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Zinc in PDB 4e2v: Trna-Guanine Transglycosylase Y106F, C158V Mutant in Complex with PREQ1

Enzymatic activity of Trna-Guanine Transglycosylase Y106F, C158V Mutant in Complex with PREQ1

All present enzymatic activity of Trna-Guanine Transglycosylase Y106F, C158V Mutant in Complex with PREQ1:
2.4.2.29;

Protein crystallography data

The structure of Trna-Guanine Transglycosylase Y106F, C158V Mutant in Complex with PREQ1, PDB code: 4e2v was solved by I.Schmidt, K.Reuter, G.Klebe, A.Heine, N.Tidten, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 21.03 / 1.18
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 90.363, 64.894, 70.375, 90.00, 95.82, 90.00
R / Rfree (%) 13.8 / 15.3

Zinc Binding Sites:

The binding sites of Zinc atom in the Trna-Guanine Transglycosylase Y106F, C158V Mutant in Complex with PREQ1 (pdb code 4e2v). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Trna-Guanine Transglycosylase Y106F, C158V Mutant in Complex with PREQ1, PDB code: 4e2v:

Zinc binding site 1 out of 1 in 4e2v

Go back to Zinc Binding Sites List in 4e2v
Zinc binding site 1 out of 1 in the Trna-Guanine Transglycosylase Y106F, C158V Mutant in Complex with PREQ1


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Trna-Guanine Transglycosylase Y106F, C158V Mutant in Complex with PREQ1 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn405

b:10.0
occ:1.00
ND1 A:HIS349 2.2 9.8 1.0
SG A:CYS323 2.3 10.7 1.0
SG A:CYS320 2.3 10.0 1.0
SG A:CYS318 2.3 11.6 1.0
CE1 A:HIS349 3.0 10.5 1.0
CB A:CYS318 3.3 12.0 1.0
CB A:CYS323 3.3 10.9 1.0
CG A:HIS349 3.3 9.1 1.0
CB A:CYS320 3.4 10.5 1.0
CB A:HIS349 3.7 9.2 1.0
N A:CYS323 3.9 10.2 1.0
CA A:HIS349 4.1 8.5 1.0
N A:CYS320 4.1 12.2 1.0
NE2 A:HIS349 4.2 10.1 1.0
CA A:CYS323 4.2 10.7 1.0
CA A:CYS320 4.2 11.0 1.0
CD2 A:HIS349 4.3 9.6 1.0
O A:HIS349 4.5 8.9 1.0
CA A:CYS318 4.6 12.9 1.0
C A:CYS318 4.7 12.9 1.0
C A:CYS320 4.7 10.6 1.0
O A:CYS320 4.7 11.1 1.0
O A:CYS318 4.8 13.4 1.0
C A:HIS349 4.8 8.3 1.0
CB A:VAL322 4.8 10.1 1.0
C A:VAL322 4.9 10.3 1.0

Reference:

I.Biela, N.Tidten-Luksch, F.Immekus, S.Glinca, T.X.Nguyen, H.D.Gerber, A.Heine, G.Klebe, K.Reuter. Investigation of Specificity Determinants in Bacterial Trna-Guanine Transglycosylase Reveals Queuine, the Substrate of Its Eucaryotic Counterpart, As Inhibitor. Plos One V. 8 64240 2013.
ISSN: ESSN 1932-6203
PubMed: 23704982
DOI: 10.1371/JOURNAL.PONE.0064240
Page generated: Wed Dec 16 05:15:24 2020

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