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Zinc in PDB 3zqr: NMEPHEB25 Insulin Analogue Crystal Structure

Protein crystallography data

The structure of NMEPHEB25 Insulin Analogue Crystal Structure, PDB code: 3zqr was solved by E.Antolikova, L.Zakova, J.P.Turkenburg, C.J.Watson, I.Hanclova, M.Sanda, A.Cooper, T.Kraus, A.M.Brzozowski, J.A.Jiracek, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 54.29 / 1.90
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 46.600, 61.837, 58.224, 90.00, 111.19, 90.00
R / Rfree (%) 22.3 / 28.1

Other elements in 3zqr:

The structure of NMEPHEB25 Insulin Analogue Crystal Structure also contains other interesting chemical elements:

Chlorine (Cl) 2 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the NMEPHEB25 Insulin Analogue Crystal Structure (pdb code 3zqr). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the NMEPHEB25 Insulin Analogue Crystal Structure, PDB code: 3zqr:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 3zqr

Go back to Zinc Binding Sites List in 3zqr
Zinc binding site 1 out of 2 in the NMEPHEB25 Insulin Analogue Crystal Structure


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of NMEPHEB25 Insulin Analogue Crystal Structure within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn1030

b:22.7
occ:1.00
NE2 F:HIS10 2.0 23.3 1.0
NE2 J:HIS10 2.0 23.7 1.0
NE2 B:HIS10 2.1 18.4 1.0
CL B:CL1031 2.2 25.4 1.0
CE1 F:HIS10 2.9 23.5 1.0
CE1 J:HIS10 3.0 26.3 1.0
CD2 F:HIS10 3.0 21.1 1.0
CE1 B:HIS10 3.0 25.2 1.0
CD2 J:HIS10 3.1 21.3 1.0
CD2 B:HIS10 3.2 23.6 1.0
ND1 F:HIS10 4.1 22.8 1.0
ND1 J:HIS10 4.1 20.8 1.0
CG F:HIS10 4.1 21.3 1.0
CG J:HIS10 4.2 22.9 1.0
ND1 B:HIS10 4.2 22.5 1.0
CG B:HIS10 4.3 23.1 1.0
O F:LEU6 4.8 23.6 1.0
O B:LEU6 4.8 27.3 1.0
O J:LEU6 4.8 23.5 1.0

Zinc binding site 2 out of 2 in 3zqr

Go back to Zinc Binding Sites List in 3zqr
Zinc binding site 2 out of 2 in the NMEPHEB25 Insulin Analogue Crystal Structure


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of NMEPHEB25 Insulin Analogue Crystal Structure within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Zn1029

b:26.4
occ:1.00
NE2 H:HIS10 1.9 29.3 1.0
NE2 D:HIS10 2.1 26.3 1.0
NE2 L:HIS10 2.1 26.5 1.0
CL D:CL1030 2.2 31.5 1.0
CD2 H:HIS10 2.9 27.9 1.0
CE1 L:HIS10 2.9 30.2 1.0
CE1 H:HIS10 2.9 30.0 1.0
CD2 D:HIS10 2.9 24.8 1.0
CE1 D:HIS10 3.1 26.4 1.0
CD2 L:HIS10 3.2 28.9 1.0
ND1 H:HIS10 4.0 29.2 1.0
CG H:HIS10 4.0 26.3 1.0
ND1 L:HIS10 4.1 29.4 1.0
CG D:HIS10 4.1 23.5 1.0
ND1 D:HIS10 4.2 24.4 1.0
CG L:HIS10 4.3 30.3 1.0
CB L:LEU6 4.7 25.8 1.0
O D:LEU6 4.9 28.5 1.0
O L:LEU6 4.9 28.1 1.0
O H:LEU6 5.0 26.1 1.0
CG D:LEU6 5.0 30.4 1.0
CB D:LEU6 5.0 24.0 1.0

Reference:

E.Antolikova, L.Zakova, J.P.Turkenburg, C.J.Watson, I.Hanclova, M.Sanda, A.Cooper, T.Kraus, A.M.Brzozowski, J.A.Jiracek. Non-Equivalent Role of Inter- and Intramolecular Hydrogen Bonds in the Insulin Dimer Interface. J.Biol.Chem. V. 286 36968 2011.
ISSN: ISSN 0021-9258
PubMed: 21880708
DOI: 10.1074/JBC.M111.265249
Page generated: Wed Dec 16 04:59:46 2020

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