Atomistry » Zinc » PDB 4b3s-4bin » 4b7e
Atomistry »
  Zinc »
    PDB 4b3s-4bin »
      4b7e »

Zinc in PDB 4b7e: Factor Inhibiting Hif-1 Alpha in Complex with Consensus Ankyrin Repeat Domain-Leu Peptide (20-Mer)

Enzymatic activity of Factor Inhibiting Hif-1 Alpha in Complex with Consensus Ankyrin Repeat Domain-Leu Peptide (20-Mer)

All present enzymatic activity of Factor Inhibiting Hif-1 Alpha in Complex with Consensus Ankyrin Repeat Domain-Leu Peptide (20-Mer):
1.14.11.16; 1.14.11.30;

Protein crystallography data

The structure of Factor Inhibiting Hif-1 Alpha in Complex with Consensus Ankyrin Repeat Domain-Leu Peptide (20-Mer), PDB code: 4b7e was solved by R.Chowdhury, W.Ge, C.J.Schofield, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 23.12 / 2.50
Space group P 41 21 2
Cell size a, b, c (Å), α, β, γ (°) 86.448, 86.448, 143.958, 90.00, 90.00, 90.00
R / Rfree (%) 22.6 / 25.5

Zinc Binding Sites:

The binding sites of Zinc atom in the Factor Inhibiting Hif-1 Alpha in Complex with Consensus Ankyrin Repeat Domain-Leu Peptide (20-Mer) (pdb code 4b7e). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Factor Inhibiting Hif-1 Alpha in Complex with Consensus Ankyrin Repeat Domain-Leu Peptide (20-Mer), PDB code: 4b7e:

Zinc binding site 1 out of 1 in 4b7e

Go back to Zinc Binding Sites List in 4b7e
Zinc binding site 1 out of 1 in the Factor Inhibiting Hif-1 Alpha in Complex with Consensus Ankyrin Repeat Domain-Leu Peptide (20-Mer)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Factor Inhibiting Hif-1 Alpha in Complex with Consensus Ankyrin Repeat Domain-Leu Peptide (20-Mer) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn501

b:40.4
occ:1.00
 OD2 A:ASP201 2.1 24.9 1.0
NE2 A:HIS199 2.1 37.8 1.0
O2' A:OGA601 2.2 33.5 1.0
O2 A:OGA601 2.2 37.0 1.0
NE2 A:HIS279 2.3 34.3 1.0
C2 A:OGA601 2.8 34.5 1.0
C1 A:OGA601 2.8 36.0 1.0
CG A:ASP201 3.0 29.0 1.0
CE1 A:HIS199 3.1 39.5 1.0
CE1 A:HIS279 3.2 33.8 1.0
CD2 A:HIS199 3.2 38.0 1.0
OD1 A:ASP201 3.2 29.5 1.0
CD2 A:HIS279 3.3 33.9 1.0
O A:HOH2096 3.9 28.2 1.0
O1 A:OGA601 4.0 36.3 1.0
CB B:LEU16 4.1 41.1 1.0
N1 A:OGA601 4.1 33.3 1.0
ND1 A:HIS199 4.2 39.1 1.0
CG A:HIS199 4.3 38.0 1.0
ND1 A:HIS279 4.3 33.5 1.0
CZ2 A:TRP296 4.3 31.4 1.0
CB A:ASP201 4.4 29.1 1.0
CG A:HIS279 4.4 33.6 1.0
CD2 B:LEU16 4.6 39.0 1.0
CG B:LEU16 4.8 40.8 1.0
C4 A:OGA601 4.8 32.8 1.0
CD1 B:LEU16 5.0 40.4 1.0

Reference:

M.Yang, A.P.Hardy, R.Chowdhury, N.D.Loik, J.S.Scotti, J.S.Mccullagh, T.D.Claridge, M.A.Mcdonough, W.Ge, C.J.Schofield. Substrate Selectivity Analyses of Factor Inhibiting Hypoxia-Inducible Factor. Angew. Chem. Int. Ed. Engl. V. 52 1700 2013.
ISSN: ESSN 1521-3773
PubMed: 23296631
DOI: 10.1002/ANIE.201208046
Page generated: Wed Dec 16 05:04:50 2020

Last articles

Zn in 8WB0
Zn in 8WAX
Zn in 8WAU
Zn in 8WAZ
Zn in 8WAY
Zn in 8WAV
Zn in 8WAW
Zn in 8WAT
Zn in 8W7M
Zn in 8WD3
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy