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Zinc in PDB 2xqn: Complex of the 2ND and 3RD Lim Domains of Tes with the EVH1 Domain of Mena and the N-Terminal Domain of Actin-Like Protein ARP7A

Protein crystallography data

The structure of Complex of the 2ND and 3RD Lim Domains of Tes with the EVH1 Domain of Mena and the N-Terminal Domain of Actin-Like Protein ARP7A, PDB code: 2xqn was solved by P.P.Knowles, D.C.Briggs, J.Murray-Rust, N.Q.Mcdonald, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 25.56 / 2.62
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 37.829, 86.791, 115.266, 90.00, 90.00, 90.00
R / Rfree (%) 21.5 / 26.8

Zinc Binding Sites:

The binding sites of Zinc atom in the Complex of the 2ND and 3RD Lim Domains of Tes with the EVH1 Domain of Mena and the N-Terminal Domain of Actin-Like Protein ARP7A (pdb code 2xqn). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 5 binding sites of Zinc where determined in the Complex of the 2ND and 3RD Lim Domains of Tes with the EVH1 Domain of Mena and the N-Terminal Domain of Actin-Like Protein ARP7A, PDB code: 2xqn:
Jump to Zinc binding site number: 1; 2; 3; 4; 5;

Zinc binding site 1 out of 5 in 2xqn

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Zinc binding site 1 out of 5 in the Complex of the 2ND and 3RD Lim Domains of Tes with the EVH1 Domain of Mena and the N-Terminal Domain of Actin-Like Protein ARP7A


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Complex of the 2ND and 3RD Lim Domains of Tes with the EVH1 Domain of Mena and the N-Terminal Domain of Actin-Like Protein ARP7A within 5.0Å range:
probe atom residue distance (Å) B Occ
T:Zn1422

b:39.7
occ:1.00
ND1 T:HIS322 2.1 32.2 1.0
ND1 T:HIS325 2.2 48.3 1.0
SG T:CYS304 2.3 41.1 1.0
SG T:CYS301 2.3 41.7 1.0
CE1 T:HIS325 2.8 48.8 1.0
CE1 T:HIS322 3.0 34.0 1.0
CG T:HIS322 3.1 35.5 1.0
CB T:CYS301 3.2 42.1 1.0
CB T:CYS304 3.2 43.0 1.0
CG T:HIS325 3.4 47.9 1.0
CB T:HIS322 3.4 38.0 1.0
N T:CYS304 3.7 44.8 1.0
CB T:HIS325 3.9 45.5 1.0
N T:HIS322 4.0 38.7 1.0
CA T:CYS304 4.0 44.0 1.0
NE2 T:HIS325 4.0 49.5 1.0
NE2 T:HIS322 4.2 38.8 1.0
CD2 T:HIS322 4.2 34.3 1.0
CD2 T:HIS325 4.3 49.3 1.0
CA T:HIS322 4.3 38.3 1.0
CA T:CYS301 4.6 43.0 1.0
C T:CYS304 4.8 44.2 1.0
C T:GLY303 4.9 45.2 1.0
C T:CYS301 4.9 43.5 1.0

Zinc binding site 2 out of 5 in 2xqn

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Zinc binding site 2 out of 5 in the Complex of the 2ND and 3RD Lim Domains of Tes with the EVH1 Domain of Mena and the N-Terminal Domain of Actin-Like Protein ARP7A


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Complex of the 2ND and 3RD Lim Domains of Tes with the EVH1 Domain of Mena and the N-Terminal Domain of Actin-Like Protein ARP7A within 5.0Å range:
probe atom residue distance (Å) B Occ
T:Zn1423

b:45.6
occ:1.00
SG T:CYS349 2.3 46.5 1.0
SG T:CYS331 2.3 48.0 1.0
SG T:CYS328 2.3 42.5 1.0
SG T:CYS352 2.4 46.0 1.0
CB T:CYS328 3.1 42.1 1.0
CB T:CYS331 3.2 48.0 1.0
CB T:CYS352 3.4 44.7 1.0
CB T:CYS349 3.4 43.3 1.0
N T:CYS331 3.5 47.4 1.0
N T:CYS349 3.8 42.1 1.0
CA T:CYS331 3.9 48.0 1.0
CA T:CYS349 4.1 43.0 1.0
N T:CYS352 4.3 43.2 1.0
CA T:CYS352 4.4 44.2 1.0
OG T:SER333 4.4 44.0 1.0
CB T:ASP330 4.4 46.6 1.0
C T:ASP330 4.5 47.6 1.0
CA T:CYS328 4.6 43.1 1.0
CG1 T:VAL348 4.6 43.9 1.0
C T:CYS331 4.7 48.7 1.0
N T:ASP330 4.7 47.3 1.0
CA T:ASP330 4.7 47.2 1.0
C T:CYS349 4.8 42.5 1.0
N T:ASP332 4.8 49.0 1.0
C T:VAL348 5.0 42.4 1.0

Zinc binding site 3 out of 5 in 2xqn

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Zinc binding site 3 out of 5 in the Complex of the 2ND and 3RD Lim Domains of Tes with the EVH1 Domain of Mena and the N-Terminal Domain of Actin-Like Protein ARP7A


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 3 of Complex of the 2ND and 3RD Lim Domains of Tes with the EVH1 Domain of Mena and the N-Terminal Domain of Actin-Like Protein ARP7A within 5.0Å range:
probe atom residue distance (Å) B Occ
T:Zn1424

b:37.0
occ:1.00
ND1 T:HIS383 2.1 34.2 1.0
SG T:CYS364 2.2 35.4 1.0
SG T:CYS361 2.3 33.8 1.0
SG T:CYS388 2.3 35.8 1.0
CE1 T:HIS383 3.0 35.2 1.0
CB T:CYS361 3.1 33.9 1.0
CB T:CYS364 3.2 35.1 1.0
CG T:HIS383 3.2 30.4 1.0
CB T:CYS388 3.2 35.0 1.0
N T:CYS364 3.5 36.5 1.0
CB T:HIS383 3.6 30.7 1.0
CA T:CYS364 3.9 35.6 1.0
N T:HIS383 4.0 30.6 1.0
NE2 T:HIS383 4.2 33.0 1.0
CD2 T:HIS383 4.3 31.0 1.0
CA T:HIS383 4.4 30.9 1.0
CA T:CYS388 4.5 34.7 1.0
C T:GLY363 4.6 36.9 1.0
CA T:CYS361 4.6 34.3 1.0
O T:HOH2022 4.6 30.9 1.0
C T:CYS364 4.8 35.2 1.0
CA T:GLY363 4.9 36.5 1.0
N T:GLY363 4.9 36.8 1.0
N T:HIS365 5.0 34.7 1.0

Zinc binding site 4 out of 5 in 2xqn

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Zinc binding site 4 out of 5 in the Complex of the 2ND and 3RD Lim Domains of Tes with the EVH1 Domain of Mena and the N-Terminal Domain of Actin-Like Protein ARP7A


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 4 of Complex of the 2ND and 3RD Lim Domains of Tes with the EVH1 Domain of Mena and the N-Terminal Domain of Actin-Like Protein ARP7A within 5.0Å range:
probe atom residue distance (Å) B Occ
T:Zn1425

b:42.1
occ:1.00
SG T:CYS394 2.3 36.7 1.0
SG T:CYS412 2.3 43.8 1.0
SG T:CYS391 2.3 38.9 1.0
SG T:CYS416 2.4 48.4 1.0
CB T:CYS391 3.3 38.6 1.0
CB T:CYS394 3.4 37.5 1.0
CB T:CYS416 3.4 50.3 1.0
CB T:CYS412 3.5 42.8 1.0
N T:CYS394 3.8 37.6 1.0
N T:CYS412 3.9 42.2 1.0
ZN T:ZN1426 4.1 48.5 1.0
CA T:CYS394 4.2 36.8 1.0
CA T:CYS412 4.3 43.3 1.0
CB T:CYS393 4.4 39.1 1.0
OG T:SER413 4.6 42.4 1.0
CA T:CYS391 4.8 37.9 1.0
C T:CYS393 4.8 38.2 1.0
CB T:LYS396 4.8 35.0 1.0
C T:CYS394 4.9 36.5 1.0
CA T:CYS416 4.9 50.7 1.0
SG T:CYS393 4.9 41.1 1.0
CA T:CYS393 4.9 39.3 1.0

Zinc binding site 5 out of 5 in 2xqn

Go back to Zinc Binding Sites List in 2xqn
Zinc binding site 5 out of 5 in the Complex of the 2ND and 3RD Lim Domains of Tes with the EVH1 Domain of Mena and the N-Terminal Domain of Actin-Like Protein ARP7A


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 5 of Complex of the 2ND and 3RD Lim Domains of Tes with the EVH1 Domain of Mena and the N-Terminal Domain of Actin-Like Protein ARP7A within 5.0Å range:
probe atom residue distance (Å) B Occ
T:Zn1426

b:48.5
occ:1.00
SG T:CYS393 2.3 41.1 1.0
SG T:CYS416 2.3 48.4 1.0
O T:HOH2027 2.9 56.3 1.0
CB T:CYS416 3.4 50.3 1.0
CB T:CYS393 3.4 39.1 1.0
CA T:CYS416 3.5 50.7 1.0
ZN T:ZN1425 4.1 42.1 1.0
N T:CYS416 4.2 51.5 1.0
CB T:CYS394 4.3 37.5 1.0
N T:CYS394 4.6 37.6 1.0
CG T:ARG419 4.6 61.2 1.0
CA T:CYS393 4.7 39.3 1.0
C T:CYS393 4.7 38.2 1.0
C T:CYS416 4.7 51.1 1.0
O T:CYS416 4.8 50.8 1.0
C T:GLU415 4.8 51.8 1.0
SG T:CYS394 5.0 36.7 1.0
CA T:CYS394 5.0 36.8 1.0

Reference:

B.Boeda, P.P.Knowles, D.C.Briggs, J.Murray-Rust, E.Soriano, B.K.Garvalov, N.Q.Mcdonald, M.Way. Molecular Recognition of the Tes LIM2-3 Domains By the Actin-Related Protein ARP7A. J. Biol. Chem. V. 286 11543 2011.
ISSN: ESSN 1083-351X
PubMed: 21278383
DOI: 10.1074/JBC.M110.171264
Page generated: Wed Dec 16 04:00:23 2020

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