Atomistry » Zinc » PDB 3oxf-3p3h » 3oyq
Atomistry »
  Zinc »
    PDB 3oxf-3p3h »
      3oyq »

Zinc in PDB 3oyq: Structure of Human Carbonic Anhydrase II Complexed with 5,6-Dihydro- Benzo[H]Cinnolin-3-Ylamine

Enzymatic activity of Structure of Human Carbonic Anhydrase II Complexed with 5,6-Dihydro- Benzo[H]Cinnolin-3-Ylamine

All present enzymatic activity of Structure of Human Carbonic Anhydrase II Complexed with 5,6-Dihydro- Benzo[H]Cinnolin-3-Ylamine:
4.2.1.1;

Protein crystallography data

The structure of Structure of Human Carbonic Anhydrase II Complexed with 5,6-Dihydro- Benzo[H]Cinnolin-3-Ylamine, PDB code: 3oyq was solved by M.Aggarwal, R.Mckenna, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 23.26 / 1.47
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 42.266, 41.351, 71.963, 90.00, 104.19, 90.00
R / Rfree (%) 16.6 / 18.2

Zinc Binding Sites:

The binding sites of Zinc atom in the Structure of Human Carbonic Anhydrase II Complexed with 5,6-Dihydro- Benzo[H]Cinnolin-3-Ylamine (pdb code 3oyq). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Structure of Human Carbonic Anhydrase II Complexed with 5,6-Dihydro- Benzo[H]Cinnolin-3-Ylamine, PDB code: 3oyq:

Zinc binding site 1 out of 1 in 3oyq

Go back to Zinc Binding Sites List in 3oyq
Zinc binding site 1 out of 1 in the Structure of Human Carbonic Anhydrase II Complexed with 5,6-Dihydro- Benzo[H]Cinnolin-3-Ylamine


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Human Carbonic Anhydrase II Complexed with 5,6-Dihydro- Benzo[H]Cinnolin-3-Ylamine within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn262

b:10.4
occ:1.00
 NAC A:OYQ263 1.9 5.3 0.8
NE2 A:HIS94 2.0 9.2 1.0
NE2 A:HIS96 2.0 9.5 1.0
ND1 A:HIS119 2.0 10.3 1.0
CE1 A:HIS119 2.9 7.8 1.0
CD2 A:HIS94 3.0 9.5 1.0
SAS A:OYQ263 3.0 15.5 0.8
CD2 A:HIS96 3.0 10.0 1.0
CE1 A:HIS96 3.0 11.2 1.0
OAF A:OYQ263 3.1 14.5 0.8
CE1 A:HIS94 3.1 8.4 1.0
CG A:HIS119 3.1 8.1 1.0
CB A:HIS119 3.6 8.2 1.0
OG1 A:THR199 3.8 9.1 1.0
OE1 A:GLU106 4.0 10.2 1.0
NE2 A:HIS119 4.1 8.6 1.0
CG A:HIS94 4.1 8.8 1.0
ND1 A:HIS94 4.1 9.5 1.0
ND1 A:HIS96 4.1 10.5 1.0
OAE A:OYQ263 4.2 12.2 0.8
CG A:HIS96 4.2 10.3 1.0
CAQ A:OYQ263 4.2 17.2 0.8
CD2 A:HIS119 4.2 7.6 1.0
C3 A:GOL400 4.3 13.4 1.0
CAJ A:OYQ263 4.8 13.7 0.8
CD A:GLU106 4.9 11.4 1.0
C2 A:GOL400 4.9 22.8 1.0

Reference:

N.Hen, M.Bialer, B.Yagen, A.Maresca, M.Aggarwal, A.H.Robbins, R.Mckenna, A.Scozzafava, C.T.Supuran. Anticonvulsant 4-Aminobenzenesulfonamide Derivatives with Branched-Alkylamide Moieties: X-Ray Crystallography and Inhibition Studies of Human Carbonic Anhydrase Isoforms I, II, VII, and Xiv. J.Med.Chem. V. 54 3977 2011.
ISSN: ISSN 0022-2623
PubMed: 21506569
DOI: 10.1021/JM200209N
Page generated: Sat Oct 26 11:13:40 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy