Zinc in PDB 3lsx: Piracetam Bound to the Ligand Binding Domain of GLUA3

The structure of Piracetam Bound to the Ligand Binding Domain of GLUA3, PDB code: 3lsx was solved by A.H.Ahmed, R.E.Oswald, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	45.04 / 2.01
Space group	P 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	47.364, 47.655, 137.981, 90.00, 90.00, 90.00
R / Rfree (%)	16.8 / 22.2

The binding sites of Zinc atom in the Piracetam Bound to the Ligand Binding Domain of GLUA3 (pdb code 3lsx). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Piracetam Bound to the Ligand Binding Domain of GLUA3, PDB code: 3lsx:

Zinc binding site 1 out of 1 in the Piracetam Bound to the Ligand Binding Domain of GLUA3


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Piracetam Bound to the Ligand Binding Domain of GLUA3 within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn262 b:32.6 occ:1.00 O A:HOH292 2.1 29.7 1.0 OE2 A:GLU24 2.2 35.9 1.0 O A:HOH314 2.2 33.1 1.0 OE1 A:GLU24 2.5 28.9 1.0 CD A:GLU24 2.6 28.9 1.0 CG A:GLU24 4.0 29.0 1.0 O A:HOH294 4.6 29.4 1.0

A.H.Ahmed, R.E.Oswald. Piracetam Defines A New Binding Site For Allosteric Modulators of Alpha-Amino-3-Hydroxy-5-Methyl-4-Isoxazole-Propionic Acid (Ampa) Receptors. J.Med.Chem. V. 53 2197 2010.
ISSN: ISSN 0022-2623
PubMed: 20163115
DOI: 10.1021/JM901905J