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Zinc in PDB 3chr: Crystal Structure of Leukotriene A4 Hydrolase in Complex with 4-Amino- N-[4-(Phenylmethoxy)Phenyl]-Butanamide

Enzymatic activity of Crystal Structure of Leukotriene A4 Hydrolase in Complex with 4-Amino- N-[4-(Phenylmethoxy)Phenyl]-Butanamide

All present enzymatic activity of Crystal Structure of Leukotriene A4 Hydrolase in Complex with 4-Amino- N-[4-(Phenylmethoxy)Phenyl]-Butanamide:
3.3.2.6;

Protein crystallography data

The structure of Crystal Structure of Leukotriene A4 Hydrolase in Complex with 4-Amino- N-[4-(Phenylmethoxy)Phenyl]-Butanamide, PDB code: 3chr was solved by M.M.G.M.Thunnissen, M.Adler, M.Whitlow, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 17.62 / 2.20
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 67.346, 133.210, 83.100, 90.00, 90.00, 90.00
R / Rfree (%) 20.7 / 26.7

Other elements in 3chr:

The structure of Crystal Structure of Leukotriene A4 Hydrolase in Complex with 4-Amino- N-[4-(Phenylmethoxy)Phenyl]-Butanamide also contains other interesting chemical elements:

Ytterbium (Yb) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Leukotriene A4 Hydrolase in Complex with 4-Amino- N-[4-(Phenylmethoxy)Phenyl]-Butanamide (pdb code 3chr). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Leukotriene A4 Hydrolase in Complex with 4-Amino- N-[4-(Phenylmethoxy)Phenyl]-Butanamide, PDB code: 3chr:

Zinc binding site 1 out of 1 in 3chr

Go back to Zinc Binding Sites List in 3chr
Zinc binding site 1 out of 1 in the Crystal Structure of Leukotriene A4 Hydrolase in Complex with 4-Amino- N-[4-(Phenylmethoxy)Phenyl]-Butanamide


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Leukotriene A4 Hydrolase in Complex with 4-Amino- N-[4-(Phenylmethoxy)Phenyl]-Butanamide within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn611

b:29.2
occ:1.00
 OE1 A:GLU318 1.9 18.7 1.0
NE2 A:HIS295 2.0 23.3 1.0
NE2 A:HIS299 2.1 29.1 1.0
O A:HOH627 2.3 32.4 1.0
CD A:GLU318 2.5 25.8 1.0
OE2 A:GLU318 2.6 25.3 1.0
CE1 A:HIS295 2.9 24.7 1.0
CE1 A:HIS299 3.0 25.7 1.0
CD2 A:HIS295 3.0 23.9 1.0
CD2 A:HIS299 3.1 28.5 1.0
N1 A:4BS613 3.9 27.9 1.0
CE2 A:TYR383 3.9 22.5 1.0
CG A:GLU318 4.0 24.0 1.0
ND1 A:HIS295 4.1 26.1 1.0
OH A:TYR383 4.1 25.0 1.0
ND1 A:HIS299 4.1 26.4 1.0
CG A:HIS295 4.1 24.4 1.0
CG A:HIS299 4.2 28.9 1.0
CG2 A:THR321 4.4 26.9 1.0
CZ A:TYR383 4.4 23.1 1.0
OE1 A:GLU271 4.4 27.4 1.0
C2 A:4BS613 4.4 27.6 1.0
CB A:THR321 4.6 27.2 1.0
CB A:GLU318 4.7 24.6 1.0
O A:HOH685 4.7 26.2 1.0
CD2 A:TYR383 4.8 21.9 1.0
CA A:GLU318 4.8 24.9 1.0
OG1 A:THR321 4.9 26.1 1.0
OE2 A:GLU296 4.9 33.1 1.0
CD A:GLU271 4.9 29.2 1.0
OE2 A:GLU271 5.0 27.6 1.0

Reference:

T.A.Kirkland, M.Adler, J.G.Bauman, M.Chen, J.Z.Haeggstrom, B.King, M.J.Kochanny, A.M.Liang, L.Mendoza, G.B.Phillips, M.Thunnissen, L.Trinh, M.Whitlow, B.Ye, H.Ye, J.Parkinson, W.J.Guilford. Synthesis of Glutamic Acid Analogs As Potent Inhibitors of Leukotriene A4 Hydrolase. Bioorg.Med.Chem. V. 16 4963 2008.
ISSN: ISSN 0968-0896
PubMed: 18394906
DOI: 10.1016/J.BMC.2008.03.042
Page generated: Thu Oct 24 11:48:54 2024

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