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Zinc in PDB 3ly2: Catalytic Domain of Human Phosphodiesterase 4B in Complex with A Coumarin-Based Inhibitor
Enzymatic activity of Catalytic Domain of Human Phosphodiesterase 4B in Complex with A Coumarin-Based Inhibitor
All present enzymatic activity of Catalytic Domain of Human Phosphodiesterase 4B in Complex with A Coumarin-Based Inhibitor:
3.1.4.17;
3.1.4.17;
Protein crystallography data
The structure of Catalytic Domain of Human Phosphodiesterase 4B in Complex with A Coumarin-Based Inhibitor, PDB code: 3ly2
was solved by
A.K.Shiau,
A.R.Coyle,
J.H.Hsien,
L.M.Staszewski,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 49.84 / 2.60 |
| Space group | C 2 2 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 214.796, 233.964, 165.258, 90.00, 90.00, 90.00 |
| R / Rfree (%) | n/a / n/a |
Other elements in 3ly2:
The structure of Catalytic Domain of Human Phosphodiesterase 4B in Complex with A Coumarin-Based Inhibitor also contains other interesting chemical elements:
| Magnesium | (Mg) | 8 atoms |
| Chlorine | (Cl) | 16 atoms |
Zinc Binding Sites:
The binding sites of Zinc atom in the Catalytic Domain of Human Phosphodiesterase 4B in Complex with A Coumarin-Based Inhibitor
(pdb code 3ly2). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 8 binding sites of Zinc where determined in the Catalytic Domain of Human Phosphodiesterase 4B in Complex with A Coumarin-Based Inhibitor, PDB code: 3ly2:
Jump to Zinc binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
In total 8 binding sites of Zinc where determined in the Catalytic Domain of Human Phosphodiesterase 4B in Complex with A Coumarin-Based Inhibitor, PDB code: 3ly2:
Jump to Zinc binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
Zinc binding site 1 out of 8 in 3ly2
Go back to
Zinc Binding Sites List in 3ly2
Zinc binding site 1 out
of 8 in the Catalytic Domain of Human Phosphodiesterase 4B in Complex with A Coumarin-Based Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of Catalytic Domain of Human Phosphodiesterase 4B in Complex with A Coumarin-Based Inhibitor within 5.0Å range:
|
Zinc binding site 2 out of 8 in 3ly2
Go back to
Zinc Binding Sites List in 3ly2
Zinc binding site 2 out
of 8 in the Catalytic Domain of Human Phosphodiesterase 4B in Complex with A Coumarin-Based Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 2 of Catalytic Domain of Human Phosphodiesterase 4B in Complex with A Coumarin-Based Inhibitor within 5.0Å range:
|
Zinc binding site 3 out of 8 in 3ly2
Go back to
Zinc Binding Sites List in 3ly2
Zinc binding site 3 out
of 8 in the Catalytic Domain of Human Phosphodiesterase 4B in Complex with A Coumarin-Based Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 3 of Catalytic Domain of Human Phosphodiesterase 4B in Complex with A Coumarin-Based Inhibitor within 5.0Å range:
|
Zinc binding site 4 out of 8 in 3ly2
Go back to
Zinc Binding Sites List in 3ly2
Zinc binding site 4 out
of 8 in the Catalytic Domain of Human Phosphodiesterase 4B in Complex with A Coumarin-Based Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 4 of Catalytic Domain of Human Phosphodiesterase 4B in Complex with A Coumarin-Based Inhibitor within 5.0Å range:
|
Zinc binding site 5 out of 8 in 3ly2
Go back to
Zinc Binding Sites List in 3ly2
Zinc binding site 5 out
of 8 in the Catalytic Domain of Human Phosphodiesterase 4B in Complex with A Coumarin-Based Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 5 of Catalytic Domain of Human Phosphodiesterase 4B in Complex with A Coumarin-Based Inhibitor within 5.0Å range:
|
Zinc binding site 6 out of 8 in 3ly2
Go back to
Zinc Binding Sites List in 3ly2
Zinc binding site 6 out
of 8 in the Catalytic Domain of Human Phosphodiesterase 4B in Complex with A Coumarin-Based Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 6 of Catalytic Domain of Human Phosphodiesterase 4B in Complex with A Coumarin-Based Inhibitor within 5.0Å range:
|
Zinc binding site 7 out of 8 in 3ly2
Go back to
Zinc Binding Sites List in 3ly2
Zinc binding site 7 out
of 8 in the Catalytic Domain of Human Phosphodiesterase 4B in Complex with A Coumarin-Based Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 7 of Catalytic Domain of Human Phosphodiesterase 4B in Complex with A Coumarin-Based Inhibitor within 5.0Å range:
|
Zinc binding site 8 out of 8 in 3ly2
Go back to
Zinc Binding Sites List in 3ly2
Zinc binding site 8 out
of 8 in the Catalytic Domain of Human Phosphodiesterase 4B in Complex with A Coumarin-Based Inhibitor
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 8 of Catalytic Domain of Human Phosphodiesterase 4B in Complex with A Coumarin-Based Inhibitor within 5.0Å range:
|
Reference:
S.P.Govek,
G.Oshiro,
J.V.Anzola,
C.Beauregard,
J.Chen,
A.R.Coyle,
D.A.Gamache,
M.R.Hellberg,
J.N.Hsien,
J.M.Lerch,
J.C.Liao,
J.W.Malecha,
L.M.Staszewski,
D.J.Thomas,
J.M.Yanni,
S.A.Noble,
A.K.Shiau.
Water-Soluble PDE4 Inhibitors For the Treatment of Dry Eye. Bioorg.Med.Chem.Lett. V. 20 2928 2010.
ISSN: ISSN 0960-894X
PubMed: 20378348
DOI: 10.1016/J.BMCL.2010.03.023
Page generated: Sat Oct 26 08:58:15 2024
ISSN: ISSN 0960-894X
PubMed: 20378348
DOI: 10.1016/J.BMCL.2010.03.023
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