Zinc in PDB 3iaz: Structural Basis of the Prevention of Nsaid-Induced Damage of the Gastrointestinal Tract By C-Terminal Half (C-Lobe) of Bovine Colostrum Protein Lactoferrin: Binding and Structural Studies of the C-Lobe Complex with Aspirin

The structure of Structural Basis of the Prevention of Nsaid-Induced Damage of the Gastrointestinal Tract By C-Terminal Half (C-Lobe) of Bovine Colostrum Protein Lactoferrin: Binding and Structural Studies of the C-Lobe Complex with Aspirin, PDB code: 3iaz was solved by R.Mir, N.Singh, M.Sinha, S.Sharma, P.Kaur, A.Srinivasan, T.P.Singh, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	63.25 / 2.00
Space group	P 1 21 1
Cell size a, b, c (Å), α, β, γ (°)	63.308, 50.469, 65.942, 90.00, 107.70, 90.00
R / Rfree (%)	18.2 / 22.8

The structure of Structural Basis of the Prevention of Nsaid-Induced Damage of the Gastrointestinal Tract By C-Terminal Half (C-Lobe) of Bovine Colostrum Protein Lactoferrin: Binding and Structural Studies of the C-Lobe Complex with Aspirin also contains other interesting chemical elements:

Iron

(Fe)

1 atom

The binding sites of Zinc atom in the Structural Basis of the Prevention of Nsaid-Induced Damage of the Gastrointestinal Tract By C-Terminal Half (C-Lobe) of Bovine Colostrum Protein Lactoferrin: Binding and Structural Studies of the C-Lobe Complex with Aspirin (pdb code 3iaz). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Structural Basis of the Prevention of Nsaid-Induced Damage of the Gastrointestinal Tract By C-Terminal Half (C-Lobe) of Bovine Colostrum Protein Lactoferrin: Binding and Structural Studies of the C-Lobe Complex with Aspirin, PDB code: 3iaz:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Structural Basis of the Prevention of Nsaid-Induced Damage of the Gastrointestinal Tract By C-Terminal Half (C-Lobe) of Bovine Colostrum Protein Lactoferrin: Binding and Structural Studies of the C-Lobe Complex with Aspirin


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structural Basis of the Prevention of Nsaid-Induced Damage of the Gastrointestinal Tract By C-Terminal Half (C-Lobe) of Bovine Colostrum Protein Lactoferrin: Binding and Structural Studies of the C-Lobe Complex with Aspirin within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn787 b:25.4 occ:1.00 O A:HOH272 1.9 28.3 1.0 OE2 A:GLU659 2.2 23.1 1.0 OE1 A:GLU659 2.4 17.3 1.0 CD A:GLU659 2.6 24.5 1.0 O A:GLY653 3.9 33.5 1.0 CG A:GLU659 4.1 23.3 1.0 O A:ARG654 4.5 27.4 1.0 O A:HOH285 4.7 50.9 1.0 CB A:GLU659 4.9 23.9 1.0

Zinc binding site 2 out of 2 in the Structural Basis of the Prevention of Nsaid-Induced Damage of the Gastrointestinal Tract By C-Terminal Half (C-Lobe) of Bovine Colostrum Protein Lactoferrin: Binding and Structural Studies of the C-Lobe Complex with Aspirin


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Structural Basis of the Prevention of Nsaid-Induced Damage of the Gastrointestinal Tract By C-Terminal Half (C-Lobe) of Bovine Colostrum Protein Lactoferrin: Binding and Structural Studies of the C-Lobe Complex with Aspirin within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn788 b:29.4 occ:1.00 O A:HOH246 1.8 32.1 1.0 O A:HOH50 2.0 34.6 1.0 NE2 A:HIS588 2.1 22.1 1.0 O A:HOH268 2.2 59.9 1.0 CE1 A:HIS588 3.0 22.9 1.0 CD2 A:HIS588 3.1 22.9 1.0 ND1 A:HIS588 4.1 23.4 1.0 CG A:HIS588 4.2 22.5 1.0 CG2 A:VAL591 4.3 27.3 1.0 O A:HOH287 4.3 60.2 1.0 O A:HOH78 4.6 29.2 1.0

R.Mir, N.Singh, G.Vikram, R.P.Kumar, M.Sinha, A.Bhushan, P.Kaur, A.Srinivasan, S.Sharma, T.P.Singh. The Structural Basis For the Prevention of Nonsteroidal Antiinflammatory Drug-Induced Gastrointestinal Tract Damage By the C-Lobe of Bovine Colostrum Lactoferrin Biophys.J. V. 97 3178 2009.
ISSN: ISSN 0006-3495
PubMed: 20006955
DOI: 10.1016/J.BPJ.2009.09.030