Zinc in PDB 3oyk: Crystal Structure of the Pfv S217H Mutant Intasome Bound to Manganese

The structure of Crystal Structure of the Pfv S217H Mutant Intasome Bound to Manganese, PDB code: 3oyk was solved by S.Hare, P.Cherepanov, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	39.15 / 2.72
Space group	P 41 21 2
Cell size a, b, c (Å), α, β, γ (°)	159.790, 159.790, 123.870, 90.00, 90.00, 90.00
R / Rfree (%)	20.2 / 23.3

The structure of Crystal Structure of the Pfv S217H Mutant Intasome Bound to Manganese also contains other interesting chemical elements:

Manganese

(Mn)

2 atoms

The binding sites of Zinc atom in the Crystal Structure of the Pfv S217H Mutant Intasome Bound to Manganese (pdb code 3oyk). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of the Pfv S217H Mutant Intasome Bound to Manganese, PDB code: 3oyk:

Zinc binding site 1 out of 1 in the Crystal Structure of the Pfv S217H Mutant Intasome Bound to Manganese


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of the Pfv S217H Mutant Intasome Bound to Manganese within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn393 b:48.4 occ:1.00 NE2 A:HIS62 1.9 47.3 1.0 ND1 A:HIS66 2.0 43.0 1.0 SG A:CYS99 2.2 45.6 1.0 SG A:CYS96 2.2 52.4 1.0 CE1 A:HIS62 2.9 47.4 1.0 CE1 A:HIS66 2.9 43.3 1.0 CD2 A:HIS62 3.0 47.2 1.0 CG A:HIS66 3.1 43.3 1.0 CB A:CYS96 3.3 52.9 1.0 CB A:CYS99 3.3 45.1 1.0 CB A:HIS66 3.5 43.4 1.0 N A:CYS99 3.8 46.8 1.0 CA A:HIS66 3.9 43.8 1.0 ND1 A:HIS62 4.0 47.0 1.0 CA A:CYS99 4.0 45.5 1.0 NE2 A:HIS66 4.1 43.8 1.0 CG A:HIS62 4.1 47.7 1.0 CD2 A:HIS66 4.2 43.3 1.0 C A:HIS66 4.5 44.1 1.0 O A:HIS66 4.5 44.3 1.0 CA A:CYS96 4.7 53.0 1.0 C A:GLN98 4.8 48.1 1.0 OD1 A:ASN63 4.8 52.6 1.0 CB A:GLN98 4.8 49.4 1.0

S.Hare, A.M.Vos, R.F.Clayton, J.W.Thuring, M.D.Cummings, P.Cherepanov. Molecular Mechanisms of Retroviral Integrase Inhibition and the Evolution of Viral Resistance. Proc.Natl.Acad.Sci.Usa V. 107 20057 2010.
ISSN: ISSN 0027-8424
PubMed: 21030679
DOI: 10.1073/PNAS.1010246107