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Atomistry » Zinc » PDB 4a3f-4aa6 » 4a4o » |
Zinc in PDB 4a4o: Crystal Structure of Polo-Like Kinase 1 in Complex with A 2-(2-Amino- Pyrimidin-4-Yl)-1,5,6,7-Tetrahydro-Pyrrolopyridin-4-One InhibitorEnzymatic activity of Crystal Structure of Polo-Like Kinase 1 in Complex with A 2-(2-Amino- Pyrimidin-4-Yl)-1,5,6,7-Tetrahydro-Pyrrolopyridin-4-One Inhibitor
All present enzymatic activity of Crystal Structure of Polo-Like Kinase 1 in Complex with A 2-(2-Amino- Pyrimidin-4-Yl)-1,5,6,7-Tetrahydro-Pyrrolopyridin-4-One Inhibitor:
2.7.11.21; Protein crystallography data
The structure of Crystal Structure of Polo-Like Kinase 1 in Complex with A 2-(2-Amino- Pyrimidin-4-Yl)-1,5,6,7-Tetrahydro-Pyrrolopyridin-4-One Inhibitor, PDB code: 4a4o
was solved by
J.A.Bertrand,
R.T.Bossi,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4a4o:
The structure of Crystal Structure of Polo-Like Kinase 1 in Complex with A 2-(2-Amino- Pyrimidin-4-Yl)-1,5,6,7-Tetrahydro-Pyrrolopyridin-4-One Inhibitor also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Crystal Structure of Polo-Like Kinase 1 in Complex with A 2-(2-Amino- Pyrimidin-4-Yl)-1,5,6,7-Tetrahydro-Pyrrolopyridin-4-One Inhibitor
(pdb code 4a4o). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Polo-Like Kinase 1 in Complex with A 2-(2-Amino- Pyrimidin-4-Yl)-1,5,6,7-Tetrahydro-Pyrrolopyridin-4-One Inhibitor, PDB code: 4a4o: Zinc binding site 1 out of 1 in 4a4oGo back to Zinc Binding Sites List in 4a4o
Zinc binding site 1 out
of 1 in the Crystal Structure of Polo-Like Kinase 1 in Complex with A 2-(2-Amino- Pyrimidin-4-Yl)-1,5,6,7-Tetrahydro-Pyrrolopyridin-4-One Inhibitor
Mono view Stereo pair view
Reference:
M.Caruso,
B.Valsasina,
D.Ballinari,
J.A.Bertrand,
M.G.Brasca,
M.Caldarelli,
P.Cappella,
F.Fiorentini,
L.M.Gianellini,
A.Scolaro,
I.Beria.
5-(2-Amino-Pyrimidin-4-Yl)-1H-Pyrrole and 2-(2-Amino-Pyrimidin-4-Yl)-1,5,6,7-Tetrahydro-Pyrrolo[3, 2-C]Pyridin-4-One Derivatives As New Classes of Selective and Orally Available Polo-Like Kinase 1 Inhibitors. Bioorg.Med.Chem.Lett. V. 22 96 2012.
Page generated: Wed Dec 16 05:02:23 2020
ISSN: ISSN 0960-894X PubMed: 22154349 DOI: 10.1016/J.BMCL.2011.11.065 |
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