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Zinc in PDB 3bi1: X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Transition State Analog of Methotrexate-Glu
Enzymatic activity of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Transition State Analog of Methotrexate-Glu
All present enzymatic activity of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Transition State Analog of Methotrexate-Glu:
3.4.17.21;
3.4.17.21;
Protein crystallography data
The structure of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Transition State Analog of Methotrexate-Glu, PDB code: 3bi1
was solved by
C.Barinka,
J.Lubkowski,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 15.00 / 1.50 |
| Space group | I 2 2 2 |
| Cell size a, b, c (Å), α, β, γ (°) | 102.116, 130.462, 159.456, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 14.8 / 16.9 |
Other elements in 3bi1:
The structure of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Transition State Analog of Methotrexate-Glu also contains other interesting chemical elements:
| Chlorine | (Cl) | 1 atom |
| Calcium | (Ca) | 1 atom |
Zinc Binding Sites:
The binding sites of Zinc atom in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Transition State Analog of Methotrexate-Glu
(pdb code 3bi1). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Transition State Analog of Methotrexate-Glu, PDB code: 3bi1:
Jump to Zinc binding site number: 1; 2;
In total 2 binding sites of Zinc where determined in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Transition State Analog of Methotrexate-Glu, PDB code: 3bi1:
Jump to Zinc binding site number: 1; 2;
Zinc binding site 1 out of 2 in 3bi1
Go back to
Zinc Binding Sites List in 3bi1
Zinc binding site 1 out
of 2 in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Transition State Analog of Methotrexate-Glu
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Transition State Analog of Methotrexate-Glu within 5.0Å range:
|
Zinc binding site 2 out of 2 in 3bi1
Go back to
Zinc Binding Sites List in 3bi1
Zinc binding site 2 out
of 2 in the X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Transition State Analog of Methotrexate-Glu
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 2 of X-Ray Structure of Human Glutamate Carboxypeptidase II (Gcpii) in Complex with A Transition State Analog of Methotrexate-Glu within 5.0Å range:
|
Reference:
C.Barinka,
K.Hlouchova,
M.Rovenska,
P.Majer,
M.Dauter,
N.Hin,
Y.S.Ko,
T.Tsukamoto,
B.S.Slusher,
J.Konvalinka,
J.Lubkowski.
Structural Basis of Interactions Between Human Glutamate Carboxypeptidase II and Its Substrate Analogs J.Mol.Biol. V. 376 1438 2008.
ISSN: ISSN 0022-2836
PubMed: 18234225
DOI: 10.1016/J.JMB.2007.12.066
Page generated: Thu Oct 24 11:30:31 2024
ISSN: ISSN 0022-2836
PubMed: 18234225
DOI: 10.1016/J.JMB.2007.12.066
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