Zinc in PDB 3rov: Insulin'S Biosynthesis and Activity Have Opposing Structural Requirements: A New Factor in Neonatal Diabetes Mellitus

The structure of Insulin'S Biosynthesis and Activity Have Opposing Structural Requirements: A New Factor in Neonatal Diabetes Mellitus, PDB code: 3rov was solved by M.A.Weiss, Z.L.Wan, E.J.Dodson, M.Liu, B.Xu, Q.X.Hua, M.Turkenburg, J.Whittingham, S.H.Nakagawa, K.Huang, S.Q.Hu, W.H.Jia, S.H.Wang, J.Brange, J.Whittaker, P.Arvan, P.G.Katsoyannis, G.G.Dodson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	44.36 / 2.30
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	45.662, 61.772, 46.038, 90.00, 105.50, 90.00
R / Rfree (%)	21.8 / 30.7

The structure of Insulin'S Biosynthesis and Activity Have Opposing Structural Requirements: A New Factor in Neonatal Diabetes Mellitus also contains other interesting chemical elements:

Chlorine

(Cl)

2 atoms

The binding sites of Zinc atom in the Insulin'S Biosynthesis and Activity Have Opposing Structural Requirements: A New Factor in Neonatal Diabetes Mellitus (pdb code 3rov). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Insulin'S Biosynthesis and Activity Have Opposing Structural Requirements: A New Factor in Neonatal Diabetes Mellitus, PDB code: 3rov:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Insulin'S Biosynthesis and Activity Have Opposing Structural Requirements: A New Factor in Neonatal Diabetes Mellitus


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Insulin'S Biosynthesis and Activity Have Opposing Structural Requirements: A New Factor in Neonatal Diabetes Mellitus within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn31 b:23.7 occ:1.00 NE2 B:HIS10 2.1 25.6 1.0 NE2 J:HIS10 2.1 21.8 1.0 NE2 F:HIS10 2.1 21.2 1.0 CL B:CL32 2.4 22.6 1.0 CD2 J:HIS10 3.0 21.9 1.0 CD2 F:HIS10 3.0 19.8 1.0 CE1 B:HIS10 3.0 24.0 1.0 CD2 B:HIS10 3.0 24.1 1.0 CE1 J:HIS10 3.1 20.9 1.0 CE1 F:HIS10 3.1 21.8 1.0 ND1 B:HIS10 4.1 26.5 1.0 CG J:HIS10 4.1 20.9 1.0 CG F:HIS10 4.2 21.7 1.0 CG B:HIS10 4.2 22.5 1.0 ND1 J:HIS10 4.2 20.8 1.0 ND1 F:HIS10 4.2 23.1 1.0 O B:LEU6 4.6 20.4 1.0 O F:LEU6 4.7 24.6 1.0 CB F:LEU6 4.7 20.3 1.0 CB B:LEU6 4.8 20.8 1.0 O J:LEU6 5.0 21.9 1.0

Zinc binding site 2 out of 2 in the Insulin'S Biosynthesis and Activity Have Opposing Structural Requirements: A New Factor in Neonatal Diabetes Mellitus


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Insulin'S Biosynthesis and Activity Have Opposing Structural Requirements: A New Factor in Neonatal Diabetes Mellitus within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn31 b:25.8 occ:1.00 NE2 D:HIS10 2.0 16.4 1.0 NE2 L:HIS10 2.1 13.1 1.0 NE2 H:HIS10 2.1 23.6 1.0 CL H:CL31 2.5 23.4 1.0 CD2 D:HIS10 2.9 13.6 1.0 CE1 H:HIS10 2.9 22.4 1.0 CD2 L:HIS10 3.0 17.9 1.0 CE1 L:HIS10 3.1 15.0 1.0 CE1 D:HIS10 3.2 15.0 1.0 CD2 H:HIS10 3.2 24.6 1.0 CG D:HIS10 4.1 17.2 1.0 CG L:HIS10 4.1 20.2 1.0 ND1 H:HIS10 4.1 23.4 1.0 ND1 L:HIS10 4.1 21.4 1.0 ND1 D:HIS10 4.2 11.0 1.0 CG H:HIS10 4.3 25.6 1.0 O H:LEU6 4.5 25.0 1.0 O D:LEU6 4.7 28.4 1.0 O L:LEU6 4.7 18.0 1.0 OG L:SER9 4.7 24.1 1.0 CB H:LEU6 4.8 17.9 1.0 CG D:LEU6 4.8 40.8 1.0 CB L:LEU6 4.8 16.9 1.0 O H:HOH34 5.0 48.6 1.0 CB D:LEU6 5.0 36.1 1.0

M.A.Weiss, Z.L.Wan, E.J.Dodson, M.Liu, B.Xu, Q.X.Hua, M.Turkenburg, J.Whittingham, S.H.Nakagawa, K.Huang, S.Q.Hu, W.H.Jia, S.H.Wang, J.Brange, J.Whittaker, P.Arvan, P.G.Katsoyannis, G.G.Dodson. Insulin'S Biosynthesis and Activity Have Opposing Structural Requirements: A New Factor in Neonatal Diabetes Mellitus To Be Published.