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Zinc in PDB 2ws6: Semi-Synthetic Analogue of Human Insulin NMETYRB26-Insulin in Hexamer Form

Protein crystallography data

The structure of Semi-Synthetic Analogue of Human Insulin NMETYRB26-Insulin in Hexamer Form, PDB code: 2ws6 was solved by A.M.Brzozowski, J.Jiracek, L.Zakova, E.Antolikova, C.J.Watson, J.P.Turkenburg, G.G.Dodson, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 40.00 / 1.50
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 58.962, 61.927, 47.297, 90.00, 111.90, 90.00
R / Rfree (%) 15.002 / 19.951

Zinc Binding Sites:

The binding sites of Zinc atom in the Semi-Synthetic Analogue of Human Insulin NMETYRB26-Insulin in Hexamer Form (pdb code 2ws6). This binding sites where shown within 5.0 Angstroms radius around Zinc atom.
In total 2 binding sites of Zinc where determined in the Semi-Synthetic Analogue of Human Insulin NMETYRB26-Insulin in Hexamer Form, PDB code: 2ws6:
Jump to Zinc binding site number: 1; 2;

Zinc binding site 1 out of 2 in 2ws6

Go back to Zinc Binding Sites List in 2ws6
Zinc binding site 1 out of 2 in the Semi-Synthetic Analogue of Human Insulin NMETYRB26-Insulin in Hexamer Form


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 1 of Semi-Synthetic Analogue of Human Insulin NMETYRB26-Insulin in Hexamer Form within 5.0Å range:
probe atom residue distance (Å) B Occ
J:Zn1030

b:11.0
occ:1.00
NE2 J:HIS10 2.1 9.3 1.0
NE2 B:HIS10 2.1 8.9 1.0
NE2 F:HIS10 2.1 9.6 1.0
CL J:CL1029 2.2 10.4 1.0
CE1 J:HIS10 3.0 10.6 1.0
CD2 B:HIS10 3.0 9.3 1.0
CE1 B:HIS10 3.1 11.5 1.0
CD2 J:HIS10 3.1 9.9 1.0
CE1 F:HIS10 3.1 10.4 1.0
CD2 F:HIS10 3.1 9.4 1.0
ND1 J:HIS10 4.1 12.3 1.0
ND1 B:HIS10 4.2 14.7 1.0
ND1 F:HIS10 4.2 12.1 1.0
CG B:HIS10 4.2 11.7 1.0
CG J:HIS10 4.2 8.1 1.0
CG F:HIS10 4.2 8.9 1.0
O F:LEU6 4.7 13.2 1.0
CB F:LEU6 4.8 11.5 1.0
CB J:LEU6 4.9 13.1 1.0
O B:HOH2014 4.9 30.7 1.0
O B:LEU6 5.0 11.3 1.0

Zinc binding site 2 out of 2 in 2ws6

Go back to Zinc Binding Sites List in 2ws6
Zinc binding site 2 out of 2 in the Semi-Synthetic Analogue of Human Insulin NMETYRB26-Insulin in Hexamer Form


Mono view


Stereo pair view

A full contact list of Zinc with other atoms in the Zn binding site number 2 of Semi-Synthetic Analogue of Human Insulin NMETYRB26-Insulin in Hexamer Form within 5.0Å range:
probe atom residue distance (Å) B Occ
L:Zn1029

b:10.5
occ:1.00
NE2 D:HIS10 2.0 9.8 1.0
NE2 H:HIS10 2.1 9.3 1.0
NE2 L:HIS10 2.1 8.5 1.0
CL L:CL1028 2.2 11.6 1.0
CE1 D:HIS10 3.0 10.7 1.0
CD2 D:HIS10 3.0 9.2 1.0
CE1 H:HIS10 3.0 15.5 1.0
CD2 L:HIS10 3.0 8.3 1.0
CD2 H:HIS10 3.1 8.4 1.0
CE1 L:HIS10 3.1 9.1 1.0
ND1 D:HIS10 4.1 11.0 1.0
CG D:HIS10 4.1 9.2 1.0
ND1 H:HIS10 4.1 18.3 1.0
CG L:HIS10 4.2 8.4 1.0
ND1 L:HIS10 4.2 10.5 1.0
CG H:HIS10 4.2 10.9 1.0
O D:LEU6 4.7 10.3 1.0
CB H:LEU6 4.8 10.5 1.0
O H:LEU6 4.8 13.1 1.0
CB D:LEU6 4.9 10.7 1.0

Reference:

J.Jiracek, L.Zakova, E.Antolikova, C.J.Watson, J.P.Turkenburg, G.G.Dodson, A.M.Brzozowski. Implications For the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues. Proc.Natl.Acad.Sci.Usa V. 107 1966 2010.
ISSN: ISSN 0027-8424
PubMed: 20133841
DOI: 10.1073/PNAS.0911785107
Page generated: Sat Sep 26 04:26:33 2020
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