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Zinc in PDB 4fuk: Aminopeptidase From Trypanosoma Brucei

Enzymatic activity of Aminopeptidase From Trypanosoma Brucei

All present enzymatic activity of Aminopeptidase From Trypanosoma Brucei:
3.4.11.18;

Protein crystallography data

The structure of Aminopeptidase From Trypanosoma Brucei, PDB code: 4fuk was solved by M.El Bakkouri, W.Tempel, K.T.Osman, P.Loppnau, S.Graslund, C.H.Arrowsmith, A.M.Edwards, C.Bountra, R.Hui, Y.H.Lin, Structural Genomics Consortium(Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 47.19 / 1.75
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 48.385, 75.545, 180.997, 90.00, 90.00, 90.00
R / Rfree (%) 19.4 / 22.9

Zinc Binding Sites:

The binding sites of Zinc atom in the Aminopeptidase From Trypanosoma Brucei (pdb code 4fuk). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Aminopeptidase From Trypanosoma Brucei, PDB code: 4fuk:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in 4fuk

Go back to Zinc Binding Sites List in 4fuk
Zinc binding site 1 out of 4 in the Aminopeptidase From Trypanosoma Brucei


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Aminopeptidase From Trypanosoma Brucei within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn401

b:30.9
occ:1.00
OE2 A:GLU318 2.0 30.4 1.0
NE2 A:HIS285 2.0 24.2 1.0
OD2 A:ASP222 2.0 30.7 1.0
OE2 A:GLU349 2.2 28.1 1.0
CD A:GLU318 2.9 29.2 1.0
CE1 A:HIS285 3.0 26.1 1.0
CD2 A:HIS285 3.0 26.4 1.0
CG A:ASP222 3.0 32.2 1.0
CD A:GLU349 3.1 31.0 1.0
ZN A:ZN402 3.2 32.7 1.0
OE1 A:GLU318 3.2 28.9 1.0
OE1 A:GLU349 3.4 31.0 1.0
OD1 A:ASP222 3.5 31.3 1.0
OG1 A:THR316 3.7 29.6 1.0
O A:HOH547 3.8 29.7 1.0
CG2 A:THR316 3.9 29.2 1.0
ND1 A:HIS285 4.1 23.6 1.0
CB A:THR316 4.1 32.9 1.0
CG A:HIS285 4.2 25.8 1.0
CG A:GLU318 4.2 31.8 1.0
CB A:ASP222 4.3 32.0 1.0
CG A:GLU349 4.4 32.7 1.0
CA B:ALA60 4.5 30.7 1.0
N B:ALA60 4.5 33.5 1.0
NE2 A:HIS292 4.6 41.1 1.0
CD2 A:HIS292 4.9 39.3 1.0
CB A:GLU318 4.9 31.3 1.0
OD2 A:ASP211 5.0 35.1 1.0

Zinc binding site 2 out of 4 in 4fuk

Go back to Zinc Binding Sites List in 4fuk
Zinc binding site 2 out of 4 in the Aminopeptidase From Trypanosoma Brucei


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Aminopeptidase From Trypanosoma Brucei within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn402

b:32.7
occ:1.00
OD1 A:ASP211 2.0 29.4 1.0
OD1 A:ASP222 2.0 31.3 1.0
OE1 A:GLU349 2.2 31.0 1.0
OD2 A:ASP211 2.5 35.1 1.0
CG A:ASP211 2.6 32.1 1.0
CG A:ASP222 2.9 32.2 1.0
CD A:GLU349 3.1 31.0 1.0
OD2 A:ASP222 3.1 30.7 1.0
ZN A:ZN401 3.2 30.9 1.0
OE2 A:GLU349 3.3 28.1 1.0
OG A:SER213 3.9 37.1 1.0
ND2 A:ASN224 4.0 29.9 1.0
O A:HOH547 4.0 29.7 1.0
CB A:ASP211 4.1 30.6 1.0
OE1 A:GLU318 4.2 28.9 1.0
O A:HOH527 4.2 40.0 1.0
N A:LEU223 4.3 30.6 1.0
CB A:ASP222 4.3 32.0 1.0
O A:VAL212 4.4 32.0 1.0
O A:LEU223 4.5 30.8 1.0
CG A:GLU349 4.5 32.7 1.0
OE2 A:GLU318 4.5 30.4 1.0
C A:LEU223 4.6 31.1 1.0
O A:HOH542 4.7 30.4 1.0
C A:ASP222 4.7 30.2 1.0
CD A:GLU318 4.7 29.2 1.0
CB A:ASN224 4.8 31.1 1.0
CA A:ASP211 4.8 32.3 1.0
CA A:ASP222 4.8 32.4 1.0
N B:ALA60 4.8 33.5 1.0
CA A:LEU223 4.8 31.3 1.0
C A:ASP211 4.8 33.6 1.0
CG A:ASN224 4.9 32.3 1.0
N A:VAL212 5.0 32.1 1.0

Zinc binding site 3 out of 4 in 4fuk

Go back to Zinc Binding Sites List in 4fuk
Zinc binding site 3 out of 4 in the Aminopeptidase From Trypanosoma Brucei


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Aminopeptidase From Trypanosoma Brucei within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn401

b:17.6
occ:1.00
NE2 B:HIS285 2.1 14.5 1.0
OE2 B:GLU349 2.1 18.1 1.0
OD2 B:ASP222 2.1 19.1 1.0
OE1 B:GLU318 2.1 16.8 1.0
CD2 B:HIS285 3.0 15.8 1.0
CD B:GLU349 3.0 16.1 1.0
CD B:GLU318 3.0 16.1 1.0
CG B:ASP222 3.1 17.9 1.0
CE1 B:HIS285 3.1 16.5 1.0
ZN B:ZN402 3.1 17.9 1.0
OE2 B:GLU318 3.3 16.6 1.0
OE1 B:GLU349 3.4 15.3 1.0
OD1 B:ASP222 3.4 16.4 1.0
O B:HOH523 3.6 20.0 1.0
OG1 B:THR316 3.7 15.1 1.0
CG2 B:THR316 3.8 14.9 1.0
CB B:THR316 4.1 14.1 1.0
CG B:HIS285 4.1 15.0 1.0
ND1 B:HIS285 4.2 15.4 1.0
O B:HOH537 4.2 18.2 1.0
CB B:ASP222 4.2 16.5 1.0
CG B:GLU349 4.3 14.3 1.0
CG B:GLU318 4.4 16.9 1.0
CA A:ALA60 4.5 22.0 1.0
N A:ALA60 4.7 21.9 1.0
NE2 B:HIS292 4.9 26.2 1.0
OD2 B:ASP211 5.0 19.2 1.0

Zinc binding site 4 out of 4 in 4fuk

Go back to Zinc Binding Sites List in 4fuk
Zinc binding site 4 out of 4 in the Aminopeptidase From Trypanosoma Brucei


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Aminopeptidase From Trypanosoma Brucei within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn402

b:17.9
occ:1.00
OD1 B:ASP222 1.9 16.4 1.0
OD1 B:ASP211 2.1 18.9 1.0
OE1 B:GLU349 2.1 15.3 1.0
O B:HOH537 2.2 18.2 1.0
OD2 B:ASP211 2.5 19.2 1.0
CG B:ASP211 2.7 16.8 1.0
CG B:ASP222 2.8 17.9 1.0
CD B:GLU349 3.0 16.1 1.0
OD2 B:ASP222 3.0 19.1 1.0
ZN B:ZN401 3.1 17.6 1.0
OE2 B:GLU349 3.3 18.1 1.0
OG B:SER213 3.8 22.5 1.0
O B:HOH523 3.9 20.0 1.0
ND2 B:ASN224 4.1 13.3 1.0
OE2 B:GLU318 4.1 16.6 1.0
CB B:ASP211 4.2 15.2 1.0
CB B:ASP222 4.2 16.5 1.0
N B:LEU223 4.3 13.5 1.0
O B:HOH542 4.3 27.8 1.0
O B:LEU223 4.3 13.5 1.0
O B:HOH647 4.4 30.9 1.0
CG B:GLU349 4.5 14.3 1.0
O B:VAL212 4.5 13.9 1.0
OE1 B:GLU318 4.5 16.8 1.0
C B:LEU223 4.6 12.2 1.0
C B:ASP222 4.7 14.2 1.0
CD B:GLU318 4.7 16.1 1.0
O B:HOH510 4.7 18.9 1.0
CA B:ASP222 4.7 14.7 1.0
CB B:ASN224 4.7 12.3 1.0
CA B:ASP211 4.8 14.4 1.0
CA B:LEU223 4.8 12.1 1.0
N A:ALA60 4.9 21.9 1.0
CG B:ASN224 4.9 12.2 1.0
CB B:GLU349 4.9 13.0 1.0
C B:ASP211 5.0 14.8 1.0
NE2 B:HIS285 5.0 14.5 1.0

Reference:

M.El Bakkouri, W.Tempel, K.T.Osman, P.Loppnau, S.Graslund, C.H.Arrowsmith, A.M.Edwards, C.Bountra, R.Hui, Y.H.Lin, Structural Genomics Consortium (Sgc). Aminpeptidase From Trypanosoma Brucei (Casp Target) To Be Published.
Page generated: Wed Dec 16 05:18:09 2020

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