Atomistry » Zinc » PDB 3ciz-3cyu » 3cqp
Atomistry »
  Zinc »
    PDB 3ciz-3cyu »
      3cqp »

Zinc in PDB 3cqp: Human SOD1 G85R Variant, Structure I

Enzymatic activity of Human SOD1 G85R Variant, Structure I

All present enzymatic activity of Human SOD1 G85R Variant, Structure I:
1.15.1.1;

Protein crystallography data

The structure of Human SOD1 G85R Variant, Structure I, PDB code: 3cqp was solved by X.Cao, S.Antonyuk, S.V.Seetharaman, L.J.Whitson, A.B.Taylor, S.P.Holloway, R.W.Strange, P.A.Doucette, J.S.Valentine, A.Tiwari, L.J.Hayward, S.Padua, J.A.Cohlberg, S.S.Hasnain, P.J.Hart, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.00 / 1.95
Space group I 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 73.472, 116.808, 147.764, 90.00, 90.00, 90.00
R / Rfree (%) 18.3 / 22.3

Other elements in 3cqp:

The structure of Human SOD1 G85R Variant, Structure I also contains other interesting chemical elements:

Copper (Cu) 4 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Human SOD1 G85R Variant, Structure I (pdb code 3cqp). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 3 binding sites of Zinc where determined in the Human SOD1 G85R Variant, Structure I, PDB code: 3cqp:
Jump to Zinc binding site number: 1; 2; 3;

Zinc binding site 1 out of 3 in 3cqp

Go back to Zinc Binding Sites List in 3cqp
Zinc binding site 1 out of 3 in the Human SOD1 G85R Variant, Structure I


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Human SOD1 G85R Variant, Structure I within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn155

b:24.4
occ:1.00
ND1 A:HIS63 1.9 16.4 1.0
OD1 A:ASP83 2.0 17.2 1.0
ND1 A:HIS80 2.1 16.0 1.0
ND1 A:HIS71 2.1 17.4 1.0
CG A:ASP83 2.7 16.0 1.0
OD2 A:ASP83 2.8 17.3 1.0
CE1 A:HIS63 2.9 18.5 1.0
CE1 A:HIS80 2.9 16.6 1.0
CE1 A:HIS71 3.0 17.9 1.0
CG A:HIS63 3.0 17.1 1.0
CG A:HIS80 3.1 15.6 1.0
CG A:HIS71 3.2 17.6 1.0
CB A:HIS63 3.4 17.0 1.0
CB A:HIS80 3.5 15.4 1.0
CB A:HIS71 3.6 18.1 1.0
O A:LYS136 3.8 22.9 1.0
CA A:HIS71 4.0 18.4 1.0
NE2 A:HIS63 4.0 18.9 1.0
NE2 A:HIS80 4.1 17.0 1.0
CD2 A:HIS63 4.1 18.9 1.0
CD2 A:HIS80 4.1 16.4 1.0
NE2 A:HIS71 4.1 18.3 1.0
CB A:ASP83 4.2 17.3 1.0
CD2 A:HIS71 4.3 18.8 1.0
N A:GLY72 4.6 18.3 1.0
N A:HIS80 4.7 16.8 1.0
CA A:HIS80 4.7 16.3 1.0
CA A:ASP83 4.7 16.7 1.0
C A:LYS136 4.8 23.2 1.0
C A:HIS71 4.9 18.5 1.0
CD2 A:HIS46 4.9 17.9 1.0
N A:ASP83 4.9 16.2 1.0
O A:HOH171 4.9 18.3 1.0
CA A:HIS63 5.0 16.9 1.0

Zinc binding site 2 out of 3 in 3cqp

Go back to Zinc Binding Sites List in 3cqp
Zinc binding site 2 out of 3 in the Human SOD1 G85R Variant, Structure I


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Human SOD1 G85R Variant, Structure I within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn155

b:23.9
occ:1.00
OD1 B:ASP83 2.0 19.3 1.0
ND1 B:HIS80 2.0 17.6 1.0
ND1 B:HIS63 2.1 17.4 1.0
ND1 B:HIS71 2.1 16.9 1.0
CG B:ASP83 2.8 19.0 1.0
OD2 B:ASP83 2.9 21.4 1.0
CE1 B:HIS71 2.9 16.4 1.0
CE1 B:HIS80 3.0 18.8 1.0
CE1 B:HIS63 3.0 17.8 1.0
CG B:HIS80 3.1 18.6 1.0
CG B:HIS63 3.1 17.6 1.0
CG B:HIS71 3.2 18.8 1.0
CB B:HIS63 3.4 17.0 1.0
CB B:HIS80 3.5 18.2 1.0
CB B:HIS71 3.7 20.2 1.0
O B:LYS136 3.9 20.2 1.0
CA B:HIS71 4.0 21.6 1.0
NE2 B:HIS80 4.1 18.9 1.0
NE2 B:HIS71 4.1 16.5 1.0
CD2 B:HIS80 4.1 18.7 1.0
NE2 B:HIS63 4.2 17.4 1.0
CD2 B:HIS63 4.2 17.9 1.0
CB B:ASP83 4.2 19.3 1.0
CD2 B:HIS71 4.3 18.8 1.0
N B:GLY72 4.7 23.0 1.0
N B:HIS80 4.7 20.2 1.0
CA B:HIS80 4.7 19.3 1.0
CA B:ASP83 4.7 18.6 1.0
O B:HOH161 4.8 16.7 1.0
C B:LYS136 4.9 20.5 1.0
CD2 B:HIS46 4.9 17.4 1.0
C B:HIS71 4.9 22.2 1.0
CA B:HIS63 4.9 17.0 1.0
N B:ASP83 5.0 18.8 1.0
N B:HIS71 5.0 21.9 1.0

Zinc binding site 3 out of 3 in 3cqp

Go back to Zinc Binding Sites List in 3cqp
Zinc binding site 3 out of 3 in the Human SOD1 G85R Variant, Structure I


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Human SOD1 G85R Variant, Structure I within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Zn155

b:24.5
occ:1.00
OD1 D:ASP83 1.9 15.9 1.0
ND1 D:HIS80 2.0 15.6 1.0
ND1 D:HIS63 2.1 21.7 1.0
ND1 D:HIS71 2.1 18.1 1.0
CG D:ASP83 2.7 17.9 1.0
OD2 D:ASP83 2.9 17.4 1.0
CE1 D:HIS80 2.9 17.3 1.0
CE1 D:HIS71 2.9 18.6 1.0
CE1 D:HIS63 3.0 23.6 1.0
CG D:HIS63 3.1 21.7 1.0
CG D:HIS80 3.1 16.8 1.0
CG D:HIS71 3.2 19.9 1.0
CB D:HIS63 3.4 20.6 1.0
CB D:HIS80 3.6 16.4 1.0
CB D:HIS71 3.6 20.8 1.0
CA D:HIS71 3.9 20.4 1.0
NE2 D:HIS80 4.0 18.3 1.0
O D:LYS136 4.1 26.8 1.0
NE2 D:HIS71 4.1 19.7 1.0
NE2 D:HIS63 4.1 24.6 1.0
CD2 D:HIS80 4.2 17.6 1.0
CB D:ASP83 4.2 18.3 1.0
CD2 D:HIS63 4.2 23.8 1.0
CD2 D:HIS71 4.3 20.6 1.0
N D:GLY72 4.6 20.5 1.0
N D:HIS80 4.7 16.9 1.0
CA D:ASP83 4.7 18.0 1.0
CA D:HIS80 4.8 17.0 1.0
C D:HIS71 4.8 20.7 1.0
N D:ASP83 4.9 17.7 1.0
N D:HIS71 4.9 21.4 1.0
CA D:HIS63 4.9 20.0 1.0
O D:HOH222 4.9 32.6 1.0
CD2 D:HIS46 4.9 18.7 1.0
C D:LYS136 5.0 27.1 1.0

Reference:

X.Cao, S.V.Antonyuk, S.V.Seetharaman, L.J.Whitson, A.B.Taylor, S.P.Holloway, R.W.Strange, P.A.Doucette, J.S.Valentine, A.Tiwari, L.J.Hayward, S.Padua, J.A.Cohlberg, S.S.Hasnain, P.J.Hart. Structures of the G85R Variant of SOD1 in Familial Amyotrophic Lateral Sclerosis. J.Biol.Chem. V. 283 16169 2008.
ISSN: ISSN 0021-9258
PubMed: 18378676
DOI: 10.1074/JBC.M801522200
Page generated: Wed Dec 16 04:11:13 2020

Last articles

Zn in 7NN0
Zn in 7NIO
Zn in 7LUP
Zn in 7M1Y
Zn in 7LO4
Zn in 7KWO
Zn in 7KJY
Zn in 7KCQ
Zn in 7KC2
Zn in 7KCB
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy