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Zinc in PDB 4yo8: Crystal Structure of Helicobacter Pylori 5'-Methylthioadenosine/S- Adenosyl Homocysteine Nucleosidase (Mtan) Complexed with (((4-Amino- 5H-Pyrrolo[3,2-D]Pyrimidin-7-Yl)Methyl)(Hexyl)Amino)Methanol
Enzymatic activity of Crystal Structure of Helicobacter Pylori 5'-Methylthioadenosine/S- Adenosyl Homocysteine Nucleosidase (Mtan) Complexed with (((4-Amino- 5H-Pyrrolo[3,2-D]Pyrimidin-7-Yl)Methyl)(Hexyl)Amino)Methanol
All present enzymatic activity of Crystal Structure of Helicobacter Pylori 5'-Methylthioadenosine/S- Adenosyl Homocysteine Nucleosidase (Mtan) Complexed with (((4-Amino- 5H-Pyrrolo[3,2-D]Pyrimidin-7-Yl)Methyl)(Hexyl)Amino)Methanol:
3.2.2.30; 3.2.2.9;
3.2.2.30; 3.2.2.9;
Protein crystallography data
The structure of Crystal Structure of Helicobacter Pylori 5'-Methylthioadenosine/S- Adenosyl Homocysteine Nucleosidase (Mtan) Complexed with (((4-Amino- 5H-Pyrrolo[3,2-D]Pyrimidin-7-Yl)Methyl)(Hexyl)Amino)Methanol, PDB code: 4yo8
was solved by
S.A.Cameron,
S.Wang,
S.C.Almo,
V.L.Schramm,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 25.00 / 2.10 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 65.091, 69.446, 65.566, 90.00, 113.08, 90.00 |
| R / Rfree (%) | 18.7 / 22.4 |
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of Helicobacter Pylori 5'-Methylthioadenosine/S- Adenosyl Homocysteine Nucleosidase (Mtan) Complexed with (((4-Amino- 5H-Pyrrolo[3,2-D]Pyrimidin-7-Yl)Methyl)(Hexyl)Amino)Methanol
(pdb code 4yo8). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Helicobacter Pylori 5'-Methylthioadenosine/S- Adenosyl Homocysteine Nucleosidase (Mtan) Complexed with (((4-Amino- 5H-Pyrrolo[3,2-D]Pyrimidin-7-Yl)Methyl)(Hexyl)Amino)Methanol, PDB code: 4yo8:
In total only one binding site of Zinc was determined in the Crystal Structure of Helicobacter Pylori 5'-Methylthioadenosine/S- Adenosyl Homocysteine Nucleosidase (Mtan) Complexed with (((4-Amino- 5H-Pyrrolo[3,2-D]Pyrimidin-7-Yl)Methyl)(Hexyl)Amino)Methanol, PDB code: 4yo8:
Zinc binding site 1 out of 1 in 4yo8
Go back to
Zinc Binding Sites List in 4yo8
Zinc binding site 1 out
of 1 in the Crystal Structure of Helicobacter Pylori 5'-Methylthioadenosine/S- Adenosyl Homocysteine Nucleosidase (Mtan) Complexed with (((4-Amino- 5H-Pyrrolo[3,2-D]Pyrimidin-7-Yl)Methyl)(Hexyl)Amino)Methanol
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of Crystal Structure of Helicobacter Pylori 5'-Methylthioadenosine/S- Adenosyl Homocysteine Nucleosidase (Mtan) Complexed with (((4-Amino- 5H-Pyrrolo[3,2-D]Pyrimidin-7-Yl)Methyl)(Hexyl)Amino)Methanol within 5.0Å range:
|
Reference:
S.Wang,
S.A.Cameron,
K.Clinch,
G.B.Evans,
Z.Wu,
V.L.Schramm,
P.C.Tyler.
New Antibiotic Candidates Against Helicobacter Pylori. J.Am.Chem.Soc. V. 137 14275 2015.
ISSN: ESSN 1520-5126
PubMed: 26494017
DOI: 10.1021/JACS.5B06110
Page generated: Sun Oct 27 11:19:51 2024
ISSN: ESSN 1520-5126
PubMed: 26494017
DOI: 10.1021/JACS.5B06110
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