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Zinc in PDB 3fee: The High Resolution Structure of Human Glutamate Carboxypeptidase III (Gcpiii/Naaladase II) in Complex with Quisqualic Acid

Enzymatic activity of The High Resolution Structure of Human Glutamate Carboxypeptidase III (Gcpiii/Naaladase II) in Complex with Quisqualic Acid

All present enzymatic activity of The High Resolution Structure of Human Glutamate Carboxypeptidase III (Gcpiii/Naaladase II) in Complex with Quisqualic Acid:
3.4.17.21;

Protein crystallography data

The structure of The High Resolution Structure of Human Glutamate Carboxypeptidase III (Gcpiii/Naaladase II) in Complex with Quisqualic Acid, PDB code: 3fee was solved by J.Lubkowski, C.Barinka, K.Hlouchova, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 25.00 / 1.56
Space group C 1 2 1
Cell size a, b, c (Å), α, β, γ (°) 122.985, 103.690, 77.611, 90.00, 108.27, 90.00
R / Rfree (%) 14.9 / 18.4

Other elements in 3fee:

The structure of The High Resolution Structure of Human Glutamate Carboxypeptidase III (Gcpiii/Naaladase II) in Complex with Quisqualic Acid also contains other interesting chemical elements:

Chlorine (Cl) 1 atom
Calcium (Ca) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the The High Resolution Structure of Human Glutamate Carboxypeptidase III (Gcpiii/Naaladase II) in Complex with Quisqualic Acid (pdb code 3fee). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the The High Resolution Structure of Human Glutamate Carboxypeptidase III (Gcpiii/Naaladase II) in Complex with Quisqualic Acid, PDB code: 3fee:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 3fee

Go back to Zinc Binding Sites List in 3fee
Zinc binding site 1 out of 2 in the The High Resolution Structure of Human Glutamate Carboxypeptidase III (Gcpiii/Naaladase II) in Complex with Quisqualic Acid


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of The High Resolution Structure of Human Glutamate Carboxypeptidase III (Gcpiii/Naaladase II) in Complex with Quisqualic Acid within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1751

b:14.8
occ:0.80
 OD2 A:ASP377 2.0 13.7 1.0
O A:HOH1497 2.0 14.4 0.9
NE2 A:HIS543 2.1 13.0 1.0
OE2 A:GLU415 2.1 15.1 1.0
OE1 A:GLU415 2.4 11.8 1.0
O A:HOH1498 2.6 23.6 0.8
CD A:GLU415 2.6 13.4 1.0
CG A:ASP377 2.9 13.5 1.0
CE1 A:HIS543 3.0 14.7 1.0
CD2 A:HIS543 3.1 14.6 1.0
OD1 A:ASP377 3.3 13.9 1.0
ZN A:ZN1752 3.7 11.9 0.5
O A:HOH1190 3.9 19.3 0.5
O A:HOH952 4.0 11.4 1.0
C02 A:QUS741 4.1 11.4 1.0
OE1 A:GLU414 4.1 13.6 1.0
CG A:GLU415 4.1 12.2 1.0
ND1 A:HIS543 4.1 12.2 1.0
CE1 A:TYR542 4.1 14.7 1.0
OH A:TYR542 4.2 14.6 1.0
NP3 A:QUS741 4.2 13.5 1.0
CG A:HIS543 4.2 11.8 1.0
CB A:ASP377 4.3 11.6 1.0
C01 A:QUS741 4.4 13.1 1.0
CZ A:TYR542 4.6 14.2 1.0
CE1 A:HIS367 4.6 11.8 1.0
CD1 A:TRP371 4.6 11.4 1.0
O17 A:QUS741 4.7 11.7 1.0
NE2 A:HIS367 4.7 12.1 1.0
NE1 A:TRP371 4.7 11.9 1.0
O16 A:QUS741 5.0 13.7 1.0

Zinc binding site 2 out of 2 in 3fee

Go back to Zinc Binding Sites List in 3fee
Zinc binding site 2 out of 2 in the The High Resolution Structure of Human Glutamate Carboxypeptidase III (Gcpiii/Naaladase II) in Complex with Quisqualic Acid


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of The High Resolution Structure of Human Glutamate Carboxypeptidase III (Gcpiii/Naaladase II) in Complex with Quisqualic Acid within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn1752

b:11.9
occ:0.45
 O A:HOH1190 2.0 19.3 0.5
OD1 A:ASP377 2.0 13.9 1.0
NE2 A:HIS367 2.1 12.1 1.0
OD1 A:ASP443 2.3 15.4 1.0
O A:HOH1497 2.4 14.4 0.9
OD2 A:ASP443 2.5 17.2 1.0
CG A:ASP443 2.8 14.1 1.0
CE1 A:HIS367 2.9 11.8 1.0
CG A:ASP377 3.0 13.5 1.0
CD2 A:HIS367 3.1 12.4 1.0
OD2 A:ASP377 3.4 13.7 1.0
ZN A:ZN1751 3.7 14.8 0.8
OE1 A:GLU414 3.9 13.6 1.0
O A:HOH1499 4.1 24.5 0.7
CD A:GLU414 4.1 12.8 1.0
ND1 A:HIS367 4.1 10.9 1.0
OE2 A:GLU414 4.1 13.9 1.0
OE2 A:GLU415 4.2 15.1 1.0
CG A:HIS367 4.2 11.6 1.0
CB A:ASP377 4.2 11.6 1.0
CB A:PRO378 4.3 10.9 1.0
O A:HOH1498 4.3 23.6 0.8
CB A:ASP443 4.3 12.5 1.0
OG A:SER444 4.3 15.4 1.0
CA A:PRO378 4.5 10.1 1.0
CA A:ASP377 4.6 11.2 1.0
N A:PRO378 4.6 11.3 1.0
C A:ASP377 4.7 11.7 1.0
NP3 A:QUS741 4.8 13.5 1.0
N A:SER444 4.9 11.7 1.0
CD A:GLU415 4.9 13.4 1.0
OG A:SER509 4.9 11.4 1.0

Reference:

K.Hlouchova, C.Barinka, J.Konvalinka, J.Lubkowski. Structural Insight Into the Evolutionary and Pharmacologic Homology of Glutamate Carboxypeptidases II and III Febs J. V. 276 4448 2009.
ISSN: ISSN 1742-464X
PubMed: 19678840
DOI: 10.1111/J.1742-4658.2009.07152.X
Page generated: Wed Aug 20 09:10:05 2025

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