Zinc in PDB 2xwc: Crystal Structure of the Dna Binding Domain of Human TP73 Refined at 1.8 A Resolution

The structure of Crystal Structure of the Dna Binding Domain of Human TP73 Refined at 1.8 A Resolution, PDB code: 2xwc was solved by P.Canning, Y.Zhang, M.Vollmar, T.Krojer, E.Ugochukwu, J.R.C.Muniz, F.Vondelft, J.Weigelt, C.H.Arrowsmith, A.M.Edwards, C.Bountra, A.N.Bullock, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	49.36 / 1.82
Space group	P 43 3 2
Cell size a, b, c (Å), α, β, γ (°)	110.370, 110.370, 110.370, 90.00, 90.00, 90.00
R / Rfree (%)	18.9 / 22.8

The binding sites of Zinc atom in the Crystal Structure of the Dna Binding Domain of Human TP73 Refined at 1.8 A Resolution (pdb code 2xwc). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Crystal Structure of the Dna Binding Domain of Human TP73 Refined at 1.8 A Resolution, PDB code: 2xwc:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in the Crystal Structure of the Dna Binding Domain of Human TP73 Refined at 1.8 A Resolution


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Crystal Structure of the Dna Binding Domain of Human TP73 Refined at 1.8 A Resolution within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1319 b:20.7 occ:1.00 ND1 A:HIS197 1.8 16.7 1.0 SG A:CYS258 2.3 21.0 1.0 SG A:CYS194 2.4 19.3 1.0 SG A:CYS262 2.4 21.9 1.0 CE1 A:HIS197 2.7 25.3 1.0 CG A:HIS197 2.9 18.3 1.0 CB A:CYS262 3.1 24.4 1.0 CB A:CYS258 3.2 20.2 1.0 CB A:HIS197 3.4 16.7 1.0 CB A:CYS194 3.4 19.1 1.0 CA A:CYS258 3.8 17.1 1.0 NE2 A:HIS197 3.9 19.1 1.0 CD2 A:HIS197 4.0 23.8 1.0 N A:CYS194 4.0 20.0 1.0 CA A:CYS194 4.3 17.5 1.0 N A:HIS197 4.4 17.2 1.0 CA A:CYS262 4.5 28.6 1.0 CA A:HIS197 4.5 18.6 1.0 N A:ASN259 4.5 19.1 1.0 O A:HOH2147 4.5 25.1 1.0 O A:MET257 4.6 16.1 1.0 C A:CYS258 4.7 18.3 1.0 O A:CYS194 4.7 15.8 1.0 C A:CYS194 4.9 16.1 1.0 N A:CYS258 4.9 15.2 1.0

Zinc binding site 2 out of 2 in the Crystal Structure of the Dna Binding Domain of Human TP73 Refined at 1.8 A Resolution


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Crystal Structure of the Dna Binding Domain of Human TP73 Refined at 1.8 A Resolution within 5.0Å range: probe atom residue distance (Å) B Occ A:Zn1320 b:22.4 occ:1.00 OD1 A:ASP301 2.0 24.0 1.0 SG A:CYS297 2.3 27.1 1.0 SG A:CYS295 2.3 24.0 1.0 CG A:ASP301 2.8 23.2 1.0 OD2 A:ASP301 3.1 23.1 1.0 O A:CYS297 3.2 24.7 1.0 CB A:CYS295 3.2 24.7 1.0 C A:CYS297 3.5 24.9 1.0 CB A:CYS297 3.5 27.2 1.0 N A:CYS297 3.7 25.9 1.0 CA A:CYS297 3.7 26.1 1.0 O A:HOH2165 4.0 24.4 1.0 CB A:ASP301 4.1 22.7 1.0 N A:PRO298 4.4 24.2 1.0 O A:HOH2163 4.5 32.9 1.0 CA A:CYS295 4.6 24.8 1.0 N A:ASP301 4.6 23.9 1.0 N A:ALA296 4.6 26.2 1.0 O A:HOH2161 4.7 31.6 1.0 C A:CYS295 4.8 25.1 1.0 CA A:ASP301 4.8 23.1 1.0 C A:ALA296 4.8 27.0 1.0 CA A:PRO298 4.9 23.5 1.0

P.Canning, F.Von Delft, A.N.Bullock. Structural Basis For ASPP2 Recognition By the Tumor Suppressor P73. J.Mol.Biol. V. 423 515 2012.
ISSN: ISSN 0022-2836
PubMed: 22917970
DOI: 10.1016/J.JMB.2012.08.005