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Atomistry » Zinc » PDB 4eez-4eyf » 4ewq » |
Zinc in PDB 4ewq: Human P38 Alpha Mapk in Complex with A Pyridazine Based InhibitorEnzymatic activity of Human P38 Alpha Mapk in Complex with A Pyridazine Based Inhibitor
All present enzymatic activity of Human P38 Alpha Mapk in Complex with A Pyridazine Based Inhibitor:
2.7.11.24; Protein crystallography data
The structure of Human P38 Alpha Mapk in Complex with A Pyridazine Based Inhibitor, PDB code: 4ewq
was solved by
V.Grum-Tokars,
G.Minasov,
S.Roy,
J.Schavocky,
J.Winsor,
D.M.Watterson,
W.F.Anderson,
Center For Structural Genomics Of Infectious Diseases(Csgid),
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4ewq:
The structure of Human P38 Alpha Mapk in Complex with A Pyridazine Based Inhibitor also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Human P38 Alpha Mapk in Complex with A Pyridazine Based Inhibitor
(pdb code 4ewq). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Human P38 Alpha Mapk in Complex with A Pyridazine Based Inhibitor, PDB code: 4ewq: Zinc binding site 1 out of 1 in 4ewqGo back to![]() ![]()
Zinc binding site 1 out
of 1 in the Human P38 Alpha Mapk in Complex with A Pyridazine Based Inhibitor
![]() Mono view ![]() Stereo pair view
Reference:
S.M.Roy,
G.Minasov,
O.Arancio,
L.W.Chico,
L.J.Van Eldik,
W.F.Anderson,
J.C.Pelletier,
D.M.Watterson.
A Selective and Brain Penetrant P38 Alpha Mapk Inhibitor Candidate For Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction. J.Med.Chem. V. 62 5298 2019.
Page generated: Wed Dec 16 05:16:19 2020
ISSN: ISSN 0022-2623 PubMed: 30978288 DOI: 10.1021/ACS.JMEDCHEM.9B00058 |
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