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Zinc in PDB 2pow: The Crystal Structure of the Human Carbonic Anhydrase II in Complex with 4-Amino-6-Trifluoromethyl-Benzene-1,3- Disulfonamide
Enzymatic activity of The Crystal Structure of the Human Carbonic Anhydrase II in Complex with 4-Amino-6-Trifluoromethyl-Benzene-1,3- Disulfonamide
All present enzymatic activity of The Crystal Structure of the Human Carbonic Anhydrase II in Complex with 4-Amino-6-Trifluoromethyl-Benzene-1,3- Disulfonamide:
4.2.1.1;
4.2.1.1;
Protein crystallography data
The structure of The Crystal Structure of the Human Carbonic Anhydrase II in Complex with 4-Amino-6-Trifluoromethyl-Benzene-1,3- Disulfonamide, PDB code: 2pow
was solved by
V.Alterio,
G.De Simone,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 20.00 / 1.75 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 41.980, 41.400, 72.030, 90.00, 104.23, 90.00 |
| R / Rfree (%) | 18.4 / 21.2 |
Other elements in 2pow:
The structure of The Crystal Structure of the Human Carbonic Anhydrase II in Complex with 4-Amino-6-Trifluoromethyl-Benzene-1,3- Disulfonamide also contains other interesting chemical elements:
| Fluorine | (F) | 3 atoms |
Zinc Binding Sites:
The binding sites of Zinc atom in the The Crystal Structure of the Human Carbonic Anhydrase II in Complex with 4-Amino-6-Trifluoromethyl-Benzene-1,3- Disulfonamide
(pdb code 2pow). This binding sites where shown within
5.0 Angstroms radius around Zinc atom.
In total only one binding site of Zinc was determined in the The Crystal Structure of the Human Carbonic Anhydrase II in Complex with 4-Amino-6-Trifluoromethyl-Benzene-1,3- Disulfonamide, PDB code: 2pow:
In total only one binding site of Zinc was determined in the The Crystal Structure of the Human Carbonic Anhydrase II in Complex with 4-Amino-6-Trifluoromethyl-Benzene-1,3- Disulfonamide, PDB code: 2pow:
Zinc binding site 1 out of 1 in 2pow
Go back to
Zinc Binding Sites List in 2pow
Zinc binding site 1 out
of 1 in the The Crystal Structure of the Human Carbonic Anhydrase II in Complex with 4-Amino-6-Trifluoromethyl-Benzene-1,3- Disulfonamide
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Zinc with other atoms in the Zn binding
site number 1 of The Crystal Structure of the Human Carbonic Anhydrase II in Complex with 4-Amino-6-Trifluoromethyl-Benzene-1,3- Disulfonamide within 5.0Å range:
|
Reference:
V.Alterio,
G.De Simone,
S.M.Monti,
A.Scozzafava,
C.T.Supuran.
Carbonic Anhydrase Inhibitors: Inhibition of Human, Bacterial, and Archaeal Isozymes with Benzene-1,3-Disulfonamides-Solution and Crystallographic Studies. Bioorg.Med.Chem.Lett. V. 17 4201 2007.
ISSN: ISSN 0960-894X
PubMed: 17540563
DOI: 10.1016/J.BMCL.2007.05.045
Page generated: Thu Oct 17 03:09:37 2024
ISSN: ISSN 0960-894X
PubMed: 17540563
DOI: 10.1016/J.BMCL.2007.05.045
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