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Zinc in PDB 2ws7: Semi-Synthetic Analogue of Human Insulin PROB26-Dti

Protein crystallography data

The structure of Semi-Synthetic Analogue of Human Insulin PROB26-Dti, PDB code: 2ws7 was solved by A.M.Brzozowski, J.Jiracek, L.Zakova, E.Antolikova, C.J.Watson, J.P.Turkenburg, G.G.Dodson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 57.26 / 2.59
Space group P 21 21 2
Cell size a, b, c (Å), α, β, γ (°) 62.451, 66.511, 57.297, 90.00, 90.00, 90.00
R / Rfree (%) 20.853 / 33.16

Other elements in 2ws7:

The structure of Semi-Synthetic Analogue of Human Insulin PROB26-Dti also contains other interesting chemical elements:

Chlorine (Cl) 2 atoms

Zinc Binding Sites:

The binding sites of Zinc atom in the Semi-Synthetic Analogue of Human Insulin PROB26-Dti (pdb code 2ws7). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Semi-Synthetic Analogue of Human Insulin PROB26-Dti, PDB code: 2ws7:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 2ws7

Go back to Zinc Binding Sites List in 2ws7
Zinc binding site 1 out of 2 in the Semi-Synthetic Analogue of Human Insulin PROB26-Dti


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Semi-Synthetic Analogue of Human Insulin PROB26-Dti within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Zn1020

b:18.5
occ:1.00
NE2 F:HIS10 2.0 16.3 1.0
NE2 J:HIS10 2.0 7.8 1.0
NE2 B:HIS10 2.1 13.4 1.0
CL B:CL1021 2.1 14.6 1.0
CE1 F:HIS10 2.9 16.1 1.0
CE1 J:HIS10 3.0 7.5 1.0
CD2 B:HIS10 3.0 14.1 1.0
CE1 B:HIS10 3.0 13.2 1.0
CD2 J:HIS10 3.1 7.8 1.0
CD2 F:HIS10 3.1 16.6 1.0
ND1 F:HIS10 4.1 13.1 1.0
ND1 J:HIS10 4.1 9.3 1.0
ND1 B:HIS10 4.2 12.8 1.0
CG B:HIS10 4.2 13.5 1.0
CG J:HIS10 4.2 9.6 1.0
CG F:HIS10 4.2 14.9 1.0
O J:LEU6 4.7 20.5 1.0
CB F:LEU6 4.8 18.4 1.0
O F:LEU6 4.8 19.0 1.0
CB B:LEU6 4.8 15.1 1.0
O B:LEU6 4.8 15.6 1.0
CB J:LEU6 5.0 20.2 1.0

Zinc binding site 2 out of 2 in 2ws7

Go back to Zinc Binding Sites List in 2ws7
Zinc binding site 2 out of 2 in the Semi-Synthetic Analogue of Human Insulin PROB26-Dti


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Semi-Synthetic Analogue of Human Insulin PROB26-Dti within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Zn1024

b:16.5
occ:1.00
NE2 L:HIS10 2.0 14.2 1.0
NE2 D:HIS10 2.0 14.3 1.0
NE2 H:HIS10 2.0 9.4 1.0
CL D:CL1025 2.1 11.2 1.0
CE1 L:HIS10 2.9 13.7 1.0
CE1 H:HIS10 2.9 7.9 1.0
CE1 D:HIS10 3.0 12.0 1.0
CD2 D:HIS10 3.0 13.3 1.0
CD2 L:HIS10 3.0 13.7 1.0
CD2 H:HIS10 3.1 6.9 1.0
ND1 L:HIS10 4.0 14.0 1.0
ND1 H:HIS10 4.0 8.1 1.0
ND1 D:HIS10 4.1 13.6 1.0
CG L:HIS10 4.1 12.8 1.0
CG D:HIS10 4.1 12.2 1.0
CG H:HIS10 4.2 7.8 1.0
O H:LEU6 4.7 12.4 1.0
O D:LEU6 4.8 13.4 1.0
O L:LEU6 4.8 14.3 1.0

Reference:

J.Jiracek, L.Zakova, E.Antolikova, C.J.Watson, J.P.Turkenburg, G.G.Dodson, A.M.Brzozowski. Implications For the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues. Proc.Natl.Acad.Sci.Usa V. 107 1966 2010.
ISSN: ISSN 0027-8424
PubMed: 20133841
DOI: 10.1073/PNAS.0911785107
Page generated: Thu Oct 17 05:00:56 2024

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