Zinc in PDB 3p33: Insulin Fibrillation Is the Janus Face of Induced Fit. A Chiral Clamp Stabilizes the Native State at the Expense of Activity

The structure of Insulin Fibrillation Is the Janus Face of Induced Fit. A Chiral Clamp Stabilizes the Native State at the Expense of Activity, PDB code: 3p33 was solved by Q.X.Hua, Z.L.Wan, K.Huang, S.Q.Hu, N.F.Phillip, W.H.Jia, J.Whittingham, G.G.Dodson, P.G.Katsoyannis, M.A.Weiss, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	51.11 / 2.30
Space group	H 3
Cell size a, b, c (Å), α, β, γ (°)	77.900, 77.900, 78.300, 90.00, 90.00, 120.00
R / Rfree (%)	21.4 / 29.9

The structure of Insulin Fibrillation Is the Janus Face of Induced Fit. A Chiral Clamp Stabilizes the Native State at the Expense of Activity also contains other interesting chemical elements:

Chlorine

(Cl)

4 atoms

The binding sites of Zinc atom in the Insulin Fibrillation Is the Janus Face of Induced Fit. A Chiral Clamp Stabilizes the Native State at the Expense of Activity (pdb code 3p33). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Insulin Fibrillation Is the Janus Face of Induced Fit. A Chiral Clamp Stabilizes the Native State at the Expense of Activity, PDB code: 3p33:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Insulin Fibrillation Is the Janus Face of Induced Fit. A Chiral Clamp Stabilizes the Native State at the Expense of Activity


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Insulin Fibrillation Is the Janus Face of Induced Fit. A Chiral Clamp Stabilizes the Native State at the Expense of Activity within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn31 b:2.9 occ:0.33 NE2 B:HIS10 2.1 29.3 1.0 CL B:CL32 2.2 3.5 0.3 CE1 B:HIS10 2.9 28.0 1.0 CD2 B:HIS10 3.2 28.0 1.0 ND1 B:HIS10 4.1 32.8 1.0 CG B:HIS10 4.2 28.2 1.0 O B:LEU6 4.7 25.1 1.0

Zinc binding site 2 out of 4 in the Insulin Fibrillation Is the Janus Face of Induced Fit. A Chiral Clamp Stabilizes the Native State at the Expense of Activity


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Insulin Fibrillation Is the Janus Face of Induced Fit. A Chiral Clamp Stabilizes the Native State at the Expense of Activity within 5.0Å range: probe atom residue distance (Å) B Occ D:Zn31 b:6.8 occ:0.33 NE2 D:HIS10 2.1 29.4 1.0 CL D:CL32 2.3 5.2 0.3 CE1 D:HIS10 2.7 29.1 1.0 CD2 D:HIS10 3.3 30.3 1.0 ND1 D:HIS10 3.9 31.2 1.0 CG D:HIS10 4.3 25.4 1.0 O D:LEU6 4.8 34.5 1.0

Zinc binding site 3 out of 4 in the Insulin Fibrillation Is the Janus Face of Induced Fit. A Chiral Clamp Stabilizes the Native State at the Expense of Activity


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Insulin Fibrillation Is the Janus Face of Induced Fit. A Chiral Clamp Stabilizes the Native State at the Expense of Activity within 5.0Å range: probe atom residue distance (Å) B Occ F:Zn31 b:5.4 occ:0.33 NE2 F:HIS10 2.0 38.4 1.0 CL F:CL32 2.3 36.2 0.3 CD2 F:HIS10 2.8 34.7 1.0 CE1 F:HIS10 3.1 36.2 1.0 CG F:HIS10 4.0 30.1 1.0 ND1 F:HIS10 4.1 33.6 1.0 O F:HOH47 4.5 62.9 1.0 O F:LEU6 4.7 39.0 1.0

Zinc binding site 4 out of 4 in the Insulin Fibrillation Is the Janus Face of Induced Fit. A Chiral Clamp Stabilizes the Native State at the Expense of Activity


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Insulin Fibrillation Is the Janus Face of Induced Fit. A Chiral Clamp Stabilizes the Native State at the Expense of Activity within 5.0Å range: probe atom residue distance (Å) B Occ H:Zn31 b:6.5 occ:0.33 NE2 H:HIS10 2.0 31.1 1.0 CL H:CL32 2.3 10.6 0.3 CE1 H:HIS10 2.9 35.3 1.0 CD2 H:HIS10 3.1 31.2 1.0 ND1 H:HIS10 4.1 34.7 1.0 CG H:HIS10 4.2 32.6 1.0 O H:LEU6 4.7 30.1 1.0

Q.X.Hua, Z.L.Wan, K.Huang, S.Q.Hu, N.F.Phillip, W.H.Jia, J.Whittingham, G.G.Dodson, P.G.Katsoyannis, M.A.Weiss. Insulin Fibrillation Is the Janus Face of Induced Fit. A Chiral Clamp Stabilizes the Native State at the Expense of Activity To Be Published.