Zinc in PDB 3g6p: Gr Dna Binding Domain:FKBP5 Complex, 18BP

The structure of Gr Dna Binding Domain:FKBP5 Complex, 18BP, PDB code: 3g6p was solved by M.A.Pufall, K.R.Yamamoto, S.H.Meijsing, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	28.69 / 1.99
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	39.060, 100.110, 112.410, 90.00, 90.00, 90.00
R / Rfree (%)	21.4 / 23.9

The binding sites of Zinc atom in the Gr Dna Binding Domain:FKBP5 Complex, 18BP (pdb code 3g6p). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 4 binding sites of Zinc where determined in the Gr Dna Binding Domain:FKBP5 Complex, 18BP, PDB code: 3g6p:
Jump to Zinc binding site number: 1; 2; 3; 4;

Zinc binding site 1 out of 4 in the Gr Dna Binding Domain:FKBP5 Complex, 18BP


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Gr Dna Binding Domain:FKBP5 Complex, 18BP within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1514 b:51.5 occ:1.00 SG A:CYS460 2.3 42.9 0.9 SG A:CYS440 2.4 51.9 1.0 SG A:CYS457 2.4 51.1 1.0 SG A:CYS443 2.4 51.7 0.9 CB A:CYS460 3.1 48.3 1.0 CB A:CYS443 3.2 59.4 1.0 CB A:CYS440 3.3 67.4 1.0 CB A:CYS457 3.5 57.0 1.0 N A:CYS443 3.5 53.1 1.0 CA A:CYS443 3.9 59.1 1.0 N A:CYS457 4.0 58.1 1.0 N A:CYS460 4.2 37.4 1.0 CA A:CYS460 4.2 47.1 1.0 CA A:CYS457 4.3 53.0 1.0 CB A:VAL442 4.4 58.9 1.0 OG A:SER459 4.4 44.4 1.0 C A:CYS443 4.5 70.6 1.0 CB A:ASP445 4.6 71.8 1.0 NH1 A:ARG489 4.6 61.7 1.0 C A:VAL442 4.6 49.2 1.0 N A:SER444 4.7 69.2 1.0 CG1 A:VAL442 4.7 52.9 1.0 CA A:CYS440 4.8 66.2 1.0 NH2 A:ARG496 4.8 40.2 1.0 N A:ASP445 4.8 49.8 1.0 CA A:VAL442 4.9 55.9 1.0 C A:CYS457 4.9 47.8 1.0 N A:VAL442 4.9 47.8 1.0 O A:CYS457 4.9 51.0 1.0

Zinc binding site 2 out of 4 in the Gr Dna Binding Domain:FKBP5 Complex, 18BP


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Gr Dna Binding Domain:FKBP5 Complex, 18BP within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1515 b:33.8 occ:1.00 SG A:CYS482 2.2 32.0 1.0 SG A:CYS492 2.3 30.1 1.0 SG A:CYS476 2.3 32.8 1.0 SG A:CYS495 2.4 32.5 1.0 CB A:CYS482 3.2 33.0 1.0 CB A:CYS492 3.3 28.3 1.0 CB A:CYS495 3.3 30.6 1.0 CB A:CYS476 3.3 30.4 1.0 O A:HOH2 3.7 31.4 1.0 N A:CYS482 3.9 37.9 1.0 CA A:CYS476 4.0 28.1 1.0 CA A:CYS482 4.2 39.4 1.0 O A:HOH526 4.2 35.6 1.0 N A:CYS495 4.3 30.7 1.0 CA A:CYS495 4.4 37.3 1.0 CA A:ASN480 4.5 38.9 1.0 N A:ASN480 4.6 38.6 1.0 N A:ASP481 4.6 38.6 1.0 N A:ALA477 4.7 27.8 1.0 CA A:CYS492 4.7 27.7 1.0 O B:HOH4 4.7 35.6 1.0 C A:ASN480 4.8 47.1 1.0 C A:CYS476 4.8 33.0 1.0 N A:GLY478 4.9 34.4 1.0

Zinc binding site 3 out of 4 in the Gr Dna Binding Domain:FKBP5 Complex, 18BP


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Gr Dna Binding Domain:FKBP5 Complex, 18BP within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1512 b:49.6 occ:1.00 SG B:CYS440 2.2 46.0 1.0 SG B:CYS460 2.3 42.7 1.0 SG B:CYS457 2.3 53.0 1.0 SG B:CYS443 2.4 46.2 0.9 CB B:CYS440 3.0 67.7 1.0 CB B:CYS443 3.2 54.7 1.0 CB B:CYS460 3.2 43.7 1.0 CB B:CYS457 3.5 57.5 1.0 N B:CYS443 3.6 43.5 1.0 CA B:CYS443 3.9 57.1 1.0 N B:CYS457 3.9 47.9 1.0 N B:CYS460 4.2 36.0 1.0 CA B:CYS457 4.3 49.9 1.0 CA B:CYS460 4.3 41.0 1.0 OG B:SER459 4.4 48.9 1.0 CB B:VAL442 4.4 37.5 1.0 C B:CYS443 4.4 68.1 1.0 CB B:ASP445 4.5 67.4 1.0 CA B:CYS440 4.5 67.1 1.0 N B:SER444 4.6 79.8 1.0 C B:VAL442 4.6 60.5 1.0 N B:ASP445 4.7 61.0 1.0 NH1 B:ARG489 4.7 47.2 1.0 NH2 B:ARG496 4.8 48.6 1.0 C B:CYS457 4.9 48.7 1.0 O B:CYS457 4.9 44.8 1.0 CA B:VAL442 4.9 52.3 1.0 N B:VAL442 4.9 55.7 1.0 CG1 B:VAL442 5.0 46.4 1.0 C B:CYS440 5.0 64.2 1.0

Zinc binding site 4 out of 4 in the Gr Dna Binding Domain:FKBP5 Complex, 18BP


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Gr Dna Binding Domain:FKBP5 Complex, 18BP within 5.0Å range: probe atom residue distance (Å) B Occ B:Zn1513 b:31.4 occ:1.00 SG B:CYS482 2.3 32.0 1.0 SG B:CYS476 2.3 33.2 1.0 SG B:CYS495 2.3 32.0 1.0 SG B:CYS492 2.4 31.9 1.0 CB B:CYS482 3.2 38.7 1.0 CB B:CYS492 3.3 33.2 1.0 CB B:CYS476 3.3 27.2 1.0 CB B:CYS495 3.3 26.6 1.0 O B:HOH1 3.8 31.4 1.0 N B:CYS482 3.9 33.1 1.0 CA B:CYS476 4.0 36.6 1.0 CA B:CYS482 4.2 44.4 1.0 N B:CYS495 4.2 25.2 1.0 CA B:CYS495 4.3 29.8 1.0 CA B:ASN480 4.4 48.5 1.0 N B:ASN480 4.5 44.7 1.0 O B:HOH4 4.6 35.6 1.0 O B:HOH49 4.6 57.2 1.0 N B:ASP481 4.6 39.5 1.0 O B:HOH5 4.6 32.6 1.0 CA B:CYS492 4.7 30.6 1.0 N B:ALA477 4.7 31.0 1.0 C B:ASN480 4.8 42.0 1.0 N B:GLY478 4.8 37.4 1.0 C B:CYS476 4.8 39.5 1.0 CB B:ALA494 5.0 27.2 1.0

S.H.Meijsing, M.A.Pufall, A.Y.So, D.L.Bates, L.Chen, K.R.Yamamoto. Dna Binding Site Sequence Directs Glucocorticoid Receptor Structure and Activity. Science V. 324 407 2009.
ISSN: ISSN 0036-8075
PubMed: 19372434
DOI: 10.1126/SCIENCE.1164265