Zinc in PDB 3iu6: Crystal Structure of the Sixth Bromodomain of Human Poly-Bromodomain Containing Protein 1 (PB1)

The structure of Crystal Structure of the Sixth Bromodomain of Human Poly-Bromodomain Containing Protein 1 (PB1), PDB code: 3iu6 was solved by P.Filippakopoulos, T.Keates, S.Picaud, A.C.W.Pike, E.Ugochukwu, F.Vondelft, C.H.Arrowsmith, A.M.Edwards, J.Weigelt, C.Bountra, S.Knapp, Structural Genomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	33.20 / 1.79
Space group	P 32 2 1
Cell size a, b, c (Å), α, β, γ (°)	66.400, 66.400, 85.430, 90.00, 90.00, 120.00
R / Rfree (%)	16.5 / 20.2

The binding sites of Zinc atom in the Crystal Structure of the Sixth Bromodomain of Human Poly-Bromodomain Containing Protein 1 (PB1) (pdb code 3iu6). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of the Sixth Bromodomain of Human Poly-Bromodomain Containing Protein 1 (PB1), PDB code: 3iu6:

Zinc binding site 1 out of 1 in the Crystal Structure of the Sixth Bromodomain of Human Poly-Bromodomain Containing Protein 1 (PB1)


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of the Sixth Bromodomain of Human Poly-Bromodomain Containing Protein 1 (PB1) within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn950 b:11.9 occ:0.50 OE2 A:GLU798 1.9 8.7 1.0 NE2 A:HIS751 2.1 2.4 1.0 CD A:GLU798 2.7 11.1 1.0 OE1 A:GLU798 2.9 8.8 1.0 CE1 A:HIS751 3.0 6.3 1.0 CD2 A:HIS751 3.1 2.2 1.0 ND1 A:HIS751 4.1 2.5 1.0 CG A:GLU798 4.2 7.8 1.0 CG A:HIS751 4.2 2.0 1.0 CG2 A:VAL755 4.5 2.0 1.0 O A:HOH85 4.6 20.3 1.0 O A:HOH115 4.9 32.2 1.0

P.Filippakopoulos, S.Picaud, M.Mangos, T.Keates, J.P.Lambert, D.Barsyte-Lovejoy, I.Felletar, R.Volkmer, S.Muller, T.Pawson, A.C.Gingras, C.H.Arrowsmith, S.Knapp. Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family. Cell(Cambridge,Mass.) V. 149 214 2012.
ISSN: ISSN 0092-8674
PubMed: 22464331
DOI: 10.1016/J.CELL.2012.02.013