Zinc in PDB 4fyq: Human Aminopeptidase N (CD13)

All present enzymatic activity of Human Aminopeptidase N (CD13):
3.4.11.2;

The structure of Human Aminopeptidase N (CD13), PDB code: 4fyq was solved by A.H.Wong, J.M.Rini, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	26.61 / 1.90
Space group	P 64
Cell size a, b, c (Å), α, β, γ (°)	157.901, 157.901, 115.047, 90.00, 90.00, 120.00
R / Rfree (%)	17 / 19.3

The binding sites of Zinc atom in the Human Aminopeptidase N (CD13) (pdb code 4fyq). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Human Aminopeptidase N (CD13), PDB code: 4fyq:

Zinc binding site 1 out of 1 in the Human Aminopeptidase N (CD13)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human Aminopeptidase N (CD13) within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1012 b:12.5 occ:1.00 OE1 A:GLU411 1.9 10.9 1.0 OXT A:ACY1024 2.0 16.1 1.0 NE2 A:HIS388 2.0 10.4 1.0 NE2 A:HIS392 2.1 11.3 1.0 O A:ACY1024 2.5 16.5 1.0 C A:ACY1024 2.6 17.0 1.0 CD A:GLU411 2.8 11.5 1.0 CD2 A:HIS388 3.0 10.9 1.0 OE2 A:GLU411 3.0 12.0 1.0 CE1 A:HIS392 3.0 11.5 1.0 CE1 A:HIS388 3.0 11.4 1.0 CD2 A:HIS392 3.1 11.6 1.0 O A:HOH1118 3.7 12.3 1.0 CE2 A:TYR477 3.8 11.5 1.0 OH A:TYR477 4.0 11.8 1.0 CH3 A:ACY1024 4.0 19.9 1.0 CB A:ALA414 4.1 11.2 1.0 ND1 A:HIS392 4.1 11.3 1.0 ND1 A:HIS388 4.1 11.2 1.0 CG A:HIS388 4.1 11.4 1.0 CG A:HIS392 4.2 11.5 1.0 CG A:GLU411 4.2 11.7 1.0 CZ A:TYR477 4.2 11.7 1.0 OE1 A:GLU355 4.5 13.0 1.0 CA A:GLU411 4.6 11.9 1.0 CD2 A:TYR477 4.7 11.6 1.0 CB A:GLU411 4.7 11.7 1.0 OE2 A:GLU389 4.8 13.7 1.0 O A:HOH1192 5.0 14.3 1.0

A.H.Wong, D.Zhou, J.M.Rini. The X-Ray Crystal Structure of Human Aminopeptidase N Reveals A Novel Dimer and the Basis For Peptide Processing. J.Biol.Chem. V. 287 36804 2012.
ISSN: ISSN 0021-9258
PubMed: 22932899
DOI: 10.1074/JBC.M112.398842