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Atomistry » Zinc » PDB 3tts-3u6m » 3tyl » |
Zinc in PDB 3tyl: Structure of Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(((3S,4S)-4-(2-((2-Fluorobenzyl)Amino)Ethoxy)Pyrrolidin-3-Yl) Methyl)-4-Methylpyridin-2-AmineEnzymatic activity of Structure of Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(((3S,4S)-4-(2-((2-Fluorobenzyl)Amino)Ethoxy)Pyrrolidin-3-Yl) Methyl)-4-Methylpyridin-2-Amine
All present enzymatic activity of Structure of Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(((3S,4S)-4-(2-((2-Fluorobenzyl)Amino)Ethoxy)Pyrrolidin-3-Yl) Methyl)-4-Methylpyridin-2-Amine:
1.14.13.39; Protein crystallography data
The structure of Structure of Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(((3S,4S)-4-(2-((2-Fluorobenzyl)Amino)Ethoxy)Pyrrolidin-3-Yl) Methyl)-4-Methylpyridin-2-Amine, PDB code: 3tyl
was solved by
H.Li,
T.L.Poulos,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 3tyl:
The structure of Structure of Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(((3S,4S)-4-(2-((2-Fluorobenzyl)Amino)Ethoxy)Pyrrolidin-3-Yl) Methyl)-4-Methylpyridin-2-Amine also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Structure of Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(((3S,4S)-4-(2-((2-Fluorobenzyl)Amino)Ethoxy)Pyrrolidin-3-Yl) Methyl)-4-Methylpyridin-2-Amine
(pdb code 3tyl). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Structure of Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(((3S,4S)-4-(2-((2-Fluorobenzyl)Amino)Ethoxy)Pyrrolidin-3-Yl) Methyl)-4-Methylpyridin-2-Amine, PDB code: 3tyl: Zinc binding site 1 out of 1 in 3tylGo back to Zinc Binding Sites List in 3tyl
Zinc binding site 1 out
of 1 in the Structure of Neuronal Nitric Oxide Synthase Heme Domain in Complex with 6-(((3S,4S)-4-(2-((2-Fluorobenzyl)Amino)Ethoxy)Pyrrolidin-3-Yl) Methyl)-4-Methylpyridin-2-Amine
Mono view Stereo pair view
Reference:
K.J.Labby,
F.Xue,
J.M.Kraus,
H.Ji,
J.Mataka,
H.Li,
P.Martasek,
L.J.Roman,
T.L.Poulos,
R.B.Silverman.
Intramolecular Hydrogen Bonding: A Potential Strategy For More Bioavailable Inhibitors of Neuronal Nitric Oxide Synthase. Bioorg.Med.Chem. V. 20 2435 2012.
Page generated: Sat Oct 26 16:49:57 2024
ISSN: ISSN 0968-0896 PubMed: 22370337 DOI: 10.1016/J.BMC.2012.01.037 |
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