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Zinc in PDB 3h44: Crystal Structure of Insulin Degrading Enzyme in Complex with Macrophage Inflammatory Protein 1 Alpha

Enzymatic activity of Crystal Structure of Insulin Degrading Enzyme in Complex with Macrophage Inflammatory Protein 1 Alpha

All present enzymatic activity of Crystal Structure of Insulin Degrading Enzyme in Complex with Macrophage Inflammatory Protein 1 Alpha:
3.4.24.56;

Protein crystallography data

The structure of Crystal Structure of Insulin Degrading Enzyme in Complex with Macrophage Inflammatory Protein 1 Alpha, PDB code: 3h44 was solved by M.Ren, Q.Guo, W.J.Tang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 30.00 / 3.00
Space group P 65
Cell size a, b, c (Å), α, β, γ (°) 262.737, 262.737, 90.502, 90.00, 90.00, 120.00
R / Rfree (%) 18.3 / 23.7

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Insulin Degrading Enzyme in Complex with Macrophage Inflammatory Protein 1 Alpha (pdb code 3h44). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of Insulin Degrading Enzyme in Complex with Macrophage Inflammatory Protein 1 Alpha, PDB code: 3h44:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 3h44

Go back to Zinc Binding Sites List in 3h44
Zinc binding site 1 out of 2 in the Crystal Structure of Insulin Degrading Enzyme in Complex with Macrophage Inflammatory Protein 1 Alpha


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Insulin Degrading Enzyme in Complex with Macrophage Inflammatory Protein 1 Alpha within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn1

b:2.0
occ:1.00
OE1 B:GLU189 1.7 34.7 1.0
NE2 B:HIS108 1.8 38.0 1.0
O D:ARG19 1.9 90.2 1.0
NE2 B:HIS112 2.1 46.4 1.0
CD B:GLU189 2.5 44.0 1.0
OE2 B:GLU189 2.8 45.3 1.0
CE1 B:HIS108 2.8 39.8 1.0
C D:ARG19 2.8 90.7 1.0
CD2 B:HIS108 2.8 41.6 1.0
CD2 B:HIS112 3.0 48.1 1.0
CE1 B:HIS112 3.1 47.9 1.0
N D:ARG19 3.4 90.6 1.0
O D:SER18 3.5 90.6 1.0
CA D:ARG19 3.5 90.6 1.0
C D:SER18 3.5 90.4 1.0
OE1 B:GLN111 3.7 49.0 1.0
N D:GLN20 3.8 91.1 1.0
CB D:GLN20 3.9 91.0 1.0
ND1 B:HIS108 3.9 40.7 1.0
CG B:HIS108 4.0 41.6 1.0
CG B:GLU189 4.0 44.6 1.0
CA D:GLN20 4.1 91.4 1.0
CG B:HIS112 4.1 48.4 1.0
ND1 B:HIS112 4.2 47.4 1.0
CG D:GLN20 4.2 89.4 1.0
CD B:GLN111 4.5 48.1 1.0
CA D:SER18 4.5 89.8 1.0
NE2 B:GLN111 4.5 49.1 1.0
CB D:SER18 4.6 89.5 1.0
OH B:TYR831 4.7 56.7 1.0
CB D:ARG19 5.0 90.4 1.0

Zinc binding site 2 out of 2 in 3h44

Go back to Zinc Binding Sites List in 3h44
Zinc binding site 2 out of 2 in the Crystal Structure of Insulin Degrading Enzyme in Complex with Macrophage Inflammatory Protein 1 Alpha


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of Insulin Degrading Enzyme in Complex with Macrophage Inflammatory Protein 1 Alpha within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Zn42

b:2.0
occ:1.00
O C:ARG19 1.6 85.2 1.0
OE1 A:GLU189 1.7 12.4 1.0
NE2 A:HIS108 1.9 33.6 1.0
NE2 A:HIS112 2.0 41.5 1.0
CD A:GLU189 2.5 27.2 1.0
C C:ARG19 2.6 85.8 1.0
OE2 A:GLU189 2.7 29.3 1.0
CD2 A:HIS108 2.8 37.0 1.0
CD2 A:HIS112 3.0 42.0 1.0
CE1 A:HIS112 3.0 41.5 1.0
N C:ARG19 3.0 85.8 1.0
CE1 A:HIS108 3.0 36.4 1.0
CA C:ARG19 3.2 85.9 1.0
C C:SER18 3.6 85.5 1.0
N C:GLN20 3.9 86.4 1.0
O C:SER18 3.9 85.3 1.0
CG A:GLU189 4.0 33.3 1.0
CG A:HIS108 4.0 37.4 1.0
NE2 A:GLN111 4.0 35.9 1.0
OE1 A:GLN111 4.1 39.3 1.0
ND1 A:HIS108 4.1 36.6 1.0
ND1 A:HIS112 4.1 40.6 1.0
CG A:HIS112 4.1 40.5 1.0
CD A:GLN111 4.4 38.2 1.0
CB C:SER18 4.5 84.9 1.0
CA C:SER18 4.6 85.2 1.0
CA C:GLN20 4.6 86.9 1.0
CB C:ARG19 4.6 85.8 1.0
OH A:TYR831 4.8 38.0 1.0
CG C:GLN20 4.8 85.8 1.0
CB C:GLN20 4.8 86.7 1.0
CE1 A:TYR831 4.9 37.8 1.0

Reference:

M.Ren, Q.Guo, W.J.Tang. Macrophage Inflammatory Protein-1 Is A Novel High Affinity Substrate For Human Insulin Degrading Enzyme To Be Published.
Page generated: Thu Oct 24 14:12:39 2024

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