Zinc in PDB 3rc6: Molecular Mechanisms of Viral and Host-Cell Substrate Recognition By Hcv NS3/4A Protease

The structure of Molecular Mechanisms of Viral and Host-Cell Substrate Recognition By Hcv NS3/4A Protease, PDB code: 3rc6 was solved by C.A.Schiffer, K.P.Romano, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	26.62 / 1.30
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	54.850, 58.581, 60.901, 90.00, 90.00, 90.00
R / Rfree (%)	16.1 / 19.1

The binding sites of Zinc atom in the Molecular Mechanisms of Viral and Host-Cell Substrate Recognition By Hcv NS3/4A Protease (pdb code 3rc6). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Molecular Mechanisms of Viral and Host-Cell Substrate Recognition By Hcv NS3/4A Protease, PDB code: 3rc6:

Zinc binding site 1 out of 1 in the Molecular Mechanisms of Viral and Host-Cell Substrate Recognition By Hcv NS3/4A Protease


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Molecular Mechanisms of Viral and Host-Cell Substrate Recognition By Hcv NS3/4A Protease within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1 b:22.1 occ:1.00 O A:HOH160 2.1 7.7 1.0 SG A:CYS1145 2.2 11.9 1.0 SG A:CYS1099 2.3 11.3 0.5 SG A:CYS1097 2.3 10.2 1.0 SG A:CYS1099 2.5 6.8 0.5 ND1 A:HIS1149 2.9 17.2 1.0 CB A:CYS1145 3.1 9.5 1.0 CB A:CYS1099 3.1 10.4 0.5 CB A:CYS1099 3.3 9.6 0.5 CB A:CYS1097 3.4 9.4 1.0 N A:CYS1099 3.7 9.7 1.0 CG A:HIS1149 3.8 15.2 1.0 CE1 A:HIS1149 3.8 18.5 1.0 CA A:CYS1097 3.9 9.5 1.0 CB A:HIS1149 3.9 11.0 1.0 CA A:CYS1099 4.0 10.2 0.5 CA A:CYS1099 4.1 9.6 0.5 N A:THR1098 4.1 10.0 1.0 C A:CYS1097 4.4 9.4 1.0 CA A:CYS1145 4.6 9.3 1.0 CB A:ALA1147 4.7 10.8 1.0 C A:THR1098 4.8 10.0 1.0 O A:HOH68 4.8 21.1 1.0 NE2 A:HIS1149 4.9 18.7 1.0 CD2 A:HIS1149 4.9 17.4 1.0 C A:CYS1099 5.0 10.0 1.0

K.P.Romano, J.M.Laine, L.M.Deveau, H.Cao, F.Massi, C.A.Schiffer. Molecular Mechanisms of Viral and Host-Cell Substrate Recognition By Hcv NS3/4A Protease. J.Virol. 2011.
ISSN: ESSN 1098-5514
PubMed: 21507982
DOI: 10.1128/JVI.00377-11