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Zinc in PDB 4cbt: Design, Synthesis, and Biological Evaluation of Potent and Selective Class Iia Hdac Inhibitors As A Potential Therapy For Huntingtons Disease
Enzymatic activity of Design, Synthesis, and Biological Evaluation of Potent and Selective Class Iia Hdac Inhibitors As A Potential Therapy For Huntingtons Disease
All present enzymatic activity of Design, Synthesis, and Biological Evaluation of Potent and Selective Class Iia Hdac Inhibitors As A Potential Therapy For Huntingtons Disease:
3.5.1.98;
3.5.1.98;
Protein crystallography data
The structure of Design, Synthesis, and Biological Evaluation of Potent and Selective Class Iia Hdac Inhibitors As A Potential Therapy For Huntingtons Disease, PDB code: 4cbt
was solved by
R.W.Burli,
C.A.Luckhurst,
O.Aziz,
K.L.Matthews,
D.Yates,
K.A.Lyons,
M.Beconi,
G.Mcallister,
P.Breccia,
A.J.Stott,
S.D.Penrose,
M.Wall,
M.Lamers,
P.Leonard,
I.Mueller,
C.M.Richardson,
R.Jarvis,
L.Stones,
S.Hughes,
G.Wishart,
A.F.Haughan,
C.Oconnell,
T.Mead,
H.Mcneil,
J.Vann,
J.Mangette,
M.Maillard,
V.Beaumont,
I.Munoz-Sanjuan,
C.Dominguez,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 90.42 / 3.03 |
| Space group | P 32 |
| Cell size a, b, c (Å), α, β, γ (°) | 104.410, 104.410, 88.440, 90.00, 90.00, 120.00 |
| R / Rfree (%) | 21.139 / 27.335 |
Other elements in 4cbt:
The structure of Design, Synthesis, and Biological Evaluation of Potent and Selective Class Iia Hdac Inhibitors As A Potential Therapy For Huntingtons Disease also contains other interesting chemical elements:
| Fluorine | (F) | 3 atoms |
Zinc Binding Sites:
The binding sites of Zinc atom in the Design, Synthesis, and Biological Evaluation of Potent and Selective Class Iia Hdac Inhibitors As A Potential Therapy For Huntingtons Disease
(pdb code 4cbt). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 6 binding sites of Zinc where determined in the Design, Synthesis, and Biological Evaluation of Potent and Selective Class Iia Hdac Inhibitors As A Potential Therapy For Huntingtons Disease, PDB code: 4cbt:
Jump to Zinc binding site number: 1; 2; 3; 4; 5; 6;
In total 6 binding sites of Zinc where determined in the Design, Synthesis, and Biological Evaluation of Potent and Selective Class Iia Hdac Inhibitors As A Potential Therapy For Huntingtons Disease, PDB code: 4cbt:
Jump to Zinc binding site number: 1; 2; 3; 4; 5; 6;
Zinc binding site 1 out of 6 in 4cbt
Go back to
Zinc Binding Sites List in 4cbt
Zinc binding site 1 out
of 6 in the Design, Synthesis, and Biological Evaluation of Potent and Selective Class Iia Hdac Inhibitors As A Potential Therapy For Huntingtons Disease
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of Design, Synthesis, and Biological Evaluation of Potent and Selective Class Iia Hdac Inhibitors As A Potential Therapy For Huntingtons Disease within 5.0Å range:
|
Zinc binding site 2 out of 6 in 4cbt
Go back to
Zinc Binding Sites List in 4cbt
Zinc binding site 2 out
of 6 in the Design, Synthesis, and Biological Evaluation of Potent and Selective Class Iia Hdac Inhibitors As A Potential Therapy For Huntingtons Disease
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 2 of Design, Synthesis, and Biological Evaluation of Potent and Selective Class Iia Hdac Inhibitors As A Potential Therapy For Huntingtons Disease within 5.0Å range:
|
Zinc binding site 3 out of 6 in 4cbt
Go back to
Zinc Binding Sites List in 4cbt
Zinc binding site 3 out
of 6 in the Design, Synthesis, and Biological Evaluation of Potent and Selective Class Iia Hdac Inhibitors As A Potential Therapy For Huntingtons Disease
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 3 of Design, Synthesis, and Biological Evaluation of Potent and Selective Class Iia Hdac Inhibitors As A Potential Therapy For Huntingtons Disease within 5.0Å range:
|
Zinc binding site 4 out of 6 in 4cbt
Go back to
Zinc Binding Sites List in 4cbt
Zinc binding site 4 out
of 6 in the Design, Synthesis, and Biological Evaluation of Potent and Selective Class Iia Hdac Inhibitors As A Potential Therapy For Huntingtons Disease
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 4 of Design, Synthesis, and Biological Evaluation of Potent and Selective Class Iia Hdac Inhibitors As A Potential Therapy For Huntingtons Disease within 5.0Å range:
|
Zinc binding site 5 out of 6 in 4cbt
Go back to
Zinc Binding Sites List in 4cbt
Zinc binding site 5 out
of 6 in the Design, Synthesis, and Biological Evaluation of Potent and Selective Class Iia Hdac Inhibitors As A Potential Therapy For Huntingtons Disease
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 5 of Design, Synthesis, and Biological Evaluation of Potent and Selective Class Iia Hdac Inhibitors As A Potential Therapy For Huntingtons Disease within 5.0Å range:
|
Zinc binding site 6 out of 6 in 4cbt
Go back to
Zinc Binding Sites List in 4cbt
Zinc binding site 6 out
of 6 in the Design, Synthesis, and Biological Evaluation of Potent and Selective Class Iia Hdac Inhibitors As A Potential Therapy For Huntingtons Disease
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 6 of Design, Synthesis, and Biological Evaluation of Potent and Selective Class Iia Hdac Inhibitors As A Potential Therapy For Huntingtons Disease within 5.0Å range:
|
Reference:
R.W.Burli,
C.A.Luckhurst,
O.Aziz,
K.L.Matthews,
D.Yates,
K.A.Lyons,
M.Beconi,
G.Mcallister,
P.Breccia,
A.J.Stott,
S.D.Penrose,
M.Wall,
M.B.A.C.Lamers,
P.Leonard,
I.Mueller,
C.M.Richardson,
R.Jarvis,
L.Stones,
S.Hughes,
G.Wishart,
A.F.Haughan,
C.O'connell,
T.Mead,
H.Mcneil,
J.Vann,
J.Mangette,
M.Maillard,
V.Beaumont,
I.Munoz-Sanjuan,
C.Dominguez.
Design, Synthesis, and Biological Evaluation of Potent and Selective Class Iia Histone Deacetylase (Hdac) Inhibitors As A Potential Therapy For Huntington'S Disease. J.Med.Chem. V. 56 9934 2013.
ISSN: ISSN 0022-2623
PubMed: 24261862
DOI: 10.1021/JM4011884
Page generated: Sat Oct 26 20:45:33 2024
ISSN: ISSN 0022-2623
PubMed: 24261862
DOI: 10.1021/JM4011884
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