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Zinc in PDB 3chp: Crystal Structure of Leukotriene A4 Hydrolase in Complex with (3S)-3- Amino-4-Oxo-4-[(4-Phenylmethoxyphenyl)Amino]Butanoic Acid

Enzymatic activity of Crystal Structure of Leukotriene A4 Hydrolase in Complex with (3S)-3- Amino-4-Oxo-4-[(4-Phenylmethoxyphenyl)Amino]Butanoic Acid

All present enzymatic activity of Crystal Structure of Leukotriene A4 Hydrolase in Complex with (3S)-3- Amino-4-Oxo-4-[(4-Phenylmethoxyphenyl)Amino]Butanoic Acid:
3.3.2.6;

Protein crystallography data

The structure of Crystal Structure of Leukotriene A4 Hydrolase in Complex with (3S)-3- Amino-4-Oxo-4-[(4-Phenylmethoxyphenyl)Amino]Butanoic Acid, PDB code: 3chp was solved by M.M.G.M.Thunnissen, M.Adler, M.Whitlow, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 24.85 / 2.10
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 67.767, 133.572, 83.629, 90.00, 90.00, 90.00
R / Rfree (%) n/a / n/a

Other elements in 3chp:

The structure of Crystal Structure of Leukotriene A4 Hydrolase in Complex with (3S)-3- Amino-4-Oxo-4-[(4-Phenylmethoxyphenyl)Amino]Butanoic Acid also contains other interesting chemical elements:

Ytterbium (Yb) 1 atom

Zinc Binding Sites:

The binding sites of Zinc atom in the Crystal Structure of Leukotriene A4 Hydrolase in Complex with (3S)-3- Amino-4-Oxo-4-[(4-Phenylmethoxyphenyl)Amino]Butanoic Acid (pdb code 3chp). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the Crystal Structure of Leukotriene A4 Hydrolase in Complex with (3S)-3- Amino-4-Oxo-4-[(4-Phenylmethoxyphenyl)Amino]Butanoic Acid, PDB code: 3chp:

Zinc binding site 1 out of 1 in 3chp

Go back to Zinc Binding Sites List in 3chp
Zinc binding site 1 out of 1 in the Crystal Structure of Leukotriene A4 Hydrolase in Complex with (3S)-3- Amino-4-Oxo-4-[(4-Phenylmethoxyphenyl)Amino]Butanoic Acid


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of Leukotriene A4 Hydrolase in Complex with (3S)-3- Amino-4-Oxo-4-[(4-Phenylmethoxyphenyl)Amino]Butanoic Acid within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Zn701

b:23.6
occ:1.00
 OE1 A:GLU318 2.0 18.2 1.0
NE2 A:HIS295 2.1 15.5 1.0
NE2 A:HIS299 2.1 23.6 1.0
OE2 A:GLU318 2.4 21.9 1.0
CD A:GLU318 2.5 20.2 1.0
O3 A:4BO901 2.8 49.1 1.0
CE1 A:HIS295 3.0 15.7 1.0
CE1 A:HIS299 3.0 15.9 1.0
CD2 A:HIS295 3.2 13.9 1.0
CD2 A:HIS299 3.2 19.1 1.0
C2 A:4BO901 3.7 47.0 1.0
CE2 A:TYR383 3.7 18.0 1.0
O1 A:4BO901 4.0 35.6 1.0
OH A:TYR383 4.0 20.2 1.0
CG A:GLU318 4.0 16.7 1.0
ND1 A:HIS295 4.2 16.9 1.0
ND1 A:HIS299 4.2 21.2 1.0
CG A:HIS295 4.3 16.2 1.0
CZ A:TYR383 4.3 21.4 1.0
CG A:HIS299 4.3 20.8 1.0
O A:HOH1322 4.4 23.6 1.0
CG2 A:THR321 4.4 21.1 1.0
CD2 A:TYR383 4.6 17.0 1.0
OE1 A:GLU271 4.6 22.4 1.0
CB A:THR321 4.7 21.8 1.0
CB A:GLU318 4.7 18.4 1.0
CA A:GLU318 4.8 22.5 1.0
OE2 A:GLU271 4.9 21.9 1.0
CD A:GLU271 5.0 23.0 1.0

Reference:

T.A.Kirkland, M.Adler, J.G.Bauman, M.Chen, J.Z.Haeggstrom, B.King, M.J.Kochanny, A.M.Liang, L.Mendoza, G.B.Phillips, M.Thunnissen, L.Trinh, M.Whitlow, B.Ye, H.Ye, J.Parkinson, W.J.Guilford. Synthesis of Glutamic Acid Analogs As Potent Inhibitors of Leukotriene A4 Hydrolase. Bioorg.Med.Chem. V. 16 4963 2008.
ISSN: ISSN 0968-0896
PubMed: 18394906
DOI: 10.1016/J.BMC.2008.03.042
Page generated: Thu Oct 24 11:48:34 2024

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