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Zinc in PDB 4fkd: Identification of the Activator Binding Residues in the Second Cysteine-Rich Regulatory Domain of Protein Kinase C Theta

Enzymatic activity of Identification of the Activator Binding Residues in the Second Cysteine-Rich Regulatory Domain of Protein Kinase C Theta

All present enzymatic activity of Identification of the Activator Binding Residues in the Second Cysteine-Rich Regulatory Domain of Protein Kinase C Theta:
2.7.11.13;

Protein crystallography data

The structure of Identification of the Activator Binding Residues in the Second Cysteine-Rich Regulatory Domain of Protein Kinase C Theta, PDB code: 4fkd was solved by G.M.Rahman, S.Shanker, N.E.Lewin, B.V.V.Prasad, P.M.Blumberg, J.Das, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 28.51 / 1.63
Space group P 61
Cell size a, b, c (Å), α, β, γ (°) 65.850, 65.850, 27.120, 90.00, 90.00, 120.00
R / Rfree (%) 17.1 / 20.4

Zinc Binding Sites:

The binding sites of Zinc atom in the Identification of the Activator Binding Residues in the Second Cysteine-Rich Regulatory Domain of Protein Kinase C Theta (pdb code 4fkd). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Identification of the Activator Binding Residues in the Second Cysteine-Rich Regulatory Domain of Protein Kinase C Theta, PDB code: 4fkd:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 4fkd

Go back to Zinc Binding Sites List in 4fkd
Zinc binding site 1 out of 2 in the Identification of the Activator Binding Residues in the Second Cysteine-Rich Regulatory Domain of Protein Kinase C Theta


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Identification of the Activator Binding Residues in the Second Cysteine-Rich Regulatory Domain of Protein Kinase C Theta within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn101

b:14.1
occ:1.00
ND1 A:HIS48 2.2 14.2 1.0
SG A:CYS51 2.3 13.1 1.0
SG A:CYS26 2.4 12.2 1.0
SG A:CYS23 2.4 11.7 1.0
CB A:CYS23 3.0 9.7 1.0
CE1 A:HIS48 3.1 10.3 1.0
CG A:HIS48 3.2 13.1 1.0
CB A:CYS26 3.2 11.6 1.0
CB A:CYS51 3.4 12.1 1.0
CB A:HIS48 3.5 11.8 1.0
N A:CYS26 3.8 8.8 1.0
N A:HIS48 4.0 9.9 1.0
CA A:CYS26 4.0 11.3 1.0
NE2 A:HIS48 4.2 12.6 1.0
CD2 A:HIS48 4.3 13.6 1.0
CA A:HIS48 4.4 8.1 1.0
CA A:CYS23 4.5 8.7 1.0
O A:HOH244 4.6 28.0 1.0
OG1 A:THR28 4.7 11.8 1.0
CB A:HIS25 4.7 9.2 1.0
CA A:CYS51 4.8 12.4 1.0
C A:CYS26 4.8 13.2 1.0
N A:GLY27 4.9 11.1 1.0
C A:HIS25 4.9 9.9 1.0
NH2 A:ARG50 4.9 33.4 1.0
CD2 A:HIS25 5.0 13.8 1.0
O A:HOH253 5.0 33.8 1.0

Zinc binding site 2 out of 2 in 4fkd

Go back to Zinc Binding Sites List in 4fkd
Zinc binding site 2 out of 2 in the Identification of the Activator Binding Residues in the Second Cysteine-Rich Regulatory Domain of Protein Kinase C Theta


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Identification of the Activator Binding Residues in the Second Cysteine-Rich Regulatory Domain of Protein Kinase C Theta within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn102

b:12.4
occ:1.00
ND1 A:HIS10 2.2 12.4 1.0
SG A:CYS59 2.3 10.7 1.0
SG A:CYS40 2.4 10.1 1.0
SG A:CYS43 2.4 12.3 1.0
CE1 A:HIS10 3.1 9.6 1.0
CG A:HIS10 3.2 12.2 1.0
CB A:CYS59 3.2 11.9 1.0
CB A:CYS43 3.2 8.5 1.0
CB A:CYS40 3.2 11.4 1.0
CB A:HIS10 3.5 10.6 1.0
N A:CYS43 3.7 11.2 1.0
CA A:HIS10 3.8 12.1 1.0
CA A:CYS59 4.0 11.9 1.0
CA A:CYS43 4.0 9.3 1.0
NE2 A:HIS10 4.2 11.8 1.0
O A:HOH212 4.2 12.7 1.0
CD2 A:HIS10 4.3 14.9 1.0
CB A:ALA42 4.4 13.1 1.0
N A:ARG11 4.6 9.7 1.0
O A:HOH206 4.6 12.2 1.0
C A:ALA42 4.6 10.2 1.0
CA A:CYS40 4.7 10.0 1.0
C A:CYS59 4.7 13.1 1.0
CB A:MET45 4.8 11.0 1.0
C A:CYS43 4.8 11.0 1.0
C A:HIS10 4.8 12.9 1.0
N A:HIS10 4.8 11.2 1.0
CA A:ALA42 4.9 9.2 1.0
N A:GLY44 4.9 9.8 1.0
N A:GLU60 4.9 15.7 1.0
N A:ALA42 5.0 10.5 1.0

Reference:

G.M.Rahman, S.Shanker, N.E.Lewin, N.Kedei, C.S.Hill, B.V.Prasad, P.M.Blumberg, J.Das. Identification of the Activator Binding Residues in the Second Cysteine-Rich Regulatory Domain of Protein Kinase C Theta. Biochem.J. V. 451 33 2013.
ISSN: ISSN 0264-6021
PubMed: 23289588
DOI: 10.1042/BJ20121307
Page generated: Wed Dec 16 05:17:45 2020

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