Zinc in PDB 3k1l: Crystal Structure of Fancl

All present enzymatic activity of Crystal Structure of Fancl:
6.3.2.19;

The structure of Crystal Structure of Fancl, PDB code: 3k1l was solved by A.R.Cole, H.Walden, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	77.93 / 3.20
Space group	H 3 2
Cell size a, b, c (Å), α, β, γ (°)	188.680, 188.680, 259.360, 90.00, 90.00, 120.00
R / Rfree (%)	20.5 / 24.7

The structure of Crystal Structure of Fancl also contains other interesting chemical elements:

Gold

(Au)

13 atoms

The binding sites of Zinc atom in the Crystal Structure of Fancl (pdb code 3k1l). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Crystal Structure of Fancl, PDB code: 3k1l:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Crystal Structure of Fancl


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Fancl within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn382 b:0.7 occ:1.00 SG B:CYS364 2.0 74.7 1.0 SG B:CYS367 2.3 0.6 1.0 SG B:CYS334 2.3 89.1 1.0 SG B:CYS329 2.5 86.9 1.0 CB B:CYS334 2.8 99.1 1.0 CB B:CYS367 3.0 0.2 1.0 CB B:CYS364 3.1 79.2 1.0 N B:CYS367 3.2 91.8 1.0 CA B:CYS367 3.6 0.5 1.0 CB B:CYS329 4.0 82.9 1.0 CB B:PHE366 4.0 0.3 1.0 C B:PHE366 4.1 0.7 1.0 CA B:CYS334 4.3 0.3 1.0 C B:CYS367 4.4 0.9 1.0 CA B:PHE366 4.5 93.3 1.0 N B:LYS368 4.5 84.6 1.0 CA B:CYS364 4.5 0.0 1.0 CB B:ASN331 4.5 81.5 1.0 N B:PHE366 4.6 95.6 1.0 CB B:ALA369 4.6 0.6 1.0 ND2 B:ASN331 4.7 89.0 1.0 N B:ALA369 4.7 79.3 1.0 C B:CYS364 4.9 0.3 1.0 O B:CYS364 4.9 0.1 1.0 CG B:ASN331 5.0 81.3 1.0 O B:CYS334 5.0 99.3 1.0

Zinc binding site 2 out of 4 in the Crystal Structure of Fancl


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Fancl within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn383 b:0.7 occ:1.00 ND1 B:HIS339 1.8 0.7 1.0 SG B:CYS342 2.0 63.0 1.0 SG B:CYS314 2.0 61.3 1.0 CG B:HIS339 2.4 0.1 1.0 SG B:CYS311 2.5 68.4 1.0 CB B:HIS339 2.5 0.0 1.0 CE1 B:HIS339 3.0 0.9 1.0 CB B:CYS342 3.3 62.2 1.0 CB B:CYS311 3.4 73.0 1.0 CD2 B:HIS339 3.7 0.1 1.0 CA B:HIS339 3.7 66.3 1.0 N B:HIS339 3.8 75.2 1.0 CB B:CYS314 3.8 61.9 1.0 NE2 B:HIS339 3.9 0.6 1.0 CD1 B:LEU319 4.1 64.8 1.0 CD2 B:LEU319 4.1 62.2 1.0 CG B:LEU319 4.4 62.0 1.0 CA B:CYS311 4.5 0.5 1.0 CA B:CYS342 4.5 70.6 1.0 N B:CYS342 4.6 68.4 1.0 C B:HIS339 4.6 66.3 1.0 O B:HIS339 4.7 68.3 1.0 N B:CYS314 4.7 92.1 1.0 CA B:CYS314 4.9 84.6 1.0

Zinc binding site 3 out of 4 in the Crystal Structure of Fancl


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Crystal Structure of Fancl within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn382 b:0.7 occ:1.00 SG A:CYS367 1.9 89.5 1.0 SG A:CYS364 2.0 64.9 1.0 SG A:CYS334 2.1 69.3 1.0 SG A:CYS329 2.2 74.7 1.0 CB A:CYS364 2.8 67.8 1.0 CB A:CYS367 3.0 84.2 1.0 N A:CYS367 3.3 69.0 1.0 CB A:CYS334 3.3 80.7 1.0 CB A:CYS329 3.5 68.5 1.0 CA A:CYS367 3.6 74.1 1.0 CB A:ASN331 4.1 0.2 1.0 C A:CYS367 4.1 71.8 1.0 CA A:CYS364 4.2 73.4 1.0 N A:LYS368 4.3 0.4 1.0 C A:PHE366 4.3 89.0 1.0 ND2 A:ASN331 4.4 0.4 1.0 N A:ALA369 4.5 0.0 1.0 CB A:PHE366 4.5 0.4 1.0 CB A:ALA369 4.6 72.2 1.0 CA A:CYS334 4.6 87.1 1.0 C A:CYS364 4.7 75.4 1.0 N A:PHE366 4.7 74.7 1.0 CG A:ASN331 4.7 0.2 1.0 CA A:PHE366 4.7 74.6 1.0 O A:CYS364 4.8 89.7 1.0 O A:CYS367 4.9 78.7 1.0 CA A:CYS329 4.9 78.3 1.0

Zinc binding site 4 out of 4 in the Crystal Structure of Fancl


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Crystal Structure of Fancl within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn383 b:0.7 occ:1.00 ND1 A:HIS339 1.7 88.9 1.0 SG A:CYS311 1.9 56.1 1.0 SG A:CYS314 2.2 55.4 1.0 CG A:HIS339 2.4 91.0 1.0 CB A:CYS311 2.6 61.1 1.0 SG A:CYS342 2.6 63.8 1.0 CB A:HIS339 2.7 91.4 1.0 CE1 A:HIS339 2.8 89.9 1.0 N A:HIS339 3.4 82.4 1.0 CA A:CYS311 3.5 0.7 1.0 CD2 A:HIS339 3.6 93.8 1.0 CA A:HIS339 3.6 74.8 1.0 NE2 A:HIS339 3.7 92.8 1.0 CB A:CYS342 3.8 68.3 1.0 CB A:CYS314 3.9 54.4 1.0 N A:CYS311 4.3 0.1 1.0 O A:ALA316 4.4 71.1 1.0 CD2 A:LEU319 4.5 56.0 1.0 N A:CYS314 4.6 98.2 1.0 C A:CYS338 4.6 74.4 1.0 C A:HIS339 4.7 74.2 1.0 CD1 A:LEU319 4.7 60.3 1.0 C A:CYS311 4.8 0.3 1.0 O A:HIS339 4.8 74.1 1.0 CA A:CYS314 4.8 91.4 1.0 CG A:LEU319 4.9 59.0 1.0 N A:ASN312 4.9 88.5 1.0

A.R.Cole, L.P.C.Lewis, H.Walden. The Structure of the Catalytic Subunit Fancl of the Fanconi Anemia Core Complex Nat.Struct.Mol.Biol. V. 17 294 2010.
ISSN: ISSN 1545-9993
PubMed: 20154706
DOI: 10.1038/NSMB.1759