Atomistry » Zinc » PDB 4b3s-4bin » 4b7k
Atomistry »
  Zinc »
    PDB 4b3s-4bin »
      4b7k »

Zinc in PDB 4b7k: Factor Inhibiting Hif-1 Alpha in Complex with Consensus Ankyrin Repeat Domain-Ser Peptide (20-Mer)

Enzymatic activity of Factor Inhibiting Hif-1 Alpha in Complex with Consensus Ankyrin Repeat Domain-Ser Peptide (20-Mer)

All present enzymatic activity of Factor Inhibiting Hif-1 Alpha in Complex with Consensus Ankyrin Repeat Domain-Ser Peptide (20-Mer):
1.14.11.16; 1.14.11.30;

Protein crystallography data

The structure of Factor Inhibiting Hif-1 Alpha in Complex with Consensus Ankyrin Repeat Domain-Ser Peptide (20-Mer), PDB code: 4b7k was solved by R.Chowdhury, W.Ge, C.J.Schofield, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 29.91 / 2.39
Space group P 41 21 2
Cell size a, b, c (Å), α, β, γ (°) 86.355, 86.355, 148.308, 90.00, 90.00, 90.00
R / Rfree (%) 22.5 / 24.1

Zinc Binding Sites:

The binding sites of Zinc atom in the Factor Inhibiting Hif-1 Alpha in Complex with Consensus Ankyrin Repeat Domain-Ser Peptide (20-Mer) (pdb code 4b7k). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Factor Inhibiting Hif-1 Alpha in Complex with Consensus Ankyrin Repeat Domain-Ser Peptide (20-Mer), PDB code: 4b7k:

Zinc binding site 1 out of 1 in 4b7k

Go back to Zinc Binding Sites List in 4b7k
Zinc binding site 1 out of 1 in the Factor Inhibiting Hif-1 Alpha in Complex with Consensus Ankyrin Repeat Domain-Ser Peptide (20-Mer)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Factor Inhibiting Hif-1 Alpha in Complex with Consensus Ankyrin Repeat Domain-Ser Peptide (20-Mer) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn501

b:50.0
occ:1.00
 O2 A:OGA601 2.1 49.8 1.0
O2' A:OGA601 2.1 49.4 1.0
NE2 A:HIS279 2.2 42.4 1.0
OD2 A:ASP201 2.3 44.3 1.0
NE2 A:HIS199 2.3 45.8 1.0
C1 A:OGA601 2.8 48.5 1.0
C2 A:OGA601 2.8 49.1 1.0
OG B:SER16 2.9 76.5 0.5
CG A:ASP201 3.1 44.2 1.0
CE1 A:HIS279 3.1 41.5 1.0
OD1 A:ASP201 3.2 46.9 1.0
CD2 A:HIS279 3.2 42.3 1.0
CD2 A:HIS199 3.3 42.8 1.0
CE1 A:HIS199 3.3 44.8 1.0
O1 A:OGA601 4.0 51.0 1.0
CB B:SER16 4.1 78.5 0.5
N1 A:OGA601 4.1 47.1 1.0
CZ2 A:TRP296 4.2 46.9 1.0
O A:HOH2047 4.2 46.9 1.0
OG B:SER16 4.2 76.5 0.5
CB B:SER16 4.3 78.5 0.5
ND1 A:HIS279 4.3 44.5 1.0
CG A:HIS279 4.3 44.2 1.0
ND1 A:HIS199 4.4 44.3 1.0
CG A:HIS199 4.4 43.9 1.0
CB A:ASP201 4.5 45.4 1.0
C4 A:OGA601 4.9 48.7 1.0
CH2 A:TRP296 4.9 50.5 1.0
O A:HOH2035 5.0 71.9 1.0

Reference:

M.Yang, A.P.Hardy, R.Chowdhury, N.D.Loik, J.S.Scotti, J.S.Mccullagh, T.D.Claridge, M.A.Mcdonough, W.Ge, C.J.Schofield. Substrate Selectivity Analyses of Factor Inhibiting Hypoxia-Inducible Factor. Angew. Chem. Int. Ed. Engl. V. 52 1700 2013.
ISSN: ESSN 1521-3773
PubMed: 23296631
DOI: 10.1002/ANIE.201208046
Page generated: Sat Oct 26 19:34:28 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy