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Zinc in PDB 3p7l: Rat Insulin Degrading Enzyme (Insulysin)

Enzymatic activity of Rat Insulin Degrading Enzyme (Insulysin)

All present enzymatic activity of Rat Insulin Degrading Enzyme (Insulysin):
3.4.24.56;

Protein crystallography data

The structure of Rat Insulin Degrading Enzyme (Insulysin), PDB code: 3p7l was solved by D.W.Rodgers, N.Noinaj, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 41.97 / 2.08
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 115.610, 70.980, 114.000, 90.00, 92.66, 90.00
R / Rfree (%) 20.2 / 26.9

Zinc Binding Sites:

The binding sites of Zinc atom in the Rat Insulin Degrading Enzyme (Insulysin) (pdb code 3p7l). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Rat Insulin Degrading Enzyme (Insulysin), PDB code: 3p7l:

Zinc binding site 1 out of 1 in 3p7l

Go back to Zinc Binding Sites List in 3p7l
Zinc binding site 1 out of 1 in the Rat Insulin Degrading Enzyme (Insulysin)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Rat Insulin Degrading Enzyme (Insulysin) within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1100

b:61.2
occ:1.00
OE1 A:GLU189 2.3 40.6 1.0
NE2 A:HIS112 2.3 43.3 1.0
NE2 A:HIS108 2.4 38.2 1.0
OE2 A:GLU189 2.9 44.3 1.0
CE1 A:HIS108 2.9 36.0 1.0
CD A:GLU189 2.9 43.7 1.0
CD2 A:HIS112 3.2 38.9 1.0
CE1 A:HIS112 3.3 40.9 1.0
CD2 A:HIS108 3.6 35.4 1.0
O A:HOH1206 4.1 44.9 1.0
ND1 A:HIS108 4.1 33.4 1.0
OE2 A:GLU111 4.2 37.2 1.0
OH A:TYR831 4.3 52.7 1.0
CE1 A:TYR831 4.3 43.3 1.0
CG A:GLU189 4.4 36.2 1.0
CG A:HIS112 4.4 37.4 1.0
ND1 A:HIS112 4.4 41.6 1.0
CG A:HIS108 4.5 32.0 1.0
CZ A:TYR831 4.8 44.9 1.0
CD A:GLU111 4.9 33.3 1.0
CB A:GLU189 4.9 36.9 1.0
OE1 A:GLU111 4.9 35.1 1.0

Reference:

N.Noinaj, S.K.Bhasin, E.S.Song, K.E.Scoggin, M.A.Juliano, L.Juliano, L.B.Hersh, D.W.Rodgers. Identification of the Allosteric Regulatory Site of Insulysin. Plos One V. 6 20864 2011.
ISSN: ESSN 1932-6203
PubMed: 21731629
DOI: 10.1371/JOURNAL.PONE.0020864
Page generated: Wed Dec 16 04:42:34 2020

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