Zinc in PDB 4aa1: Crystal Structure of Ance in Complex with Angiotensin-II

All present enzymatic activity of Crystal Structure of Ance in Complex with Angiotensin-II:
3.4.15.1;

The structure of Crystal Structure of Ance in Complex with Angiotensin-II, PDB code: 4aa1 was solved by R.E.Isaac, M.Akif, S.L.U.Schwager, G.Masuyer, E.D.Sturrock, K.R.Acharya, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	38.57 / 1.99
Space group	H 3
Cell size a, b, c (Å), α, β, γ (°)	173.414, 173.414, 102.245, 90.00, 90.00, 120.00
R / Rfree (%)	18.835 / 21.072

The binding sites of Zinc atom in the Crystal Structure of Ance in Complex with Angiotensin-II (pdb code 4aa1). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Ance in Complex with Angiotensin-II, PDB code: 4aa1:

Zinc binding site 1 out of 1 in the Crystal Structure of Ance in Complex with Angiotensin-II


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Ance in Complex with Angiotensin-II within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1615 b:35.0 occ:1.00 OE1 A:GLU395 2.0 29.6 1.0 NE2 A:HIS371 2.0 28.9 1.0 NE2 A:HIS367 2.1 32.4 1.0 O P:ILE4 2.2 51.6 1.0 CD A:GLU395 2.9 29.1 1.0 CE1 A:HIS371 3.0 29.3 1.0 CE1 A:HIS367 3.0 32.3 1.0 C P:ILE4 3.0 51.8 1.0 CD2 A:HIS367 3.1 31.9 1.0 CD2 A:HIS371 3.1 28.9 1.0 OE2 A:GLU395 3.2 30.1 1.0 N P:HIS5 3.7 50.7 1.0 N P:ILE4 3.8 53.0 1.0 CA P:ILE4 3.9 52.4 1.0 CA P:HIS5 4.0 49.8 1.0 C P:TYR3 4.1 53.6 1.0 ND1 A:HIS367 4.1 32.0 1.0 ND1 A:HIS371 4.1 28.8 1.0 O P:TYR3 4.1 53.5 1.0 CG A:HIS367 4.2 32.0 1.0 CG A:HIS371 4.2 29.1 1.0 CG A:GLU395 4.3 28.8 1.0 CE1 A:TYR507 4.3 30.4 1.0 OE2 A:GLU368 4.4 35.5 1.0 OH A:TYR507 4.4 32.4 1.0 CA A:GLU395 4.5 28.5 1.0 OE1 A:GLU368 4.5 34.2 1.0 CB A:GLU395 4.6 28.4 1.0 C P:HIS5 4.8 48.7 1.0 CD A:GLU368 4.8 34.1 1.0 CD P:PRO6 4.8 47.8 1.0 CZ A:TYR507 4.9 30.7 1.0 CB P:TYR3 5.0 54.1 1.0 CA P:TYR3 5.0 54.0 1.0

M.Akif, G.Masuyer, R.J.Bingham, E.D.Sturrock, R.E.Isaac, K.R.Acharya. Structural Basis of Peptide Recognition By the Angiotensin-I Converting Enzyme Homologue Ance From Drosophila Melanogaster Febs J. V. 279 4525 2012.
ISSN: ISSN 1742-464X
PubMed: 23082758
DOI: 10.1111/FEBS.12038