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Zinc in PDB 3fun: Leukotriene A4 Hydrolase in Complex with {4-[(2R)- Pyrrolidin-2-Ylmethoxy]Phenyl}(4-Thiophen-3-Ylphenyl) MethanoneEnzymatic activity of Leukotriene A4 Hydrolase in Complex with {4-[(2R)- Pyrrolidin-2-Ylmethoxy]Phenyl}(4-Thiophen-3-Ylphenyl) Methanone
All present enzymatic activity of Leukotriene A4 Hydrolase in Complex with {4-[(2R)- Pyrrolidin-2-Ylmethoxy]Phenyl}(4-Thiophen-3-Ylphenyl) Methanone:
3.3.2.6; Protein crystallography data
The structure of Leukotriene A4 Hydrolase in Complex with {4-[(2R)- Pyrrolidin-2-Ylmethoxy]Phenyl}(4-Thiophen-3-Ylphenyl) Methanone, PDB code: 3fun
was solved by
D.R.Davies,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 3fun:
The structure of Leukotriene A4 Hydrolase in Complex with {4-[(2R)- Pyrrolidin-2-Ylmethoxy]Phenyl}(4-Thiophen-3-Ylphenyl) Methanone also contains other interesting chemical elements:
Zinc Binding Sites:
The binding sites of Zinc atom in the Leukotriene A4 Hydrolase in Complex with {4-[(2R)- Pyrrolidin-2-Ylmethoxy]Phenyl}(4-Thiophen-3-Ylphenyl) Methanone
(pdb code 3fun). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Leukotriene A4 Hydrolase in Complex with {4-[(2R)- Pyrrolidin-2-Ylmethoxy]Phenyl}(4-Thiophen-3-Ylphenyl) Methanone, PDB code: 3fun: Zinc binding site 1 out of 1 in 3funGo back to Zinc Binding Sites List in 3fun
Zinc binding site 1 out
of 1 in the Leukotriene A4 Hydrolase in Complex with {4-[(2R)- Pyrrolidin-2-Ylmethoxy]Phenyl}(4-Thiophen-3-Ylphenyl) Methanone
Mono view Stereo pair view
Reference:
D.R.Davies,
B.Mamat,
O.T.Magnusson,
J.Christensen,
M.H.Haraldsson,
R.Mishra,
B.Pease,
E.Hansen,
J.Singh,
D.Zembower,
H.Kim,
A.S.Kiselyov,
A.B.Burgin,
M.E.Gurney,
L.J.Stewart.
Discovery of Leukotriene A4 Hydrolase Inhibitors Using Metabolomics Biased Fragment Crystallography. J.Med.Chem. V. 52 4694 2009.
Page generated: Thu Oct 24 13:26:39 2024
ISSN: ISSN 0022-2623 PubMed: 19618939 DOI: 10.1021/JM900259H |
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