Atomistry » Zinc » PDB 4fkd-4fvo » 4fpt
Atomistry »
  Zinc »
    PDB 4fkd-4fvo »
      4fpt »

Zinc in PDB 4fpt: Carbonic Anhydrase II in Complex with Ethyl (2Z,4R)-2- (Sulfamoylimino)-1,3-Thiazolidine-4-Carboxylate

Enzymatic activity of Carbonic Anhydrase II in Complex with Ethyl (2Z,4R)-2- (Sulfamoylimino)-1,3-Thiazolidine-4-Carboxylate

All present enzymatic activity of Carbonic Anhydrase II in Complex with Ethyl (2Z,4R)-2- (Sulfamoylimino)-1,3-Thiazolidine-4-Carboxylate:
4.2.1.1;

Protein crystallography data

The structure of Carbonic Anhydrase II in Complex with Ethyl (2Z,4R)-2- (Sulfamoylimino)-1,3-Thiazolidine-4-Carboxylate, PDB code: 4fpt was solved by A.Di Pizio, A.Heine, G.Klebe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 30.00 / 0.98
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 42.256, 41.607, 72.153, 90.00, 104.22, 90.00
R / Rfree (%) 12.8 / 15.8

Other elements in 4fpt:

The structure of Carbonic Anhydrase II in Complex with Ethyl (2Z,4R)-2- (Sulfamoylimino)-1,3-Thiazolidine-4-Carboxylate also contains other interesting chemical elements:

Mercury (Hg) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Carbonic Anhydrase II in Complex with Ethyl (2Z,4R)-2- (Sulfamoylimino)-1,3-Thiazolidine-4-Carboxylate (pdb code 4fpt). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Carbonic Anhydrase II in Complex with Ethyl (2Z,4R)-2- (Sulfamoylimino)-1,3-Thiazolidine-4-Carboxylate, PDB code: 4fpt:

Zinc binding site 1 out of 1 in 4fpt

Go back to Zinc Binding Sites List in 4fpt
Zinc binding site 1 out of 1 in the Carbonic Anhydrase II in Complex with Ethyl (2Z,4R)-2- (Sulfamoylimino)-1,3-Thiazolidine-4-Carboxylate


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Carbonic Anhydrase II in Complex with Ethyl (2Z,4R)-2- (Sulfamoylimino)-1,3-Thiazolidine-4-Carboxylate within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn302

b:4.6
occ:1.00
 N8 A:0VZ303 1.9 5.6 1.0
NE2 A:HIS94 2.0 4.9 1.0
ND1 A:HIS119 2.0 4.6 1.0
NE2 A:HIS96 2.0 5.0 1.0
CE1 A:HIS119 2.9 4.5 1.0
CD2 A:HIS94 3.0 5.0 1.0
CE1 A:HIS94 3.0 5.1 1.0
CE1 A:HIS96 3.0 5.9 1.0
S7 A:0VZ303 3.1 5.5 1.0
CD2 A:HIS96 3.1 4.7 1.0
O9 A:0VZ303 3.1 5.8 1.0
CG A:HIS119 3.1 4.5 1.0
CB A:HIS119 3.6 4.4 1.0
OG1 A:THR199 4.0 4.9 1.0
O10 A:0VZ303 4.0 6.9 1.0
OE1 A:GLU106 4.1 5.1 1.0
NE2 A:HIS119 4.1 4.7 1.0
CG A:HIS94 4.1 5.0 1.0
ND1 A:HIS94 4.1 5.4 1.0
N3 A:0VZ303 4.2 6.9 1.0
ND1 A:HIS96 4.2 6.4 1.0
CG A:HIS96 4.2 5.1 1.0
CD2 A:HIS119 4.2 4.8 1.0
C3 A:GOL304 4.4 10.4 0.7
C2 A:GOL304 4.9 9.6 0.7
C2 A:0VZ303 5.0 6.6 1.0
CD A:GLU106 5.0 4.7 1.0

Reference:

A.Di Pizio, J.Schulze Wischeler, M.Haake, A.Heine, G.Klebe. High Resolution Crystal Structures of Carbonic Anhydrase II in Complex with Novel Sulfamide Binders To Be Published.
Page generated: Sat Oct 26 22:51:29 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy