α, β, γ (°)	157.470, 157.470, 115.130, 90.00, 90.00, 120.00
R / Rfree (%)	16.9 / 18.3

The binding sites of Zinc atom in the Human Aminopeptidase N (CD13) in Complex with Amastatin (pdb code 4fyt). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Human Aminopeptidase N (CD13) in Complex with Amastatin, PDB code: 4fyt:

Zinc binding site 1 out of 1 in the Human Aminopeptidase N (CD13) in Complex with Amastatin


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human Aminopeptidase N (CD13) in Complex with Amastatin within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1012 b:13.4 occ:1.00 OE1 A:GLU411 1.9 12.9 1.0 O1 B:L2O1 2.0 16.6 1.0 NE2 A:HIS388 2.0 13.1 1.0 NE2 A:HIS392 2.1 13.2 1.0 O B:L2O1 2.3 17.3 1.0 CD A:GLU411 2.8 12.7 1.0 CD2 A:HIS388 2.9 13.6 1.0 C6 B:L2O1 2.9 16.2 1.0 C B:L2O1 2.9 16.6 1.0 OE2 A:GLU411 3.0 13.0 1.0 CD2 A:HIS392 3.0 13.3 1.0 CE1 A:HIS388 3.1 13.6 1.0 CE1 A:HIS392 3.1 13.7 1.0 C1 B:L2O1 3.6 16.0 1.0 N B:L2O1 3.8 13.8 1.0 OH A:TYR477 4.0 12.6 1.0 OE1 A:GLU389 4.0 18.3 1.0 CE2 A:TYR477 4.1 13.0 1.0 CG A:HIS388 4.1 13.8 1.0 ND1 A:HIS388 4.2 13.8 1.0 CB A:ALA414 4.2 12.2 1.0 CG A:HIS392 4.2 13.1 1.0 ND1 A:HIS392 4.2 12.7 1.0 CG A:GLU411 4.2 12.6 1.0 N B:VAL2 4.3 19.3 1.0 CZ A:TYR477 4.4 13.0 1.0 OE2 A:GLU389 4.5 15.7 1.0 OE1 A:GLU355 4.5 14.4 1.0 CA A:GLU411 4.6 12.2 1.0 CD A:GLU389 4.7 16.2 1.0 CB A:GLU411 4.7 12.4 1.0 O A:HOH1162 5.0 15.2 1.0

A.H.Wong, D.Zhou, J.M.Rini. The X-Ray Crystal Structure of Human Aminopeptidase N Reveals A Novel Dimer and the Basis For Peptide Processing. J.Biol.Chem. V. 287 36804 2012.
ISSN: ISSN 0021-9258
PubMed: 22932899
DOI: 10.1074/JBC.M112.398842