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Zinc in PDB 3eah: Structure of Inhibited Human Enos Oxygenase Domain

Enzymatic activity of Structure of Inhibited Human Enos Oxygenase Domain

All present enzymatic activity of Structure of Inhibited Human Enos Oxygenase Domain:
1.14.13.39;

Protein crystallography data

The structure of Structure of Inhibited Human Enos Oxygenase Domain, PDB code: 3eah was solved by E.D.Garcin, A.S.Arvai, R.J.Rosenfeld, M.D.Kroeger, B.R.Crane, G.Andersson, G.Andrews, P.J.Hamley, P.R.Mallinder, D.J.Nicholls, S.A.St-Gallay, A.C.Tinker, N.P.Gensmantel, A.Mete, D.R.Cheshire, S.Connolly, D.J.Stuehr, A.Aberg, A.V.Wallace, J.A.Tainer, E.D.Getzoff, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 25.00 / 2.44
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 71.090, 90.150, 156.100, 90.00, 90.00, 90.00
R / Rfree (%) 21.3 / 25.8

Other elements in 3eah:

The structure of Structure of Inhibited Human Enos Oxygenase Domain also contains other interesting chemical elements:

Iron (Fe) 2 atoms
Chlorine (Cl) 2 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Structure of Inhibited Human Enos Oxygenase Domain (pdb code 3eah). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Structure of Inhibited Human Enos Oxygenase Domain, PDB code: 3eah:

Zinc binding site 1 out of 1 in 3eah

Go back to Zinc Binding Sites List in 3eah
Zinc binding site 1 out of 1 in the Structure of Inhibited Human Enos Oxygenase Domain


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Structure of Inhibited Human Enos Oxygenase Domain within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn862

b:39.7
occ:1.00
SG A:CYS63 2.3 40.9 1.0
SG B:CYS63 2.3 42.6 1.0
SG A:CYS68 2.4 36.3 1.0
SG B:CYS68 2.4 37.9 1.0
CB B:CYS63 3.2 45.4 1.0
CB B:CYS68 3.2 41.2 1.0
CB A:CYS63 3.3 42.2 1.0
CB A:CYS68 3.3 37.2 1.0
CA A:CYS68 3.8 36.8 1.0
CA B:CYS68 3.8 41.8 1.0
N B:GLY70 4.0 44.4 1.0
N A:GLY70 4.1 35.0 1.0
N A:LEU69 4.1 36.3 1.0
N B:LEU69 4.2 43.9 1.0
CA B:GLY70 4.3 43.8 1.0
C A:CYS68 4.4 36.7 1.0
C B:CYS68 4.4 42.9 1.0
CA A:GLY70 4.4 34.5 1.0
CA B:CYS63 4.6 47.1 1.0
CA A:CYS63 4.6 44.3 1.0

Reference:

E.D.Garcin, A.S.Arvai, R.J.Rosenfeld, M.D.Kroeger, B.R.Crane, G.Andersson, G.Andrews, P.J.Hamley, P.R.Mallinder, D.J.Nicholls, S.A.St-Gallay, A.C.Tinker, N.P.Gensmantel, A.Mete, D.R.Cheshire, S.Connolly, D.J.Stuehr, A.Aberg, A.V.Wallace, J.A.Tainer, E.D.Getzoff. Anchored Plasticity Opens Doors For Selective Inhibitor Design in Nitric Oxide Synthase. Nat.Chem.Biol. V. 4 700 2008.
ISSN: ISSN 1552-4450
PubMed: 18849972
DOI: 10.1038/NCHEMBIO.115
Page generated: Thu Oct 24 12:41:50 2024

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