Zinc in PDB 3glu: Crystal Structure of Human SIRT3 with ACECS2 Peptide

All present enzymatic activity of Crystal Structure of Human SIRT3 with ACECS2 Peptide:
6.2.1.1;

The structure of Crystal Structure of Human SIRT3 with ACECS2 Peptide, PDB code: 3glu was solved by L.Jin, W.Wei, Y.Jiang, H.Peng, J.Cai, C.Mao, H.Dai, J.E.Bemis, M.R.Jirousek, J.C.Milne, C.H.Westphal, R.B.Perni, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	65.00 / 2.50
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	77.497, 129.460, 78.600, 90.00, 90.00, 90.00
R / Rfree (%)	20.5 / 24.8

The binding sites of Zinc atom in the Crystal Structure of Human SIRT3 with ACECS2 Peptide (pdb code 3glu). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Human SIRT3 with ACECS2 Peptide, PDB code: 3glu:

Zinc binding site 1 out of 1 in the Crystal Structure of Human SIRT3 with ACECS2 Peptide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Human SIRT3 with ACECS2 Peptide within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn400 b:26.9 occ:1.00 SG A:CYS259 2.3 31.2 1.0 SG A:CYS283 2.4 27.3 1.0 SG A:CYS280 2.4 26.2 1.0 SG A:CYS256 2.4 29.7 1.0 CB A:CYS280 3.0 26.8 1.0 CB A:CYS256 3.2 22.9 1.0 CB A:CYS283 3.4 24.9 1.0 CB A:CYS259 3.5 29.6 1.0 N A:CYS283 3.8 25.9 1.0 N A:CYS259 3.9 29.9 1.0 CA A:CYS283 4.1 25.6 1.0 CA A:CYS259 4.3 29.3 1.0 N A:GLY285 4.5 20.9 1.0 CA A:CYS280 4.5 27.5 1.0 C A:CYS283 4.6 24.4 1.0 CA A:CYS256 4.7 23.9 1.0 NH2 A:ARG261 4.7 38.8 1.0 N A:THR284 4.7 23.8 1.0 CB A:ARG261 4.7 28.8 1.0 CD A:ARG261 4.9 38.1 1.0 CB A:VAL258 4.9 29.6 1.0 C A:VAL282 4.9 27.2 1.0 CA A:GLY285 4.9 21.2 1.0 C A:CYS259 4.9 29.0 1.0 C A:VAL258 5.0 30.2 1.0

L.Jin, W.Wei, Y.Jiang, H.Peng, J.Cai, C.Mao, H.Dai, W.Choy, J.E.Bemis, M.R.Jirousek, J.C.Milne, C.H.Westphal, R.B.Perni. Crystal Structures of Human SIRT3 Displaying Substrate-Induced Conformational Changes. J.Biol.Chem. V. 284 24394 2009.
ISSN: ISSN 0021-9258
PubMed: 19535340
DOI: 10.1074/JBC.M109.014928